Induction of transcription through the scs insulator leads to abnormal development of Drosophila melanogaster
- Авторлар: Kyrchanova O.1, Leman D.1, Toshchakov S.1, Utkina M.1, Tikhonov M.1, Parshikov A.1, Maksimenko O.1, Georgiev P.1
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Мекемелер:
- Institute of Gene Biology
- Шығарылым: Том 52, № 10 (2016)
- Беттер: 1007-1014
- Бөлім: Molecular Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/187910
- DOI: https://doi.org/10.1134/S1022795416100057
- ID: 187910
Дәйексөз келтіру
Аннотация
A regulatory element named scs is one of the first insulators discovered in Drosophila, which was found on the boundary of the hsp70 domain. The 993-bp scs insulator contains two promoters at the ends and two polyadenylation signals located in the same orientation in the central part of the insulator. In the Drosophila transgenic lines, induction of a strong transcription through the scs insulator only in the direction that coincides with the direction of the two polyadenylation sites activity results in multiple phenotypic defects of the Drosophila development and embryonic lethality. A similar effect was not observed upon testing of other known Drosophila insulators.
Негізгі сөздер
Авторлар туралы
O. Kyrchanova
Institute of Gene Biology
Хат алмасуға жауапты Автор.
Email: olgina73@gmail.com
Ресей, Moscow, 119334
D. Leman
Institute of Gene Biology
Email: olgina73@gmail.com
Ресей, Moscow, 119334
S. Toshchakov
Institute of Gene Biology
Email: olgina73@gmail.com
Ресей, Moscow, 119334
M. Utkina
Institute of Gene Biology
Email: olgina73@gmail.com
Ресей, Moscow, 119334
M. Tikhonov
Institute of Gene Biology
Email: olgina73@gmail.com
Ресей, Moscow, 119334
A. Parshikov
Institute of Gene Biology
Email: olgina73@gmail.com
Ресей, Moscow, 119334
O. Maksimenko
Institute of Gene Biology
Email: olgina73@gmail.com
Ресей, Moscow, 119334
P. Georgiev
Institute of Gene Biology
Email: olgina73@gmail.com
Ресей, Moscow, 119334