Enviar artigo por via de e-mail Association of C3435T (rs1045642) Polymorphism of the MDR1 Gene with the Increased Risk of Colorectal Cancer in Russian Females from Central Russia
- Autores: Moskalev A.S.1,2, Barysheva E.M.3, Soldatov V.O.3,4, Frolova O.G.5, Bobyntseva O.V.1,3, Samgina T.A.6, Churnosov M.I.7, Ivanov V.P.3, Polonikov A.V.1,3, Bushueva O.Y.1,3
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Afiliações:
- Research Institute of Genetic and Molecular Epidemiology, Kursk State Medical University
- Kursk Regional Clinical Oncology Dispensary
- Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University
- Department of Pharmacology and Clinical Pharmacology, Belgorod National Research University
- Department of Oncology, Kursk State Medical University
- Department of Surgical Diseases No. 2, Kursk State Medical University
- Department of Biomedical Disciplines, Belgorod National Research University
- Edição: Volume 55, Nº 12 (2019)
- Páginas: 1514-1519
- Seção: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/189836
- DOI: https://doi.org/10.1134/S1022795419120093
- ID: 189836
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Resumo
The objective of this study was to examine associations of single nucleotide polymorphisms, rs1045642 within the MDR1 gene and rs1799930 within the NAT2 gene, with the risk of colorectal cancer (CRC) in the population of Central Russia. DNA specimens were obtained from 178 patients with CRC (87 males and 91 females) and 327 age-matched healthy controls (179 males and 148 females). Genotyping was performed using real-time PCR. Association of the studied SNPs with the risk of CRC was evaluated using logistic regression analysis. It was demonstrated that MDR1 rs1045642 polymorphism was associated with the increased risk of CRC after correction for gender, age, and smoking (OR = 1.41, 95% CI = 1.09–1.83; P = 0.008). A gender-stratified analysis showed that MDR1 rs1045642 was associated with the increased risk of CRC only in females (OR = 1.62, 95% CI = 1.11–2.35; P = 0.01). In males, no association between MDR1 rs1045642 and CRC was found. Association between MDR1 rs1045642 and the increased risk of colorectal cancer in Russian females from Central Russia was revealed.
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Sobre autores
A. Moskalev
Research Institute of Genetic and Molecular Epidemiology, Kursk State Medical University; Kursk Regional Clinical Oncology Dispensary
Email: olga.bushueva@inbox.ru
Rússia, Kursk, 305004; farmstead of Kislino, Kursk oblast, 305524
E. Barysheva
Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University
Email: olga.bushueva@inbox.ru
Rússia, Kursk, 305004
V. Soldatov
Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University; Department of Pharmacology and Clinical Pharmacology, Belgorod National Research University
Email: olga.bushueva@inbox.ru
Rússia, Kursk, 305004; Belgorod, 308015
O. Frolova
Department of Oncology, Kursk State Medical University
Email: olga.bushueva@inbox.ru
Rússia, Kursk, 305004
O. Bobyntseva
Research Institute of Genetic and Molecular Epidemiology, Kursk State Medical University; Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University
Email: olga.bushueva@inbox.ru
Rússia, Kursk, 305004; Kursk, 305004
T. Samgina
Department of Surgical Diseases No. 2, Kursk State Medical University
Email: olga.bushueva@inbox.ru
Rússia, Kursk, 305004
M. Churnosov
Department of Biomedical Disciplines, Belgorod National Research University
Email: olga.bushueva@inbox.ru
Rússia, Belgorod, 308015
V. Ivanov
Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University
Email: olga.bushueva@inbox.ru
Rússia, Kursk, 305004
A. Polonikov
Research Institute of Genetic and Molecular Epidemiology, Kursk State Medical University; Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University
Email: olga.bushueva@inbox.ru
Rússia, Kursk, 305004; Kursk, 305004
O. Bushueva
Research Institute of Genetic and Molecular Epidemiology, Kursk State Medical University; Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University
Autor responsável pela correspondência
Email: olga.bushueva@inbox.ru
Rússia, Kursk, 305004; Kursk, 305004
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