Assessment of Effects of the OPRD1 and OPRM1 Genes Encoding Opioid Receptors on Apathy in Schizophrenia
- Authors: Alfimova M.V.1, Korovaitseva G.I.1, Kondratyev N.V.1, Smirnova S.V.1, Lezheiko T.V.1, Golimbet V.E.1
-
Affiliations:
- Mental Health Research Center
- Issue: Vol 55, No 7 (2019)
- Pages: 914-917
- Section: Short Communications
- URL: https://journals.rcsi.science/1022-7954/article/view/189469
- DOI: https://doi.org/10.1134/S1022795419070020
- ID: 189469
Cite item
Abstract
Because of the involvement in motivational processes, opioid receptors are potential targets for apathy treatment in schizophrenia. We therefore searched for associations between the opioid receptor gene polymorphisms (OPRM1 (rs1799971) and OPRD1 (rs1042114, rs533123)) and apathy measured with the Apathy Evaluation Scale-S in a group of 284 schizophrenia patients. We analyzed individual genotypes, haplotypes, and the digenic interaction and observed nominally significant associations of rs1042114 genotypes and the rs1042114*rs1799971 interaction with behavioral apathy scores. The associations, however, did not withstand correction for multiple comparisons. Thus, the results did not provide enough evidence for the opioid receptor gene effects on apathy in schizophrenia patients.
Keywords
About the authors
M. V. Alfimova
Mental Health Research Center
Author for correspondence.
Email: m.alfimova@gmail.com
Russian Federation, Moscow, 115522
G. I. Korovaitseva
Mental Health Research Center
Email: m.alfimova@gmail.com
Russian Federation, Moscow, 115522
N. V. Kondratyev
Mental Health Research Center
Email: m.alfimova@gmail.com
Russian Federation, Moscow, 115522
S. V. Smirnova
Mental Health Research Center
Email: m.alfimova@gmail.com
Russian Federation, Moscow, 115522
T. V. Lezheiko
Mental Health Research Center
Email: m.alfimova@gmail.com
Russian Federation, Moscow, 115522
V. E. Golimbet
Mental Health Research Center
Email: m.alfimova@gmail.com
Russian Federation, Moscow, 115522