Suppressive and Hypermethylated MicroRNAs in the Pathogenesis of Breast Cancer
- Authors: Loginov V.I.1,2, Filippova E.A.1, Kurevlev S.V.1, Fridman M.V.3, Burdennyy A.M.1,4, Braga E.A.1,2,4
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Affiliations:
- Institute of General Pathology and Pathophysiology
- Research Center of Medical Genetics
- Institute of General Genetics
- Emanuel Institute of Biochemical Physics
- Issue: Vol 54, No 7 (2018)
- Pages: 770-787
- Section: Reviews and Theoretical Articles
- URL: https://journals.rcsi.science/1022-7954/article/view/189048
- DOI: https://doi.org/10.1134/S1022795418070086
- ID: 189048
Cite item
Abstract
MicroRNAs (miRNAs) are involved in oncogenesis by suppression of proto-oncogenes or tumor suppressive genes. This review presents data of suppressive miRNAs role in the mechanisms of occurrence and development of malignant tumors of breast cancer as the example—that is the most widespread oncopathology in women. Targets and functions of suppressive and antimetastatic miRNAs have been illustrated, as well as for suppressive miRNAs with an oncogenic potential (such as miR-200a, miR-200c) that appears probably owing to the ability of miRNA to interact with a variety of targets depending on the cellular content. Based on the published and the authors’ own data, the role of hypermethylation of promoter regions in inhibition of expression and regulatory function of miRNA genes in breast cancer was characterized. In conclusion, the authors pointed future prospects of clinical application of suppressive miRNAs in diagnostics and treatment of breast cancer.
About the authors
V. I. Loginov
Institute of General Pathology and Pathophysiology; Research Center of Medical Genetics
Email: burdennyy@gmail.com
Russian Federation, Moscow, 125315; Moscow, 115478
E. A. Filippova
Institute of General Pathology and Pathophysiology
Email: burdennyy@gmail.com
Russian Federation, Moscow, 125315
S. V. Kurevlev
Institute of General Pathology and Pathophysiology
Email: burdennyy@gmail.com
Russian Federation, Moscow, 125315
M. V. Fridman
Institute of General Genetics
Email: burdennyy@gmail.com
Russian Federation, Moscow, 117971
A. M. Burdennyy
Institute of General Pathology and Pathophysiology; Emanuel Institute of Biochemical Physics
Author for correspondence.
Email: burdennyy@gmail.com
Russian Federation, Moscow, 125315; Moscow, 119334
E. A. Braga
Institute of General Pathology and Pathophysiology; Research Center of Medical Genetics; Emanuel Institute of Biochemical Physics
Email: burdennyy@gmail.com
Russian Federation, Moscow, 125315; Moscow, 115478; Moscow, 119334