Allelic Combinations of Immune Response Genes and Risk of Development of Myocardial Infarction
- Authors: Sadikova R.I.1, Nasibullin T.R.2, Timasheva Y.R.2, Tuktarova I.A.2, Erdman V.V.2, Shein M.I.3, Nikolaeva I.E.4, Mustafina O.E.2,5
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Affiliations:
- Bashkir Republican Clinical Hospital of War Veterans
- Institute of Biochemistry and Genetics, Ufa Scientific Center
- Bashkir State Pedagogical University
- Republic Center of Cardiology
- Department of Genetics and Fundamental Medicine
- Issue: Vol 54, No 4 (2018)
- Pages: 472-481
- Section: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/188941
- DOI: https://doi.org/10.1134/S1022795418040130
- ID: 188941
Cite item
Abstract
Myocardial infarction (MI) is a multifactorial polygenic disease. It develops because of the complex interaction between many environmental and genetic factors. In this paper, we have studied associations of MI and allele combinations of 17 polymorphic markers of immune response genes in an ethnically homogeneous group of Tatars. The material for analysis was DNA samples of patients (286 men) with onset of MI at the age of 30 to 60 years and 301 essentially healthy men of the control group. Using the APSampler algorithm, we obtained allele combinations with the increased risk of MI in which allele variants CX3CR1*M (rs3732378), VCAM1*C (rs3917010), ICAM1*E (rs5498), LTA*A (rs909253), and TNFRSF1B*M (rs1061622) occurred the most often.
About the authors
R. I. Sadikova
Bashkir Republican Clinical Hospital of War Veterans
Email: NasibullinTR@yandex.ru
Russian Federation, Ufa, 450002
T. R. Nasibullin
Institute of Biochemistry and Genetics, Ufa Scientific Center
Author for correspondence.
Email: NasibullinTR@yandex.ru
Russian Federation, Ufa, 450054
Ya. R. Timasheva
Institute of Biochemistry and Genetics, Ufa Scientific Center
Email: NasibullinTR@yandex.ru
Russian Federation, Ufa, 450054
I. A. Tuktarova
Institute of Biochemistry and Genetics, Ufa Scientific Center
Email: NasibullinTR@yandex.ru
Russian Federation, Ufa, 450054
V. V. Erdman
Institute of Biochemistry and Genetics, Ufa Scientific Center
Email: NasibullinTR@yandex.ru
Russian Federation, Ufa, 450054
M. Iu. Shein
Bashkir State Pedagogical University
Email: NasibullinTR@yandex.ru
Russian Federation, Ufa, 450000
I. E. Nikolaeva
Republic Center of Cardiology
Email: NasibullinTR@yandex.ru
Russian Federation, Ufa, 450106
O. E. Mustafina
Institute of Biochemistry and Genetics, Ufa Scientific Center; Department of Genetics and Fundamental Medicine
Email: NasibullinTR@yandex.ru
Russian Federation, Ufa, 450054; Ufa, 450000