The increase in aneuploidy of embryos Is associated with pathological morphology of the sperm
- Authors: Kiseleva Y.Y.1,2, Azova M.M.2, Kodyleva T.A.1, Kirillova A.O.1,3, Ekimov A.N.1, Rakitko A.S.3, Mishieva N.G.1, Abubakirov A.N.1
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Affiliations:
- Kulakov Research Center for Obstetrics, Gynecology, and Perinatology
- Department of Biology and Genetics
- Department of Embryology
- Issue: Vol 53, No 12 (2017)
- Pages: 1378-1381
- Section: Short Communications
- URL: https://journals.rcsi.science/1022-7954/article/view/188579
- DOI: https://doi.org/10.1134/S1022795417120055
- ID: 188579
Cite item
Abstract
Chromosomes of embryos of couples with reduced number of morphologically normal sperm cells (less than 4%) and couples with a normal level of morphologically normal sperm cells (over 4%) has revealed significant differences. In the group with a low level of normal spermatozoa, the frequency of embryos with normal chromosomes is significantly reduced and incidence of sex chromosome trisomies and autosomal monosomies and trisomies is increased; a tendency to decrease has been found for the frequency of male embryos. The obtained data may be useful to establish additional criteria for preimplantation genetic screening in the case of male infertility.
Keywords
About the authors
Yu. Yu. Kiseleva
Kulakov Research Center for Obstetrics, Gynecology, and Perinatology; Department of Biology and Genetics
Author for correspondence.
Email: 79164171311@yandex.ru
Russian Federation, Moscow, 117997; Moscow, 117198
M. M. Azova
Department of Biology and Genetics
Email: 79164171311@yandex.ru
Russian Federation, Moscow, 117198
T. A. Kodyleva
Kulakov Research Center for Obstetrics, Gynecology, and Perinatology
Email: 79164171311@yandex.ru
Russian Federation, Moscow, 117997
A. O. Kirillova
Kulakov Research Center for Obstetrics, Gynecology, and Perinatology; Department of Embryology
Email: 79164171311@yandex.ru
Russian Federation, Moscow, 117997; Moscow, 119991
A. N. Ekimov
Kulakov Research Center for Obstetrics, Gynecology, and Perinatology
Email: 79164171311@yandex.ru
Russian Federation, Moscow, 117997
A. S. Rakitko
Department of Embryology
Email: 79164171311@yandex.ru
Russian Federation, Moscow, 119991
N. G. Mishieva
Kulakov Research Center for Obstetrics, Gynecology, and Perinatology
Email: 79164171311@yandex.ru
Russian Federation, Moscow, 117997
A. N. Abubakirov
Kulakov Research Center for Obstetrics, Gynecology, and Perinatology
Email: 79164171311@yandex.ru
Russian Federation, Moscow, 117997