Aberrant DNA methylation in lymphocytes of children with neurodevelopmental disorders
- Authors: Naumova O.Y.1,2,3, Rychkov S.Y.1, Odintsova V.V.2,4, Kornilov S.A.2,3, Shabalina E.V.2, Antsiferova D.V.2, Zhukova O.V.1, Grigorenko E.L.2,3
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Affiliations:
- Vavilov Institute of General Genetics
- Department of Psychology
- Texas Institute for Measurements, Evaluation and Statistics
- Bakulev Scientific Center of Cardiovascular Surgery
- Issue: Vol 53, No 11 (2017)
- Pages: 1243-1258
- Section: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/188528
- DOI: https://doi.org/10.1134/S1022795417110072
- ID: 188528
Cite item
Abstract
Recent research in the field of genomics and epigenetics has provided evidence that alterations in the system of epigenetic regulation are highly involved in the molecular etiology of neurodegenerative and neuropathic disorders. However, there is a gap in knowledge on the epigenetic perturbations that may accompany the CNS impairments during the development in the prenatal period and their manifestation as a congenital encephalopathy in the early postnatal period of child development. The present study is one of the first attempts aimed at addressing this gap. Here, we present data on genome-wide profiles of DNA methylation obtained using the Illumina HumanMethylation450 microarray in peripheral blood cells in a sample of young children (up to four years of age) diagnosed with congenital encephalopathy. We provide evidence on systematic alterations in the epigenome—predominant hypermethylation of gene promoter associated CpG islands—related to the CNS impairment in children. Specifically, we found significant DNA methylation changes in genes involved in DNA-dependent transcription regulation and transcription factor binding, with a key role of the transcription factor JUN; in genes controlling cellular response to hypoxia; and in genes involved in the control of neuronal development, functioning, and death.
About the authors
O. Yu. Naumova
Vavilov Institute of General Genetics; Department of Psychology; Texas Institute for Measurements, Evaluation and Statistics
Author for correspondence.
Email: oksana.yu.naumova@gmail.com
Russian Federation, Moscow, 119991; St. Petersburg, 119034; Houston, TX77204
S. Yu. Rychkov
Vavilov Institute of General Genetics
Email: oksana.yu.naumova@gmail.com
Russian Federation, Moscow, 119991
V. V. Odintsova
Department of Psychology; Bakulev Scientific Center of Cardiovascular Surgery
Email: oksana.yu.naumova@gmail.com
Russian Federation, St. Petersburg, 119034; Moscow, 121552
S. A. Kornilov
Department of Psychology; Texas Institute for Measurements, Evaluation and Statistics
Email: oksana.yu.naumova@gmail.com
Russian Federation, St. Petersburg, 119034; Houston, TX77204
E. V. Shabalina
Department of Psychology
Email: oksana.yu.naumova@gmail.com
Russian Federation, St. Petersburg, 119034
D. V. Antsiferova
Department of Psychology
Email: oksana.yu.naumova@gmail.com
Russian Federation, St. Petersburg, 119034
O. V. Zhukova
Vavilov Institute of General Genetics
Email: oksana.yu.naumova@gmail.com
Russian Federation, Moscow, 119991
E. L. Grigorenko
Department of Psychology; Texas Institute for Measurements, Evaluation and Statistics
Email: oksana.yu.naumova@gmail.com
Russian Federation, St. Petersburg, 119034; Houston, TX77204