Modern probabilistic and statistical approaches to search for nucleotide sequence options associated with integrated diseases
- Авторы: Rytova A.I.1,2, Khlebus E.Y.1,3, Shevtsov A.E.2, Kutsenko V.A.2, Shcherbakova N.V.1, Zharikova A.A.1, Ershova A.I.1, Kiseleva A.V.1, Boytsov S.A.1, Yarovaya E.B.1,2, Meshkov A.N.1,4
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Учреждения:
- National Research Center for Preventive Medicine of the Ministry of Healthcare of the Russian Federation
- Department of Probability Theory
- Moscow Institute of Physics and Technology (State University)
- Department of Molecular and Cell Genetics
- Выпуск: Том 53, № 10 (2017)
- Страницы: 1091-1104
- Раздел: Reviews and Theoretical Articles
- URL: https://journals.rcsi.science/1022-7954/article/view/188472
- DOI: https://doi.org/10.1134/S1022795417100088
- ID: 188472
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Аннотация
Complex diseases are a major important problem for modern medicine. These diseases arise under the influence of specific environmental and clinical-demographic factors, so-called risk factors, in combination with factors of genetic heredity. The contribution of genetic factors to the development of complex diseases is on average about 50%. The cause of complex diseases can be a lot of variants of the nucleotide sequence. In addition to common variants of single nucleotide polymorphisms (SNPs), rare variants also play a role in the development of complex diseases. This review presents modern probabilistic and statistical approaches to the search for gene variants and their combinations associated with complex diseases with an emphasis on methods for finding rare and unique variants. A comparative analysis of these approaches is performed, and a number of problems requiring resolution are formulated.
Об авторах
A. Rytova
National Research Center for Preventive Medicine of the Ministry of Healthcare of the Russian Federation; Department of Probability Theory
Email: elkhlebus@gmail.com
Россия, Moscow, 101990; Moscow, 119991
E. Khlebus
National Research Center for Preventive Medicine of the Ministry of Healthcare of the Russian Federation; Moscow Institute of Physics and Technology (State University)
Автор, ответственный за переписку.
Email: elkhlebus@gmail.com
Россия, Moscow, 101990; Dolgoprudny, Moscow oblast, 141701
A. Shevtsov
Department of Probability Theory
Email: elkhlebus@gmail.com
Россия, Moscow, 119991
V. Kutsenko
Department of Probability Theory
Email: elkhlebus@gmail.com
Россия, Moscow, 119991
N. Shcherbakova
National Research Center for Preventive Medicine of the Ministry of Healthcare of the Russian Federation
Email: elkhlebus@gmail.com
Россия, Moscow, 101990
A. Zharikova
National Research Center for Preventive Medicine of the Ministry of Healthcare of the Russian Federation
Email: elkhlebus@gmail.com
Россия, Moscow, 101990
A. Ershova
National Research Center for Preventive Medicine of the Ministry of Healthcare of the Russian Federation
Email: elkhlebus@gmail.com
Россия, Moscow, 101990
A. Kiseleva
National Research Center for Preventive Medicine of the Ministry of Healthcare of the Russian Federation
Email: elkhlebus@gmail.com
Россия, Moscow, 101990
S. Boytsov
National Research Center for Preventive Medicine of the Ministry of Healthcare of the Russian Federation
Email: elkhlebus@gmail.com
Россия, Moscow, 101990
E. Yarovaya
National Research Center for Preventive Medicine of the Ministry of Healthcare of the Russian Federation; Department of Probability Theory
Email: elkhlebus@gmail.com
Россия, Moscow, 101990; Moscow, 119991
A. Meshkov
National Research Center for Preventive Medicine of the Ministry of Healthcare of the Russian Federation; Department of Molecular and Cell Genetics
Email: elkhlebus@gmail.com
Россия, Moscow, 101990; Moscow, 117997
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