Association study of genetic markers of schizophrenia and its cognitive endophenotypes
- Authors: Bocharova A.V.1, Stepanov V.A.1,2, Marusin A.V.1, Kharkov V.N.1,2, Vagaitseva K.V.1,2, Fedorenko O.Y.3, Bokhan N.A.2,3, Semke A.V.3, Ivanova S.A.3
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Affiliations:
- Research Institute of Medical Genetics
- National Research Tomsk State University
- Mental Health Research Institute
- Issue: Vol 53, No 1 (2017)
- Pages: 139-146
- Section: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/188093
- DOI: https://doi.org/10.1134/S1022795417010033
- ID: 188093
Cite item
Abstract
A replicative analysis of associations of 15 SNPs located in the regions of 11 genes (TCF4, VRK2, NOTCH4, ZNF804A, AGBL1, RELN, ZFP64P1, KCNB2, CSMD1, CPVL, NRIP1) and three intergenic regions (SLCO6A1/LINCOO491, LOC105376248/LOC105376249, SPA17/NRGN) with schizophrenia was conducted in the Russian population of the Siberian region. These SNPs were previously identified in genome-wide association studies (GWAS) of schizophrenia and cognitive abnormalities. The present study confirmed associations of KCNB2 rs2247572, CSMD1 rs2616984, and intergenic rs12807809 located in SPA17/NRGN with schizophrenia. It was established that the frequency of the CSMD1 rs2616984 G/G genotype was higher in patients compared to the control group (OR = 1.73; CI: 1.14–2.62; р = 0.0337). The frequencies of the KCNB2 rs2247572 TT genotype (OR = 0.41; CI: 0.20–0.87; р = 0.0485) and intergenic rs12807809 CT genotype located in SPA17/NRGN (OR = 0.70; CI: 0.53–0.94; р = 0.0464) were significantly decreased in patients compared to the control group.
About the authors
A. V. Bocharova
Research Institute of Medical Genetics
Author for correspondence.
Email: anna.bocharova@medgenetics.ru
Russian Federation, Tomsk, 634050
V. A. Stepanov
Research Institute of Medical Genetics; National Research Tomsk State University
Email: anna.bocharova@medgenetics.ru
Russian Federation, Tomsk, 634050; Tomsk, 634050
A. V. Marusin
Research Institute of Medical Genetics
Email: anna.bocharova@medgenetics.ru
Russian Federation, Tomsk, 634050
V. N. Kharkov
Research Institute of Medical Genetics; National Research Tomsk State University
Email: anna.bocharova@medgenetics.ru
Russian Federation, Tomsk, 634050; Tomsk, 634050
K. V. Vagaitseva
Research Institute of Medical Genetics; National Research Tomsk State University
Email: anna.bocharova@medgenetics.ru
Russian Federation, Tomsk, 634050; Tomsk, 634050
O. Yu. Fedorenko
Mental Health Research Institute
Email: anna.bocharova@medgenetics.ru
Russian Federation, Tomsk, 634014
N. A. Bokhan
National Research Tomsk State University; Mental Health Research Institute
Email: anna.bocharova@medgenetics.ru
Russian Federation, Tomsk, 634050; Tomsk, 634014
A. V. Semke
Mental Health Research Institute
Email: anna.bocharova@medgenetics.ru
Russian Federation, Tomsk, 634014
S. A. Ivanova
Mental Health Research Institute
Email: anna.bocharova@medgenetics.ru
Russian Federation, Tomsk, 634014