Association of variable rs1801282 locus of PPARG2 gene with diabetic nephropathy
- Authors: Avzaletdinova D.S.1, Sharipova L.F.1, Kochetova O.V.2, Morugova T.V.1, Erdman V.V.2, Mustafina O.E.2
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Affiliations:
- Bashkir State Medical University
- Institute of Biochemistry and Genetics, Ufa Research Center
- Issue: Vol 52, No 8 (2016)
- Pages: 877-881
- Section: Short Communications
- URL: https://journals.rcsi.science/1022-7954/article/view/187855
- DOI: https://doi.org/10.1134/S1022795416080032
- ID: 187855
Cite item
Abstract
The association of the variable rs1801282 locus of the PPARG2 gene (peroxisome proliferator-activated receptor gamma) with type 2 diabetes mellitus and its complications was analyzed in inhabitants of the Republic of Bashkortostan. The genotype frequencies of the variable rs1801282 locus of the PPARG2 gene did not significantly differ in groups of healthy persons and patients with type 2 diabetes in all three considered inheritance models (codominant, dominant, and recessive). At the same time, it was demonstrated that the risk of one of the diabetic complications, i.e., diabetic nephropathy, was associated with the variable rs1801282 locus of the PPARG2 gene. Diabetic nephropathy was more common in patients with the C/C genotype (62.7%) compared to the C/G and G/G genotypes (37.5%), P = 0.036. The G allele is protective in regard to diabetic nephropathy (OR = 0.36) in patients with type 2 diabetes mellitus.
About the authors
D. Sh. Avzaletdinova
Bashkir State Medical University
Author for correspondence.
Email: hyppocrat@mail.ru
Russian Federation, Ufa, 450000
L. F. Sharipova
Bashkir State Medical University
Email: hyppocrat@mail.ru
Russian Federation, Ufa, 450000
O. V. Kochetova
Institute of Biochemistry and Genetics, Ufa Research Center
Email: hyppocrat@mail.ru
Russian Federation, Ufa, 450054
T. V. Morugova
Bashkir State Medical University
Email: hyppocrat@mail.ru
Russian Federation, Ufa, 450000
V. V. Erdman
Institute of Biochemistry and Genetics, Ufa Research Center
Email: hyppocrat@mail.ru
Russian Federation, Ufa, 450054
O. E. Mustafina
Institute of Biochemistry and Genetics, Ufa Research Center
Email: hyppocrat@mail.ru
Russian Federation, Ufa, 450054