Genetic mechanisms of adaptive immunity emergence in vertebrates
- Authors: Shilov E.S.1, Kuprash D.V.1,2
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Affiliations:
- Department of Immunology, Faculty of Biology
- Engelhard Institute of Molecular Biology
- Issue: Vol 52, No 7 (2016)
- Pages: 664-675
- Section: Article
- URL: https://journals.rcsi.science/1022-7954/article/view/187776
- DOI: https://doi.org/10.1134/S1022795416070097
- ID: 187776
Cite item
Abstract
The adaptive immune system in vertebrates emerged in a multistep process that can be reconstructed on the basis of the data concerning the structure of immune systems of modern cartilaginous and bony fishes, as well as of cyclostomes. The most probable evolutionary scenario is likely to be as follows: the T cell receptor loci emerged on the basis of NK cell-like receptor genes; the antibody loci evolved on the basis of T cell receptor loci; the MHC locus arose on the basis of the locus responsible for innate immunity of early chordates. The ancestral MHC molecules likely participated in the transplantation immunity before they acquired the ability of antigen peptide presentation.
About the authors
E. S. Shilov
Department of Immunology, Faculty of Biology
Author for correspondence.
Email: shilov_evgeny@inbox.ru
Russian Federation, Moscow, 119234
D. V. Kuprash
Department of Immunology, Faculty of Biology; Engelhard Institute of Molecular Biology
Email: shilov_evgeny@inbox.ru
Russian Federation, Moscow, 119234; Moscow, 119991