Synthesis and biological activities of novel pyridazine derivatives

Abstract

A series of pyridazine derivatives was synthesized and some of them showed a growth stimulatory activity during preliminary screening. Their effects on germination, morphogenesis, peroxidase activity and lignan content were tested on common bean (Phaseolus vulgaris L.) plants. 2-[4-(6-ethoxy-pyridazin-3-ylsulfanyl)-6-ethylamino-[1,3,5]triazin-2-ylsulfanyl]-acetamide (C8) accelerated flowering and fruit production. In these plants, total lignan amount in the leaves correlated with the corresponding peroxidase activities. This compound can be recommended against the lodging of crops. Like IAA, 2-(6-ethoxy-pyridazin-3-yl)-isothiourea hydrochloride (C3) stimulated adventitious root growth with necrotic transformation of the bottom stem node. It promoted growth of leaves, the early reproductive development and pod formation. Preparations C3 and C8 can be recommended for the shortening of the juvenile time. In plants treated with each of these compounds, the highest content of lignans was recorded possibly relating to type I “non-host”—like plants resistance. 2-(6-chloro-pyridazin-3-yl)-isothiourea hydrochloride (C2) exerted a stimulatory effect on the growth of vegetative organs.