Methodology of the search for and creation of original drugs
- Авторы: Seredenin S.1
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Учреждения:
- Zakusov Research Institute of Pharmacology
- Выпуск: Том 86, № 3 (2016)
- Страницы: 147-150
- Раздел: Scientific Session of the General Meeting of the Russian Academy of Sciences
- URL: https://journals.rcsi.science/1019-3316/article/view/178683
- DOI: https://doi.org/10.1134/S1019331616030072
- ID: 178683
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Аннотация
Original drugs are those that differ in the structure, mechanism, and formulation and that have proved advantages over the existing preparations. The main goal of creating original drugs is to improve the efficacy of pharmacotherapy. The author describes drug exploratory research and development methods: the principle of similarity to physiologically active substances, the design of structures that affect selected targets (receptors, ion channels, enzymes, chaperones, expression factors, etc.), and the study of the dependence of pharmacological effects on the chemical structure, as well as the content of three stages of original drug development, drawing specific examples of creating new drugs.
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Об авторах
S. Seredenin
Zakusov Research Institute of Pharmacology
Автор, ответственный за переписку.
Email: seredeninpharm@mail.ru
Россия, Moscow