The pharmacological strategy of regenerative medicine

Abstract

A rational approach to addressing the problems of regenerative medicine is pharmacological control over the functioning of endogenous stem cells by imitating natural regulatory systems of their functioning in the organism. The analysis of data obtained on various models of pathological processes showed that the activation of bone marrow stem cells, observable in the majority of cases, turned out to be insufficient to compensate for the existing damage. Despite the fact that granulocyte colony-stimulating factor and some other pharmacological agents are characterized by an independent specific activity relative to progenitor cells of various classes, the most significant therapeutic effects reached by activating cell turnover can be achieved under their concomitant use with immobilized hyaluronidase.