Vector nanosystems for drug delivery to target cells

Abstract

Traditional approaches to chemotherapy remain ineffective in the case of aggressive tumors of the central nervous system. In this context, new strategies of the targeted delivery of antitumor preparations are actively being studied. This work presents the research results for vector nanocontainer systems based on anti-Cx43 and anti-GFAP monoclonal antibodies for the therapy of experimental C6 glioma. The focus has been on the creation of a C6 glioma model in rats, the synthesis of vector immunoliposome preparations, and the study of the binding of C6 glioma cells with monoclonal anti-Cx43 and anti-GFAP antibodies in vivo after intravenous infusion. Studies using the immunofluorescence method and intravital MRI have demonstrated the possibility to visualize the periglioma space with the obtained nanocontainer systems, which makes it possible to employ such systems for the targeted delivery of diagnostic and therapeutic agents to the periglioma zone of high-grade gliomas.