Changes of Nitric Oxide Content in the Rat Hippocampus, Heart and Liver in Acute Phase of Ischemia
- Autores: Andrianov V.1,2, Pashkevich S.3, Yafarova G.1,2, Denisov A.3, Iyudin V.1, Bogodvid T.2,4, Dosina M.3, Kulchitsky V.3, Gainutdinov K.1,2
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Afiliações:
- Zavoisky Physical Technical Institute of the Russian Academy of Sciences
- Kazan Federal University
- Institute of Physiology of National Academy of Sciences of Belarus
- Volga Region State Academy of Physical Culture, Sport and Tourism
- Edição: Volume 47, Nº 9 (2016)
- Páginas: 965-976
- Seção: Article
- URL: https://journals.rcsi.science/0937-9347/article/view/247540
- DOI: https://doi.org/10.1007/s00723-016-0815-3
- ID: 247540
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Resumo
Electron paramagnetic resonance (EPR) was used as a method to record nitric oxide (NO) production in the tissues of the brain, heart and liver of healthy rats, and rats after modeling of ischemic stroke. Direct measurement of the dynamics of NO production by EPR spectroscopy in our experiments showed that after the emergence of signs of ischemic stroke, 5 h after the start of ischemia, the content of NO in the hippocampus decreased two- to threefold and this decrease was maintained at 24 and 72 h. Deserving special attention is the data demonstrating that there is a greater decrease of NO production in the tissues of the heart and liver than in the brain. Consequently, the change in intensity of NO production in the modeling of ischemic events in the brain has a systemic, not a local character.
Sobre autores
V. Andrianov
Zavoisky Physical Technical Institute of the Russian Academy of Sciences; Kazan Federal University
Email: kh_gainutdinov@mail.ru
Rússia, Sibirsky Tract, 10/7, Kazan-29, 420029; Kazan
S. Pashkevich
Institute of Physiology of National Academy of Sciences of Belarus
Email: kh_gainutdinov@mail.ru
Belarus, Minsk
G. Yafarova
Zavoisky Physical Technical Institute of the Russian Academy of Sciences; Kazan Federal University
Email: kh_gainutdinov@mail.ru
Rússia, Sibirsky Tract, 10/7, Kazan-29, 420029; Kazan
A. Denisov
Institute of Physiology of National Academy of Sciences of Belarus
Email: kh_gainutdinov@mail.ru
Belarus, Minsk
V. Iyudin
Zavoisky Physical Technical Institute of the Russian Academy of Sciences
Email: kh_gainutdinov@mail.ru
Rússia, Sibirsky Tract, 10/7, Kazan-29, 420029
T. Bogodvid
Kazan Federal University; Volga Region State Academy of Physical Culture, Sport and Tourism
Email: kh_gainutdinov@mail.ru
Rússia, Kazan; Kazan
M. Dosina
Institute of Physiology of National Academy of Sciences of Belarus
Email: kh_gainutdinov@mail.ru
Belarus, Minsk
V. Kulchitsky
Institute of Physiology of National Academy of Sciences of Belarus
Email: kh_gainutdinov@mail.ru
Belarus, Minsk
Kh. Gainutdinov
Zavoisky Physical Technical Institute of the Russian Academy of Sciences; Kazan Federal University
Autor responsável pela correspondência
Email: kh_gainutdinov@mail.ru
Rússia, Sibirsky Tract, 10/7, Kazan-29, 420029; Kazan