Changes of Nitric Oxide Content in the Rat Hippocampus, Heart and Liver in Acute Phase of Ischemia
- Авторлар: Andrianov V.1,2, Pashkevich S.3, Yafarova G.1,2, Denisov A.3, Iyudin V.1, Bogodvid T.2,4, Dosina M.3, Kulchitsky V.3, Gainutdinov K.1,2
-
Мекемелер:
- Zavoisky Physical Technical Institute of the Russian Academy of Sciences
- Kazan Federal University
- Institute of Physiology of National Academy of Sciences of Belarus
- Volga Region State Academy of Physical Culture, Sport and Tourism
- Шығарылым: Том 47, № 9 (2016)
- Беттер: 965-976
- Бөлім: Article
- URL: https://journals.rcsi.science/0937-9347/article/view/247540
- DOI: https://doi.org/10.1007/s00723-016-0815-3
- ID: 247540
Дәйексөз келтіру
Аннотация
Electron paramagnetic resonance (EPR) was used as a method to record nitric oxide (NO) production in the tissues of the brain, heart and liver of healthy rats, and rats after modeling of ischemic stroke. Direct measurement of the dynamics of NO production by EPR spectroscopy in our experiments showed that after the emergence of signs of ischemic stroke, 5 h after the start of ischemia, the content of NO in the hippocampus decreased two- to threefold and this decrease was maintained at 24 and 72 h. Deserving special attention is the data demonstrating that there is a greater decrease of NO production in the tissues of the heart and liver than in the brain. Consequently, the change in intensity of NO production in the modeling of ischemic events in the brain has a systemic, not a local character.
Авторлар туралы
V. Andrianov
Zavoisky Physical Technical Institute of the Russian Academy of Sciences; Kazan Federal University
Email: kh_gainutdinov@mail.ru
Ресей, Sibirsky Tract, 10/7, Kazan-29, 420029; Kazan
S. Pashkevich
Institute of Physiology of National Academy of Sciences of Belarus
Email: kh_gainutdinov@mail.ru
Белоруссия, Minsk
G. Yafarova
Zavoisky Physical Technical Institute of the Russian Academy of Sciences; Kazan Federal University
Email: kh_gainutdinov@mail.ru
Ресей, Sibirsky Tract, 10/7, Kazan-29, 420029; Kazan
A. Denisov
Institute of Physiology of National Academy of Sciences of Belarus
Email: kh_gainutdinov@mail.ru
Белоруссия, Minsk
V. Iyudin
Zavoisky Physical Technical Institute of the Russian Academy of Sciences
Email: kh_gainutdinov@mail.ru
Ресей, Sibirsky Tract, 10/7, Kazan-29, 420029
T. Bogodvid
Kazan Federal University; Volga Region State Academy of Physical Culture, Sport and Tourism
Email: kh_gainutdinov@mail.ru
Ресей, Kazan; Kazan
M. Dosina
Institute of Physiology of National Academy of Sciences of Belarus
Email: kh_gainutdinov@mail.ru
Белоруссия, Minsk
V. Kulchitsky
Institute of Physiology of National Academy of Sciences of Belarus
Email: kh_gainutdinov@mail.ru
Белоруссия, Minsk
Kh. Gainutdinov
Zavoisky Physical Technical Institute of the Russian Academy of Sciences; Kazan Federal University
Хат алмасуға жауапты Автор.
Email: kh_gainutdinov@mail.ru
Ресей, Sibirsky Tract, 10/7, Kazan-29, 420029; Kazan