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Vol 48, No 9 (2017)

Original Paper

An Optimized Passive Shimming Method for Bi-planar Permanent MRI Magnets

He Z., He W., Guo J.

Abstract

An optimized passive shimming method with iron shims is presented in this paper. First, the influence value of a single iron or magnetized shim is fast calculated and determined by analytic solution with a single practical measurement. Then, the correlation between the influence value and parameters of a single shim is analyzed, and the proper parameters, including the position, polarity, and size (radius and thickness), of the shimming pieces are well selected. Finally, the numbers and locations of the passive shims are optimized by mixed-integer linear programming method based on a modified central magnetic field. The optimized method is applied to a 0.5 T Bi-planar permanent magnet magnetic resonance imaging system, and the presented results prove the efficacy of this optimized passive shimming methodology.

Applied Magnetic Resonance. 2017;48(9):871-887
pages 871-887 views

Resonance Frequency and NMR Relaxation Times in Two Inequivalent 133Cs in Cs2CuBr4 and Cs2ZnBr4 Single Crystals

Lim A.R.

Abstract

The resonance frequencies and relaxation mechanisms of Cs2CuBr4 and Cs2ZnBr4 were examined by static nuclear magnetic resonance (NMR) method. Here, the two inequivalent Cs(1) and Cs(2) sites surrounded by Br ions were distinguished. The saturation recovery traces for 133Cs nuclei in Cs2CuBr4 with the paramagnetic ions, and those in Cs2ZnBr4 without the paramagnetic ions were each fitted by four exponential functions. From these results, the spin–lattice relaxation times T1 in the laboratory frame of 133Cs nuclei in the two crystals were obtained, and Cs(1) surrounded by 11 bromide ions has a longer relaxation time than Cs(2) surrounded by 9 bromide ions.

Applied Magnetic Resonance. 2017;48(9):889-899
pages 889-899 views

Superconducting Fluctuations Above the Critical Temperature in Bi2Sr2Ca1−xYxCu2O8+δ as Revealed by Microwave Absorption

Gimazov I., Talanov Y., Sakhin V., Adachi T., Noji T., Koike Y.

Abstract

The superconducting fluctuations above the critical temperature in Bi2Sr2Ca1−xYxCu2O8+δ (x = 0–0.3) single crystals are studied by microwave absorption (MWA). The maximum in the MWA temperature dependence was observed close to the critical temperature. Its formation is explained by the change of the quasiparticle density of states due to superconducting fluctuations. The fluctuation area boundary is plotted on the phase diagram using the variation of the MWA temperature dependence with the hole density and is compared with the pseudogap phase behavior.

Applied Magnetic Resonance. 2017;48(9):861-870
pages 861-870 views

Structural and Metabolic Pattern Classification for Detection of Glioblastoma Recurrence and Treatment-Related Effects

Jovanovic M., Selmic M., Macura D., Lavrnic S., Gavrilovic S., Dakovic M., Radenkovic S., Soldatovic I., Stosic-Opincal T., Maksimovic R.

Abstract

Artificial neuronal network (ANN) in classification of glioblastoma multiforme (GBM) recurrence from treatment effects using advanced magnetic resonance imaging techniques was evaluated. In 56 patients with treated GBM, normalised minimal and mean apparent-diffusion coefficient (ADC) values, vessels number on susceptibility-weighted images (SWI) and Cho/Cr ratio were analysed statistically and by ANN. Significant correlation exists between normalised minimal and mean ADC values, and no correlation between ADC and Cho/Cr values. Cut-off values for tumour presence were: 1.14 for normalised minimal ADC (54% sensitivity, 71% specificity), 1.13 for normalised mean ADC (51% sensitivity, 71% specificity), 1.8 for Cho/Cr ratio (92% sensitivity, 82% specificity), grade 2 for SWI (87% sensitivity, 82% specificity). An accurate prediction of ANN to classify patients into GBM progression or treatment effects group was 99% during the training and 96.8% during the testing phase. Multi-parametric ANN allows distinction between GBM recurrence and treatment effects, and can be used in clinical practice.

Applied Magnetic Resonance. 2017;48(9):921-931
pages 921-931 views

The Morpho-Functional Characteristics of Cerebral and Renal Arteries After Induced Arterial Hypertension in Rats Using Magnetic Resonance Imaging

Agafonova I.G., Kotelnikov V.N., Geltcer B.I., Kolosova N.G., Stonik V.A.

Abstract

The morpho-functional reorganization of regional vascular arteries is greatly altered after the induction of arterial hypertension (AH) in experimental rats. These changes can be examined using magnetic resonance imaging methods. In our experiment, induced AH caused arteriostenosis of cerebral arteries in two strains of rats—Wistar and OXYS (p < 0.05). In addition, we studied the changes in renal arteries in the same experiment. Compensatory vasodilatation was found in the extrarenal part of arteries. Arteriostenosis was detected in the intrarenal part of arteries, which was due to cytotoxic hypostasis of renal parenchyma. We proposed a cerebral vascular index and applied this index for precise analysis of changes in the studied arteries. This index is calculated as the ratio of the diameter of cerebral arteries to the diameter of renal arteries. The degree of differences in vasoconstriction between cerebral and renal arteries was established. Our results showed a moderate degree of differences in the vasoconstriction of cerebral arteries. In addition, the degree of differences in the vasoconstriction of intrarenal arteries revealed deeper vasoconstriction. These distinctions are 28.1% (p < 0.05) and 60.9% (p < 0.05) for Wistar and OXYS rats, respectively. Arterial morphometry revealed reduced sizes of all OXYS rat arteries compared with those of Wistar rat arteries. These pathological changes were associated with excessive stiffness (rigidity) of vascular walls due to accelerated aging. The accelerated aging of OXYS rat arteries led to a decrease in their vasodilatation potential and a decrease in the blood supply of cerebral and renal arteries. Comparative morphometry of the status of all arteries in both groups after AH revealed multiple specific changes in the remodeled arteries.

Applied Magnetic Resonance. 2017;48(9):911-919
pages 911-919 views

13C Dynamic Nuclear Polarization Using Derivatives of TEMPO Free Radical

Niedbalski P., Parish C., Wang Q., Kiswandhi A., Lumata L.

Abstract

The nitroxide-based 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) free radical is widely used in 13C dynamic nuclear polarization (DNP) due to its relatively low cost, commercial availability, and effectiveness as polarizing agent. While a large number of TEMPO derivatives are available commercially, so far, only few have been tested for use in 13C DNP. In this study, we have tested and evaluated the 13C hyperpolarization efficiency of eight derivatives of TEMPO free radical with different side arms in the 4-position. In general, these TEMPO derivatives were found to have slight variations in efficiency as polarizing agents for DNP of 3 M [1-13C] acetate in 1:1 v/v ethanol:water at 3.35 T and 1.2 K. X-band electron paramagnetic resonance (EPR) spectroscopy revealed no significant differences in the spectral features among these TEMPO derivatives. 2H enrichment of the ethanol:water glassing matrix resulted in further improvement of the solid-state 13C DNP signals by factor of 2 to 2.5-fold with respect to the 13C DNP signal of non-deuterated DNP samples. These results suggest an interaction between the nuclear Zeeman reservoirs and the electron dipolar system via the thermal mixing mechanism.

Applied Magnetic Resonance. 2017;48(9):933-942
pages 933-942 views

Joint Reconstruction of Multi-contrast Images and Multi-channel Coil Sensitivities

Chen Z., Ren Y., Su S., Shi C., Ji J.X., Zheng H., Liu X., Xie G.

Abstract

Magnetic resonance imaging (MRI) has an important feature that it provides multiple images with different contrasts for complementary diagnostic information. However, a large amount of data is needed for multi-contrast images depiction, and thus, the scan is time-consuming. Many methods based on parallel magnetic resonance imaging (pMRI) and compressed sensing (CS) are applied to accelerate multi-contrast MR imaging. Nevertheless, the image reconstructed by sophisticated pMRI methods contains residual aliasing artifact that degrades the quality of the image when the acceleration factor is high. Other methods based on CS always suffer the regularization parameter-selecting problem. To address these issues, a new method is presented for joint multi-contrast image reconstruction and coil sensitivity estimation. The coil sensitivities can be shared during the reconstruction due to the identity of coil sensitivity profiles of different contrast images for imaging stationary tissues. The proposed method uses the coil sensitivities as sharable information during the reconstruction to improve the reconstruction quality. As a result, the residual aliasing artifact can be effectively removed in the reconstructed multi-contrast images even if the acceleration factor is high. Besides, as there is no regularization term in the proposed method, the troublesome regularization parameter selection in the CS can also be avoided. Results from multi-contrast in vivo experiments demonstrated that multi-contrast images can be jointly reconstructed by the proposed method with effective removal of the residual aliasing artifact at a high acceleration factor.

Applied Magnetic Resonance. 2017;48(9):955-969
pages 955-969 views

Comparison of 12 Quadrature Birdcage Coils with Different Leg Shapes at 9.4 T

Xu Y., Wen Q.

Abstract

The purpose of this study was to analyse the relationship between the radio frequency (RF) coil performance and conductor surface shape for ultra-high field (UHF) magnetic resonance imaging. Twelve different leg-shaped quadrature birdcage coils were modeled and built, e.g., 4 mm-width-leg conventional birdcage coil, 7 mm-width-leg conventional birdcage, 10 mm-width-leg conventional birdcage coil, 13 mm-width-leg conventional birdcage coil, inside arc-shape-leg birdcage coil, outward arc-shape-leg birdcage coil, inside right angle-shape-leg birdcage coil, outward right angle-shape-leg birdcage coil, vertical 4 mm-width-leg vertical birdcage, 6 mm-width-leg vertical birdcage, 8 mm-width-leg vertical birdcage and 10 mm-width-leg vertical birdcage. Studies were carried out in both electromagnetic simulations with finite element method as well as in vitro saline phantom experiments at 9.4 T. Both the results of simulation and experiment showed that conventional birdcage coil produces the highest signal-to-noise ratio (SNR) while the vertical birdcage coil produces the most homogeneous RF magnetic (B1) field at UHF. For conventional birdcage coils, as well as the vertical birdcage coils, only the proper width of legs results in the best performance (e.g., B1 homogeneous and SNR). For vertical birdcage coils, the wider the leg size, the higher RF magnetic (B1) field intensity distribution.

Applied Magnetic Resonance. 2017;48(9):901-909
pages 901-909 views

Original Article

The Power of EPR Techniques in Investigating Functionalization and Penetration into Fibers of Cotton-Bound Antimicrobial Peptides

Dzuba S.A., Uvarov M.N., Utkin D.E., Formaggio F., Bedon A., Orlandin A., Peggion C.

Abstract

The development of protective and safe textiles is of fundamental importance for defending the human body from bacterial infections. To this aim, garments are often functionalized with antibacterial agents. We recently started a program aimed at covalently linking antimicrobial peptides to cotton tissues. To optimize the process of binding, it is necessary to know the degree of functionalization and how deeply peptides penetrate into the cotton fiber. Here, we present a spin-label electron paramagnetic resonance (EPR) approach for obtaining data on the peptide incorporation into the fibers. The approach is based on the line broadening in conventional EPR and on the signal decays in electron spin echo spectroscopy that is a pulsed version of EPR.

Applied Magnetic Resonance. 2017;48(9):943-953
pages 943-953 views

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