Spin–Lattice Relaxation and Diffusion Processes in Aqueous Solutions of Gadolinium-Based Upconverting Nanoparticles at Different Magnetic Fields
- Authors: Kristinaityte K.1, Zalewski T.2, Kempka M.2, Sakirzanovas S.3, Baziulyte-Paulaviciene D.3, Jurga S.2, Rotomskis R.1,4, Valeviciene N.R.5
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Affiliations:
- Faculty of Physics, Vilnius University
- NanoBioMedical Center, Adam Mickiewicz University
- Faculty of Chemistry and Geosciences, Vilnius University
- Laboratory of Biomedical Physics, National Cancer Institute
- Faculty of Medicine, Vilnius University
- Issue: Vol 50, No 4 (2019)
- Pages: 553-561
- Section: Original Paper
- URL: https://journals.rcsi.science/0937-9347/article/view/248485
- DOI: https://doi.org/10.1007/s00723-018-1105-z
- ID: 248485
Cite item
Abstract
We investigated the influence of gadolinium (Gd)-based upconverting nanoparticles (UCNPs) on water spin–lattice relaxation (T1) and diffusion at different magnetic field strengths (0.4 T and 9.4 T). Our findings show that smaller NPs (12 nm compared to 19 nm) were more favourable for proton relaxivity. We also demonstrate that using simplified Solomon–Bloembergen–Morgan (SBM) model we can associate two measured diffusion coefficients with processes occurring near the surface of UCNPs and in bulk water. Using the relationship between relaxation and diffusion, we can estimate not only the total impact of NPs on relaxation of water molecules, but also the impact on relaxation of local water molecules, directly connected to paramagnetic Gd3+ ions in NPs. Different magnetic field strengths did not alter the spin–lattice relaxivity of NPs. This suggests that Gd-based UCNPs could be developed into high-performance multimodal magnetic resonance imaging contrast agents working over a broad range of imaging field strengths used in clinical routine.
About the authors
Kristina Kristinaityte
Faculty of Physics, Vilnius University
Author for correspondence.
Email: kkristinaityte@gmail.com
ORCID iD: 0000-0003-4778-4685
Lithuania, Sauletekio 9-3, Vilnius, 10222
Tomasz Zalewski
NanoBioMedical Center, Adam Mickiewicz University
Email: kkristinaityte@gmail.com
Poland, Umultowska 85, Poznan, 61-614
Marek Kempka
NanoBioMedical Center, Adam Mickiewicz University
Email: kkristinaityte@gmail.com
Poland, Umultowska 85, Poznan, 61-614
Simas Sakirzanovas
Faculty of Chemistry and Geosciences, Vilnius University
Email: kkristinaityte@gmail.com
Lithuania, Naugarduko 24, Vilnius, 10222
Dovile Baziulyte-Paulaviciene
Faculty of Chemistry and Geosciences, Vilnius University
Email: kkristinaityte@gmail.com
Lithuania, Naugarduko 24, Vilnius, 10222
Stefan Jurga
NanoBioMedical Center, Adam Mickiewicz University
Email: kkristinaityte@gmail.com
Poland, Umultowska 85, Poznan, 61-614
Ricardas Rotomskis
Faculty of Physics, Vilnius University; Laboratory of Biomedical Physics, National Cancer Institute
Email: kkristinaityte@gmail.com
Lithuania, Sauletekio 9-3, Vilnius, 10222; Vilnius
Nomeda R. Valeviciene
Faculty of Medicine, Vilnius University
Email: kkristinaityte@gmail.com
Lithuania, Santariskiu 2, Vilnius, 08661