Assessment of Combined Therapy of Histochrome and Nebivalol as Angioprotectors on the Background of Experimental Hypertension by Magnetic Resonance Angiography
- Authors: Agafonova I.G.1, Kotelnikov V.N.2, Geltser B.I.3, Kolosova N.G.4, Stonik V.A.1
-
Affiliations:
- G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branches of the Russian Academy of Sciences
- Far Eastern Branches of the State Research and Test Institute of Military Medicine of the Ministry Defense of the Russian Federation
- Far Eastern Federal University
- Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk State University
- Issue: Vol 49, No 2 (2018)
- Pages: 217-225
- Section: Original Paper
- URL: https://journals.rcsi.science/0937-9347/article/view/248005
- DOI: https://doi.org/10.1007/s00723-017-0960-3
- ID: 248005
Cite item
Abstract
The renovascular model of arterial hypertension (AH) was induced in Wistar and OXYS strains. The model of AH was verified by magnetic resonance angiography. It was shown that histochrome enhances the vasodilatory effect of selective beta1 blocker, nebivalol, against cerebral and renal arteries using a combined therapy in this model. Monotherapy with histochrome had no significant effect on blood pressure. The angioprotective effect of histochrome in the combined therapy was significantly more expressed in hypertensive OXYS rats compared to hypertensive Wistar rats as shown by magnetic resonance imaging (MRI) morphometry. These differences were more observable in the intrarenal part of renal arteries. The degree of regional discirculation of arteries was calculated by the Cerebro-Renal Vascular Index, which confirms the therapeutic advantage of combined therapy with histochrome and nebivalol in the background of AH. Thus, comparative MRI angiography and MRI morphometry of the cerebral and renal arteries in hypertensive Wistar and OXYS strain rats showed that histochrome expands the therapeutic potential of nebivalol due to angioprotective effects in the vascular region of the target organs.
About the authors
Irina G. Agafonova
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branches of the Russian Academy of Sciences
Author for correspondence.
Email: agafonova@piboc.dvo.ru
Russian Federation, Vladivostok
Vladimir N. Kotelnikov
Far Eastern Branches of the State Research and Test Institute of Military Medicine of the Ministry Defense of the Russian Federation
Email: agafonova@piboc.dvo.ru
Russian Federation, Vladivostok
Boris I. Geltser
Far Eastern Federal University
Email: agafonova@piboc.dvo.ru
Russian Federation, Vladivostok
Natalya G. Kolosova
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk State University
Email: agafonova@piboc.dvo.ru
Russian Federation, Novosibirsk
Valentin A. Stonik
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branches of the Russian Academy of Sciences
Email: agafonova@piboc.dvo.ru
Russian Federation, Vladivostok