Mimicking the Electromagnetic Distribution in the Human Brain: A Multi-frequency MRI Head Phantom


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Аннотация

The purpose of this study was to fabricate and test a multi-frequency human brain-mimicking phantom for magnetic resonance imaging (MRI) assessment purposes. An anatomically realistic human head phantom was elaborated, for different Larmor frequencies, which allows rapid quantification of \({\text{B}}_{1}^{ + }\). It is a simple alternative solution in time and cost as compared to numerical simulations to validate simulation when the coil geometry and components cannot be known as a unique solution. The permittivity \(\varepsilon^{{\prime }}\) and conductivity \(\sigma\) of sucrose/salt/agar aqueous solutions of varying concentrations were determined; a solution with these components and having the adequate concentration to obtain the brain’s dielectric properties at 3, 7 and 11.7T was manufactured. An anthropomorphic polymeric skull was filled with this mixture. To check the behavior of this phantom in a MRI configuration, both numerical and experimental validations were done: a \({\text{B}}_{1}^{ + }\) field distribution inside the phantom was calculated with CST Microwave Studio inside a birdcage coil at 7T; the same mapping was assessed in a 7T MRI. The feasibility of a multi-MRI static field phantom was demonstrated. A solution composed by 54.7 wt% of sucrose, 3.1 wt% of salt and 3.1 wt% of agar was fabricated with good permittivity and conductivity matching for 3, 7 and 11.7T. The results were confirmed by both numerical simulation and MRI acquisition. This work has shown the possibility of manufacturing a head phantom with accessible and cheap components for MRI evaluation, having an adequate \({\text{B}}_{1}^{ + }\) field distribution and the dielectric properties of the human brain.

Авторлар туралы

Ana Neves

Aix Marseille Univ, CNRS, Centrale Marseille, Institut Fresnel; Centre Commun de Ressources en Micro-ondes, IUSTI-Technopôle de Château-Gombert

Хат алмасуға жауапты Автор.
Email: Luisa.neves@fresnel.fr
ORCID iD: 0000-0003-1763-2074
Франция, Marseille; Marseille

Lisa Leroi

CEA-Saclay, DRF/I2BM/Neurospin

Email: Luisa.neves@fresnel.fr
Франция, Gif-sur-Yvette Cedex, 91191

Nicolas Cochinaire

Aix Marseille Univ, CNRS, Centrale Marseille, Institut Fresnel; Centre Commun de Ressources en Micro-ondes, IUSTI-Technopôle de Château-Gombert

Email: Luisa.neves@fresnel.fr
Франция, Marseille; Marseille

Redha Abdeddaim

Aix Marseille Univ, CNRS, Centrale Marseille, Institut Fresnel

Email: Luisa.neves@fresnel.fr
Франция, Marseille

Pierre Sabouroux

Aix Marseille Univ, CNRS, Centrale Marseille, Institut Fresnel

Email: Luisa.neves@fresnel.fr
Франция, Marseille

Alexandre Vignaud

CEA-Saclay, DRF/I2BM/Neurospin

Email: Luisa.neves@fresnel.fr
Франция, Gif-sur-Yvette Cedex, 91191

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© Springer-Verlag Wien, 2017