Email this article Glycosylated Gadolinium as Potential Metabolic Contrast Agent vs Gd-DTPA for Metabolism of Tumor Tissue in Magnetic Resonance Imaging
- Authors: Rafiei B.1, Nikfari B.2, Amirrashedi M.2, Heydarnezhadi S.2, Riahi Alam N.2, Haghgoo S.3, Ghanaati H.1, Khoobi M.4, Gorji E.3
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Affiliations:
- Medical Imaging Center, Imam Hospital Complex, School of Medicine, Tehran University of Medical Sciences (TUMS)
- Medical Physics and Biomedical Engineering Department, School of Medicine, Tehran University of Medical Sciences (TUMS)
- Pharmaceutical Department, Food and Drug Laboratory Research Center, Food and Drug Organization (FDO), Ministry of Health
- Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences
- Issue: Vol 47, No 4 (2016)
- Pages: 375-385
- Section: Article
- URL: https://journals.rcsi.science/0937-9347/article/view/247448
- DOI: https://doi.org/10.1007/s00723-015-0756-2
- ID: 247448
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Abstract
Modern imaging technologies such as mMRI employ contrast agents to visualize the tumor microenvironment; therefore, demand for contrast agents, with an enhanced sensitivity and tissue tumor-specific target, is very high. The purpose of this study synthesizes novel metabolic contrast agent (Gd-DTPA-DG) and evaluates accumulation in tumor tissue for early diagnostic cancer. The contrast agent was synthesized and characterized with using different techniques including dynamic light scattering, high resolution transmission electron microscopy, Fourier transform infrared spectroscopy and inductively coupled plasma atomic emission spectroscopy (ICP-AES). Finally, MRI imaging performed to determine in vitro and in vivo relaxometry. Gd-DTPA-DG was specifically investigated in tissue tumor over a 45 min in vivo because of its ability to target metabolically active tumor tissue, and comparison with conventional contrast agent [Gd-DTPA (Magnevist, Bayer-USA)]. According to the result, the maximum image signal intensity in different concentrations (0.02 to approximately 0.8 mM), longitudinal relaxation time (T1) and transverse relaxation time (T2) were obtained. Signal intensity of tumor tissue was shown at 15 and 30 min after injection reaches maximum for Gd-DTPA-DG and Gd-DTPA (Magnevist, Bayer-USA), respectively. But Gd-DTPA-DG shown signal intensity higher of Gd-DTPA (Magnevist, Bayer-USA) over 45 min, comparison with Gd-DTPA (Magnevist, Bayer-USA). Images showed metabolic contrast agent penetrate into cells and accumulated in tumor. These results showed that the novel metabolic contrast agent could become a useful tool in early detection of cancer.
About the authors
Behrooz Rafiei
Medical Imaging Center, Imam Hospital Complex, School of Medicine, Tehran University of Medical Sciences (TUMS)
Email: sara_h_68@yahoo.com
Iran, Islamic Republic of, Keshavaz Blvd., Tehran, 1419733141
Banafsheh Nikfari
Medical Physics and Biomedical Engineering Department, School of Medicine, Tehran University of Medical Sciences (TUMS)
Email: sara_h_68@yahoo.com
Iran, Islamic Republic of, Keshavaz blvd, 16 Azar St, Tehran, 14145
Mahsa Amirrashedi
Medical Physics and Biomedical Engineering Department, School of Medicine, Tehran University of Medical Sciences (TUMS)
Email: sara_h_68@yahoo.com
Iran, Islamic Republic of, Keshavaz blvd, 16 Azar St, Tehran, 14145
Sara Heydarnezhadi
Medical Physics and Biomedical Engineering Department, School of Medicine, Tehran University of Medical Sciences (TUMS)
Author for correspondence.
Email: sara_h_68@yahoo.com
Iran, Islamic Republic of, Keshavaz blvd, 16 Azar St, Tehran, 14145
Nader Riahi Alam
Medical Physics and Biomedical Engineering Department, School of Medicine, Tehran University of Medical Sciences (TUMS)
Email: sara_h_68@yahoo.com
Iran, Islamic Republic of, Keshavaz blvd, 16 Azar St, Tehran, 14145
Soheila Haghgoo
Pharmaceutical Department, Food and Drug Laboratory Research Center, Food and Drug Organization (FDO), Ministry of Health
Email: sara_h_68@yahoo.com
Iran, Islamic Republic of, Imam St., Valiasre Cross, Tehran, 1113615911
Hossein Ghanaati
Medical Imaging Center, Imam Hospital Complex, School of Medicine, Tehran University of Medical Sciences (TUMS)
Email: sara_h_68@yahoo.com
Iran, Islamic Republic of, Keshavaz Blvd., Tehran, 1419733141
Mehdi Khoobi
Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences
Email: sara_h_68@yahoo.com
Iran, Islamic Republic of, Tehran, 14176
Ensiyeh Gorji
Pharmaceutical Department, Food and Drug Laboratory Research Center, Food and Drug Organization (FDO), Ministry of Health
Email: sara_h_68@yahoo.com
Iran, Islamic Republic of, Imam St., Valiasre Cross, Tehran, 1113615911
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