A Look at Phage Therapy One Hundred Years After the Bacteriophages Discovery


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This overview discusses the literature data on the use of bacteriophages in the treatment of both acute and chronic infectious diseases caused by antibiotic-resistant pathogens. Traditionally, phage therapy is based on the use of naturally occurring phages for infection and lysis of bacteria at the site of infection. It has fundamental advantages over antibiotic therapy. At the same time, it has some disadvantages. Currently, the application of biotechnological methods, such as the development of the recombinant bacteriophages, makes it possible to eliminate the shortcomings of antimicrobial phage therapy and to expand its opportunities due to the use of lytic proteins of phages and their modified derivatives.

作者简介

T. Ilyina

Gamaleya National Research Center of Epidemiology and Microbiology of the Ministry of Health of the Russian Federation

Email: genes2007@yandex.ru
俄罗斯联邦, Moscow, 123098

E. Tolordava

Gamaleya National Research Center of Epidemiology and Microbiology of the Ministry of Health of the Russian Federation

Email: genes2007@yandex.ru
俄罗斯联邦, Moscow, 123098

Yu. Romanova

Gamaleya National Research Center of Epidemiology and Microbiology of the Ministry of Health of the Russian Federation; Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

编辑信件的主要联系方式.
Email: genes2007@yandex.ru
俄罗斯联邦, Moscow, 123098; Moscow, 119091

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