Comparative analysis of glucose metabolism in strains of Vibrio cholera biovar El Tor


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Comparative analysis of glucose fermentation in typical strains of V. cholerae biovar El Tor isolated in the Russian Federation in 1970–1990 and highly virulent strains of genovariants imported in 1993–2012 was carried out. It was demonstrated that glucose metabolism of V. cholerae biovar El Tor genovariants changed as a result of acquisition of classical CTX prophage (or only its ctxB gene) and a corresponding increase in virulence. A phenotypical manifestation of these changes is a lack of ability to grow on a minimal nutrient medium supplemented with 1% carbohydrate, as well as compromised capacity for acetoin fermentation in the course of the Voges–Proskauer test. Possible causes of the degraded glucose metabolism are associated with the presence of SNP in gene alsD that encodes acetolactate decarboxylase enzyme and is incorporated into als operon, which, in turn, is involved in acetoin generation, as well as with hyperexpression of regulatory protein AphA that controls acetoin biosynthesis.

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S. Zadnova

Russian Research Anti-Plague Institute Microbe

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Email: rusrapi@microbe.ru
俄罗斯联邦, Saratov, 410005

N. Cheldyshova

Russian Research Anti-Plague Institute Microbe

Email: rusrapi@microbe.ru
俄罗斯联邦, Saratov, 410005

A. Kritskii

Russian Research Anti-Plague Institute Microbe

Email: rusrapi@microbe.ru
俄罗斯联邦, Saratov, 410005

A. Adamov

Russian Research Anti-Plague Institute Microbe

Email: rusrapi@microbe.ru
俄罗斯联邦, Saratov, 410005

Z. Devdariani

Russian Research Anti-Plague Institute Microbe

Email: rusrapi@microbe.ru
俄罗斯联邦, Saratov, 410005

V. Kutyrev

Russian Research Anti-Plague Institute Microbe

Email: rusrapi@microbe.ru
俄罗斯联邦, Saratov, 410005

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