SOX9 as One of the Central Units of Regulation Axis of Pancreas Embryogenesis and Cancer Progression
- Авторы: Bulanenkova S.S.1, Snezhkov E.V.1, Akopov S.B.1
-
Учреждения:
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
- Выпуск: Том 34, № 3 (2019)
- Страницы: 159-169
- Раздел: Reviews
- URL: https://journals.rcsi.science/0891-4168/article/view/178371
- DOI: https://doi.org/10.3103/S0891416819030030
- ID: 178371
Цитировать
Аннотация
The embryonic development of all body systems is controlled by coordinated interactions of a group of genes encoding master regulators of development, which determine the fate of cells in the process of differentiation. These genes are often involved in the processes of malignant degeneration of cells. Hence, they are considered as targets of targeted gene therapy in the development of modern approaches to cancer treatment. One of the most aggressive forms of cancer is pancreatic ductal adenocarcinoma (PDAC). Thus, the study of pancreas master regulators genes is a challenging task. This review is devoted to SOX9, which is one of the key master regulators of pancreatic development and is a crucial factor in the induction and progression of PDAC.
Ключевые слова
Об авторах
S. Bulanenkova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Автор, ответственный за переписку.
Email: sun-lioness@mail.ru
Россия, Moscow, 117997
E. Snezhkov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: sun-lioness@mail.ru
Россия, Moscow, 117997
S. Akopov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: sun-lioness@mail.ru
Россия, Moscow, 117997
Дополнительные файлы
