Email this article The IGF-I/IGF-IR Signaling System and Pancreatic Cancer
- Authors: Kopantzev E.P.1, Grankina E.V.1, Kopantseva M.R.1, Sverdlov E.D.1
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Affiliations:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Issue: Vol 32, No 3 (2017)
- Pages: 131-136
- Section: Reviews
- URL: https://journals.rcsi.science/0891-4168/article/view/178201
- DOI: https://doi.org/10.3103/S0891416817030041
- ID: 178201
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Abstract
Ductal adenocarcinoma is one of the most common and severely aggressive forms of pancreatic cancer. IGF-I is one of the factors that ensures survival and proliferation of tumor cells, and its increased concentration inside the tumor is a characteristic sign of many malignant formations. The goal of this minireview is to provide an up-to-date insight on the roles of the IGF-I/IGF-IR signaling pathway in carcinogenesis and potential opportunities for pharmacologic targeting of IGF-I/IGF-IR in pancreatic tumors.
About the authors
E. P. Kopantzev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Author for correspondence.
Email: kopantzev@ibch.ru
Russian Federation, Moscow, 117997
E. V. Grankina
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: kopantzev@ibch.ru
Russian Federation, Moscow, 117997
M. R. Kopantseva
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: kopantzev@ibch.ru
Russian Federation, Moscow, 117997
E. D. Sverdlov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: kopantzev@ibch.ru
Russian Federation, Moscow, 117997
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