Features of changes in protein metabolism in patients with polytrauma depending on the timing of surgical treatment of injuries of the musculoskeletal system

The evaluation of the peculiarities of protein metabolism changes depending on the terms of surgical treatment of the loco-motor system injuries was petformed in patients with polytrauma. It was shown that plasma fibrinogen increase, posttraumatic metabolic azotemia, i.e. increase of blood urea and creatinine levels, decrease of total protein level were present in all patients. In the same time disproteinemia, i.e. decrease of albumin levels and increase of globulin fractions (more significantly alpha-1 and alpha-2 globulins) was noted. In contrast to the delayed treatment early surgical intervention was accompanied by redistribution of the fraction composition of proteins in a form of the earlier normalization of the relative quantity of alpha-1 and alpha-2 globulins. This is an evidence of the plastic exchange restoration and possibilities of compensatory responses of the organism.