The study of autoantibodies to collagen of various types in the blood serum of patients with degenerative-dystrophic diseases of the hip joints

The level of autoantibody (AAB) to collagen was studied in serum of patients with degenerative dystrophic hip joint diseases: deforming coxarthrosis of I, II, III degree, aseptic necrosis of femur head of III, TV degree and cystic remodeling of articular ends of II, III degree. In 123 patients level of AAB to general determinants of collagens was detected using reaction of passive hemagglutination. In 24% of patients high diagnostically significant of AAB titers to collagen were determined. Correlation of AAB level and general determinants of various collagen types as well as the type of articular pathology were studied. In 62 patients AAB level to collagen of I, II, III and IV types was detected using solid phase immunoenzyme analysis. High level of AAB to collagen of I, II types was shown. In patients with aseptic necrosis reliable increase of AAB level to collagen of I (osseous) type and marked tendency to the increase of AAB level to collagen of II (cartilagenous) type was detected. In patients with cystic remodeling reliable increase of AAB level to collagen of II type and tendency to the increase of AAB level to collagen of I type was observed. Strong correlation between AAB level to collagen of II type and clinical manifestations of pathology was determined.