Experimental model of hereditary spinal deformity

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Abstract

Model of spine deformity-like SheuermannMau disease was obtained by crossing of two lines of mice with known genetic defects. Results of morphologic and ultrastructural studies permitted to extra-polate the obtained data, with certain prudence, on clinical manifestations of investigated pathology and to explain the main pathogenic mechanisms of process development.

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About the authors

A. M. Zaydman

Research Institute of Traumatology and Orthopedics; Institute of Cytology and Genetics SB RAS

Email: info@eco-vector.com
Russian Federation, Novosibirsk; Novosibirsk

P. M. Borodin

Research Institute of Traumatology and Orthopedics; Institute of Cytology and Genetics SB RAS

Email: info@eco-vector.com
Russian Federation, Novosibirsk; Novosibirsk

T. V. Rusova

Research Institute of Traumatology and Orthopedics; Institute of Cytology and Genetics SB RAS

Email: info@eco-vector.com
Russian Federation, Novosibirsk; Novosibirsk

A. V. Korel

Research Institute of Traumatology and Orthopedics; Institute of Cytology and Genetics SB RAS Novosibirsk; Novosibirsk

Email: info@eco-vector.com
Russian Federation

A. V. Sakharov

Research Institute of Traumatology and Orthopedics; Institute of Cytology and Genetics SB RAS

Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Novosibirsk; Novosibirsk

References

  1. Агафонов Ю.А. //Здравоохр. Казахстана. — 1976. — N 6. — С. 52-55.
  2. Григоровский В.В., Улещенко В.А. //Ортопед. травматол.— 1985. — N 3. — С. 21-24.
  3. Balling R. //Cell. — 1988. — Vol. 55. — Р. 531-535.
  4. Bartold P.M., Page R. //Ann. Biochem. — 1985. — N 150. — P. 320-324.
  5. Bitter T., Muir H.M. //Ibid. — 1962. — N 4. — P. 330-334.
  6. Blanco G., Coulton G.R., Biggin A. et al. //J. Hum. Mol. Genet. — 2001. — N 10. — P. 9-16.
  7. Deutsch U., Dressier G.R., Gruss P. //Cell. — 1988. — Vol. 53, N 4. — P. 617-625.
  8. Dietrich S., Gruss P. //Dev. Biol. — 1995. — N 167. — P. 529-548.
  9. Duhl D.M., Stevens M.E., Vrieling H. et al. //Development. — 1994. — Vol. 120, N 6. — P. 1695-1708.
  10. Joseph A., Buckwaiter M.D., Canalis E. et al. //Am. Acad. Orthop. Surg.: Annual Meeting. — 1996.
  11. Manne J. et al. //Proc. Natl. Acad. Sci. — 1995. — Vol. 92. — P. 4721-4724.
  12. Michaud E.J., Bultman S.J., Kiebig M.L. et al. //Proc. Natl. Acad. Sci. USA. — 1994. — Vol. 91, N 7. — P. 2562- 2566.
  13. Revel M., Andre-Deshays C., Roudier R. et al. //Clin. Orthop. — 1992. — N 279. — P. 303-309.
  14. Venn G., Mason R.M. //Biochem. J. — 1986. — Vol. 234, N 2. — P. 475-479.
  15. Venn G., Sims T., Mason R.M. //Biosci. Rep. — 1988. — Vol. 8, N 4. — P. 315-322.
  16. Walther C., Guenet J.L., Simon D. et al. //Genomics. — 1991. — N 2. — P. 424-434.
  17. Wegner W. //Tierarztl. Prax. Supp. — 1988. — N 3. — P. 36-39.
  18. Wilm B., Dahl E., Peters H. et al. //Proc. Natl. Acad. Sci. — 1995. — Vol. 92. — P. 8692-8697.

Supplementary files

Supplementary Files
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1. JATS XML
2. Fig. 1. Kyphotic deformity of the spine in an experimental 1.5-month-old mouse.

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3. Fig. 2. Kyphotic deformity of the spine in an experimental 6-month-old mouse.

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4. Fig. 3. Slight kyphotic deformity of the thoracic spine in a 14-day-old embryo (stained with hematoxylin and eosin, magnification 200).

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5. Fig. 4. Hale reaction in the ventral sections of the cartilaginous blastoma of a 14-day-old embryo (magnitude 200).

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6. Fig. 5. Ultrastructure of chondroblasts in the proliferation zone of the ventral growth plate of the vertebral body of a 1.5-month-old mouse (electron diffraction pattern, magnification 500).

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7. Fig. 6. Detection of SDH and NADH in the form of rare granules in the cytoplasm of chondroblasts of the proliferating layer of the ventral growth plate of the vertebral body (NADI reaction, magn. 200).

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8. Fig. 7. Violation of the architectonics of chondroblasts in the ventral growth plate of the vertebral bodies of a 3-month-old mouse (Stedman reaction, magn. 200).

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9. Fig. 8. Schmorl's hernia in the central parts of the growth plate of the vertebral bodies of a 3-month-old mouse (stained with hematoxylin and eosin, magnification 150).

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