Conceptual model of the pathogenesis of osteochondropathy of the spine

Cover Page

Cite item

Full Text

Abstract

The new direction in study of spine osteochondropathy pathogenesis was worked out from the point of systemic approach. The disease is considered as continuous dysplastic-dystrophic process. The base of this process is a structural anomaly of the end-plates of vertebral body that changes morphogenesis of the vertebral segment. Subsequent clinical course is determined by anatomic-biomechanic characteristics of the affected zone, peculiarities of spine configuration in the saggital plane as well as by the variants of disorders in vertebral body shape formation.

About the authors

N. A. Korzh

Institute of Pathology of the Spine and Joints. M.I. Sitenko

Email: info@eco-vector.com
Ukraine, Kharkiv

A. M. Prodan

Institute of Pathology of the Spine and Joints. M.I. Sitenko

Email: info@eco-vector.com
Ukraine, Kharkiv

V. A. Kolesnichenko

Institute of Pathology of the Spine and Joints. M.I. Sitenko

Author for correspondence.
Email: info@eco-vector.com
Ukraine, Kharkiv

References

  1. Битнер М.К. //Актуальные вопросы остеохондроза позвоночника. — Киев, 1991. — С. 5.
  2. Колесниченко В.А. Остеохондропатия позвоночника. Ранняя диагностика и прогнозирование течения заболевания: Автореф. дис. ... д-ра мед. наук. — Киев, 2001.
  3. Системы надежности клетки /Под ред. Д.М. Гродзинского. — Киев, 1977.
  4. Хвисюк Н.И., Маковоз Е.М., Мителева З.М., Волков Е.Б. //Ортопед. травматол. — 1982. — N 10. — С. 48-54.
  5. Цивьян Я.Л., Бурухин А.А. Патология дегенерирующего межпозвонкового диска. — Новосибирск, 1988.
  6. Аli R.M., Green D.W., Patel Т.С. //Curr. Opin. Pediatr. — 1999. — Vol. 11, N 2. — P. 70-75.
  7. Antoniou J., Goudsouzian N.M., Heathfield T.F. et al. //Spine. — 1996. — Vol. 21. — P. 1153-1161.
  8. Ascani E., Borelli P., la Rossa G. et al. //Le Cifosi. — 1982.— Vol. 5. — P. 181-197.
  9. Aufdermaur M. //Clin. Orthop. — 1961. — N 154. — P. 166-174.
  10. Bogduk N. //Med. J. Austral. — 1976. — Vol. 1, N 23. — P. 878-881.
  11. De Bruto-Marques P.R. //Arch. Neuropsychiat. — 1994. — Vol. 53. — P. 439-442.
  12. Hascall V.C., Heinegard D. //J. Biol. Chem. — 1974. — Vol. 249. — P. 4242-4249.
  13. Hutton W.C., Toribatake Y., Elmer W.A. et al. //Spine. — 1998. — Vol. 23, N 23. — P. 2524-2537.
  14. Ippolito E., Ponseti I.V. //J. Bone Jt Surg. — 1981. — Vol. 63A. — P. 175-182.
  15. Lyons G., Eisenstein S.M., Sweet M.B.E. //Biochem. Biophus. Acta. — 1981. — Vol. 673, N 4. — P. 443-453.
  16. Masataro H. //J. Jap. Orthop. Ass. — 1978. — Vol. 52, N 5. — P. 625-639.
  17. Mathies H., Otte P., Viliaumey J., Dixon A. Klassification der Erkrankungen des Bewegungsapparates. — Switzerland, 1987.
  18. Muir H. //Aust. N. Z. J. Med. — 1978. — Vol. 8, Suppl. 1. — P. 1-5.
  19. Muir H. //Sem. Arthritis and Rheum. — 1981. — Vol. 11, N 1, Suppl. 1. — P. 7-10.
  20. Sairyo K., Goel V.K., Grober L.J. et al. //Spine. — 1998. — Vol. 23. — P. 1442-1446.
  21. Tertti M., Paajanen H., Laato M. et al. //Ibid. — 1991. — Vol. 16. — P. 629-634.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. General scheme of pathogenetic and sanogenetic mechanisms in dysplastic diseases of the spine.

Download (741KB)
Indexing metadata
3. Fig. 2. Pathogenesis of osteochondropathy of the spine at the level of the tissue system (conceptual model).

Download (828KB)
Indexing metadata
4. Fig. 3

Download (788KB)
Indexing metadata
5. Fig. 4. Pathogenesis of osteochondropathy at the level of the vertebral motor segment system (conceptual model).

Download (679KB)
Indexing metadata
6. Fig. 5. Fibrosis of the L3-4 disc ("natural" stabilization of the segment with Schmorl's hernia of the L4 vertebra).

Download (606KB)
Indexing metadata
7. Fig. 6. Disadaptation in the system of the vertebral motor segment: a — with hyperhydration of the nucleus pulposus matrix (intradiscal displacements of the nucleus L3-4 of the intervertebral disc, extrusion of L4-5, L5-S1 discs); b — with dehydration of the nucleus pulposus matrix (instability of L3_4, L4_5 segments).

Download (863KB)
Indexing metadata
8. Fig. 7. Pathogenesis of osteochondropathy at the level of the spinal system (conceptual model).

Download (768KB)
Indexing metadata
9. Fig. 8. Detailed clinical picture of osteochondropathy: L4-5 disc herniation, instability of L3-4, L4-5 segments, increased stenosis of the spinal canal at the level of L3-4, L4-5 segments during extension (a - flexion, b - extension).

Download (427KB)
Indexing metadata
10. Fig. 9. Isthmic spondylolisthesis (a) and elongation spondylolisthesis (b) of the L5 vertebra in osteochondropathy.

Download (1MB)
Indexing metadata

Copyright (c) 2003 Eco-Vector



Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).