Modeling of Posttraumatic Changes in Knee Joint in Animal Experiments


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Abstract

The purpose of the work was to create the model of posttraumatic changes in the knee joint for the study of changes in the injured joint and elaboration of surgical and conservative methods acting on such changes. Experiments were conducted in three equal groups of animals (4 sheep in each group). Round injuries with 5 mm diameter and various depths were inflicted to the bearing surface of the medial femoral condyle. The animals were sacrificed in 1, 3 and
6 months after operation using narcosis overdosage. The obtained data were analyzed by anatomic- morphologic and histochemical methods. Formed posttraumatic structures in the articular cartilage and subchondral bone are constant and may be considered as signs of deforming arthrosis. According to the depth of injury and morphologic changes in the involved cartilaginous and bone articular tissues three degrees of osteoarthrosis are marked out. In every degree the injured joint may be used as a model for the choice of adequate therapy.

About the authors

S P Mironov

ЦИТО

академик РАН и РАМН, профессор, доктор мед. наук, директор; ЦИТО

N P Omel'yanenko

ЦИТО

профессор, доктор мед. наук, руководитель лаборатории соединительной ткани с группой клинической генетики; ЦИТО

V V Trotsenko

ЦИТО

профессор, доктор мед. наук, советник директора ЦИТО по науке; ЦИТО

I N Karpov

ЦИТО

канд. мед. наук, старший науч. сотр. отделения лучевой диагностики; ЦИТО

Anton Pavlovich Kurpyakov

ЦИТО

Email: kurpyakov@mail.ru
врач травматолог-ортопед лаборатории соединительной ткани с группой клинической генетикиТел.: 8 (926) 521-05-91; ЦИТО

S P Mironov

N P Omel'yanenko

V V Trotsenko

I N Karpov

A P Kurpyakov

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