Modeling of a Different Volume Spinal Cord Injury in Rats and Methods for Evaluation of Lost Functions Restoration (part 2)


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Abstract

The purpose of the study was to work out the methods for somatosensory evoked potentials registration under conditions of nerve paths injury in experiment. Evoked potentials were recorded in laboratory animals divided into 5 groups according to the volume of injury inflicted by the technique worked through previously. Potentials were recorded prior to intervention and on 1st, 7th, 14th, 21st, 30th and 45th postoperative day. On the 1st day sharp decrease of potential amplitudes was observed in groups with incomplete spinal cord injury. In groups with complete spinal cord injury no potentials were recorded. Slight restoration of nerve conductivity was observed only in rats with 50% spinal cord transection. Study results showed the efficacy of the technique in the assessment of spinal cord tissues conductivity and confirmed the absence of spontaneous nerve paths restoration after more than 50% of spinal cord transection.

About the authors

S. P Mironov

Central Institute of Traumatology and Orthopaedics named after N.N. Priorov

доктор мед. наук, профессор, академик РАН и РАМН, директор ЦИТО

S. V Kolesov

Central Institute of Traumatology and Orthopaedics named after N.N. Priorov

доктор мед. наук, профессор, зав. отделением патологии позвоночника ЦИТО

G. A Stepanov

Central Institute of Traumatology and Orthopaedics named after N.N. Priorov

доктор мед. наук, профессор, науч. сотр. ЦИТО

M. L Sazhnev

Central Institute of Traumatology and Orthopaedics named after N.N. Priorov

Email: mak.sajnev@yandex.ru
канд. мед. наук, врач отделения патологии позвоночника ЦИТО; Тел.: 8 (495) 450-44-51, 8 (916) 460-98-78. 127299, Москва, ул. Приорова, д. 10, ЦИТО

S. P Gubin

Kurnakov Institute of General and Inorganic Chemistry, Moscow, Russia

доктор мед. наук, профессор, зав. лабораторией химии наноматериалов ИОНХ РАН

Yu. V Ioni

Kurnakov Institute of General and Inorganic Chemistry, Moscow, Russia

канд. мед. наук, науч. сотр. лаборатории химии наноматериалов ИОНХ РАН

V. G Motin

Central Institute of Traumatology and Orthopaedics named after N.N. Priorov

доктор мед. наук, старший науч. сотр. группы экспериментальной травматологии и ортопедии ЦИТО

A. A Panteleev

Central Institute of Traumatology and Orthopaedics named after N.N. Priorov

ординатор ЦИТО

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