Regenerative medicine and orthobiological drugs possibilities in upper limb diseases treatment: Literature review
- Authors: Greben A.I.1,2, Eremin P.S.3, Byalik J.V.3, Kostromina E.Y.3, Parsadanyan G.K.3, Markov P.A.3, Afanasiev A.V.3, Greben T.N.3
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Affiliations:
- Pirogov Russian National Research Medical University
- National Medical Research Center for Rehabilitation and Balneology
- Bauman City Clinical Hospital № 29
- Issue: Vol 30, No 1 (2023)
- Pages: 111-126
- Section: Reviews
- URL: https://journals.rcsi.science/0869-8678/article/view/254196
- DOI: https://doi.org/10.17816/vto322818
- ID: 254196
Cite item
Full Text
Abstract
The analyses of regenerative medicine progress, stem cell biology, and platelet rich plasma growth factor mechanisms of action have pushed many researchers to use orthobiological drugs in their clinical practice. This review aimed to present the use of regenerative techniques and orthobiological drugs in the treatment of upper limb diseases. The open electronic database of PubMed (MEDLINE) was used in the search for scientific studies. The literature search was conducted using the keywords «regenerative medicine», «orthobiology», «hand», «wrist joint», «platelet rich plasma», «mesenchymal stem cells», and «stromal-vascular function». The article presents the results and rationale of the use of orthobiological drugs in the treatment of various hand and upper limb pathologies. The use of orthobiological drugs and regenerative techniques in the treatment of upper limb diseases is a safe and promising direction. For the subsequent use of effective cell products, further research is needed to assess their long-term results and development of unified protocols for their use.
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##article.viewOnOriginalSite##About the authors
Anastasiya I. Greben
Pirogov Russian National Research Medical University; National Medical Research Center for Rehabilitation and Balneology
Email: aik-nastya@mail.ru
ORCID iD: 0000-0002-2423-523X
SPIN-code: 5506-1002
resident, junior researcher
Russian Federation, 1, Moskvorechye str., Moscow, 115578; 32, st. New Arbat, 121099 MoscowPetr S. Eremin
Bauman City Clinical Hospital № 29
Email: ereminps@gmail.com
ORCID iD: 0000-0001-8832-8470
SPIN-code: 8597-6596
researcher
Russian Federation, 2, bldg. 4, Hospital Square, 111020 MoscowJuliya V. Byalik
Bauman City Clinical Hospital № 29
Email: yulyabyalik@ya.ru
ORCID iD: 0009-0001-0601-9066
traumatologist-orthopedist
Russian Federation, 2, bldg. 4, Hospital Square, 111020 MoscowElena Yu. Kostromina
Bauman City Clinical Hospital № 29
Email: bioimed07@hotmail.com
ORCID iD: 0000-0002-9728-7938
SPIN-code: 5698-7489
Cand. Sci. (Bio.), senior researcher
Russian Federation, 2, bldg. 4, Hospital Square, 111020 MoscowGajk K. Parsadanyan
Bauman City Clinical Hospital № 29
Email: gaikparsadanyan@yandex.ru
ORCID iD: 0009-0008-7877-8951
traumatologist-orthopedist
Russian Federation, 2, bldg. 4, Hospital Square, 111020 MoscowPavel A. Markov
Bauman City Clinical Hospital № 29
Email: p.a.markov@mail.ru
ORCID iD: 0000-0002-4803-4803
SPIN-code: 7493-5203
senior researcher
Russian Federation, 2, bldg. 4, Hospital Square, 111020 MoscowAleksei V. Afanasiev
Bauman City Clinical Hospital № 29
Email: afaled13@mail.ru
ORCID iD: 0009-0000-8645-6292
MD, Cand. Sci. Med., traumatologist-orthopedist
Russian Federation, 2, bldg. 4, Hospital Square, 111020 MoscowTatiana N. Greben
Bauman City Clinical Hospital № 29
Author for correspondence.
Email: greben72@inbox.ru
ORCID iD: 0000-0002-6001-0804
chief medical officer
Russian Federation, 2, bldg. 4, Hospital Square, 111020 MoscowReferences
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