Regenerative medicine and orthobiological drugs possibilities in upper limb diseases treatment: Literature review

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Abstract

The analyses of regenerative medicine progress, stem cell biology, and platelet rich plasma growth factor mechanisms of action have pushed many researchers to use orthobiological drugs in their clinical practice. This review aimed to present the use of regenerative techniques and orthobiological drugs in the treatment of upper limb diseases. The open electronic database of PubMed (MEDLINE) was used in the search for scientific studies. The literature search was conducted using the keywords «regenerative medicine», «orthobiology», «hand», «wrist joint», «platelet rich plasma», «mesenchymal stem cells», and «stromal-vascular function». The article presents the results and rationale of the use of orthobiological drugs in the treatment of various hand and upper limb pathologies. The use of orthobiological drugs and regenerative techniques in the treatment of upper limb diseases is a safe and promising direction. For the subsequent use of effective cell products, further research is needed to assess their long-term results and development of unified protocols for their use.

About the authors

Anastasiya I. Greben

Pirogov Russian National Research Medical University; National Medical Research Center for Rehabilitation and Balneology

Email: aik-nastya@mail.ru
ORCID iD: 0000-0002-2423-523X
SPIN-code: 5506-1002

resident, junior researcher

Russian Federation, 1, Moskvorechye str., Moscow, 115578; 32, st. New Arbat, 121099 Moscow

Petr S. Eremin

Bauman City Clinical Hospital № 29

Email: ereminps@gmail.com
ORCID iD: 0000-0001-8832-8470
SPIN-code: 8597-6596

researcher

Russian Federation, 2, bldg. 4, Hospital Square, 111020 Moscow

Juliya V. Byalik

Bauman City Clinical Hospital № 29

Email: yulyabyalik@ya.ru
ORCID iD: 0009-0001-0601-9066

traumatologist-orthopedist

Russian Federation, 2, bldg. 4, Hospital Square, 111020 Moscow

Elena Yu. Kostromina

Bauman City Clinical Hospital № 29

Email: bioimed07@hotmail.com
ORCID iD: 0000-0002-9728-7938
SPIN-code: 5698-7489

Cand. Sci. (Bio.), senior researcher

Russian Federation, 2, bldg. 4, Hospital Square, 111020 Moscow

Gajk K. Parsadanyan

Bauman City Clinical Hospital № 29

Email: gaikparsadanyan@yandex.ru
ORCID iD: 0009-0008-7877-8951

traumatologist-orthopedist

Russian Federation, 2, bldg. 4, Hospital Square, 111020 Moscow

Pavel A. Markov

Bauman City Clinical Hospital № 29

Email: p.a.markov@mail.ru
ORCID iD: 0000-0002-4803-4803
SPIN-code: 7493-5203

senior researcher

Russian Federation, 2, bldg. 4, Hospital Square, 111020 Moscow

Aleksei V. Afanasiev

Bauman City Clinical Hospital № 29

Email: afaled13@mail.ru
ORCID iD: 0009-0000-8645-6292

MD, Cand. Sci. Med., traumatologist-orthopedist

Russian Federation, 2, bldg. 4, Hospital Square, 111020 Moscow

Tatiana N. Greben

Bauman City Clinical Hospital № 29

Author for correspondence.
Email: greben72@inbox.ru
ORCID iD: 0000-0002-6001-0804

chief medical officer

Russian Federation, 2, bldg. 4, Hospital Square, 111020 Moscow

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