Ionizing Radiation and Inflammatory Reaction. Formation Mechanisms and Implications
- Autores: Ponomarev D.1, Stepanov A.1, Seleznyov A.1, Ivchenko E.2
-
Afiliações:
- State Scientific Research Test Institute of Military Medicine
- Kirov Military Medical Academy
- Edição: Volume 63, Nº 3 (2023)
- Páginas: 270-284
- Seção: General Radiobiology
- URL: https://journals.rcsi.science/0869-8031/article/view/137686
- DOI: https://doi.org/10.31857/S0869803123030128
- EDN: https://elibrary.ru/YAVIJT
- ID: 137686
Citar
Resumo
Ionizing radiation induces a complex of genetic, biochemical, structural and functional changes in the body. The inflammatory response development is acknowledged as one of the manifestations of systemic bodily response to ionizing radiation exposure, and this response, through the activation of immunity, acts both as protector and leads to the development of undesirable early, delayed and off-target effects. Its underlying molecular and cellular mechanisms are defined by DNA damage, free radical metabolic changes (primarily reactive oxygen and nitrogen species), oxidative stress development, inflammasome activation, “danger signals” release and pro-inflammatory cytokines production. The role of non-apoptotic cell death forms (ferroptosis and pyroptosis) is described in the genesis of post-radiation inflammatory response and subsequent tissue, organ, and system damages. The post-radiation inflammatory reaction’s ability to take form of a time-stable self-sustaining process – that increases the radiation-induced damage severity – due to the presence of a positive feedback between different components of its pathogenesis is noted.
Sobre autores
D. Ponomarev
State Scientific Research Test Institute of Military Medicine
Email: alexseleznov@list.ru
Russia, Saint Petersburg
A. Stepanov
State Scientific Research Test Institute of Military Medicine
Email: alexseleznov@list.ru
Russia, Saint Petersburg
A. Seleznyov
State Scientific Research Test Institute of Military Medicine
Autor responsável pela correspondência
Email: alexseleznov@list.ru
Russia, Saint Petersburg
E. Ivchenko
Kirov Military Medical Academy
Email: alexseleznov@list.ru
Russia, Saint Petersburg
Bibliografia
- Радиационная медицина. Руководство для врачей-исследователей, организаторов здравоохранения и специалистов по радиационной безопасности. Теоретические основы радиационной медицины. Т. 1. М.: Изд. АТ, 2004. 992 с. [Radiacionnaja medicina. Rukovodstvo dlja vrachej-issledovatelej, organizatorov zdravoohranenija i specialistov po radiacionnoj bezopasnosti. Teoreticheskie osnovy radiacionnoj mediciny. V. 1. M.: Izd. AT, 2004. 992 p. (In Russ.)]
- Schaue D., Micewicz E.D., Ratikan J.A. et al. Radiation & Inflammation // Seminars in Radiation Oncology. 2015. V. 25. № 1. P. 4–10. https://doi.org/10.1016/j.semradonc.2014.07.007
- Mukherjee D., Coates Ph.J., Lorimore S.A. et al. Responses to ionizing radiation mediated by inflammatory mechanisms // J. Pathol. 2014. V. 232. № 3. P. 289–99. https://doi.org/10.1002/path.4299
- Multhoff G., Radons J. Radiation, Inflammation, and Immune Responses in Cancer // Front Oncol. 2012. V. 2. P. 58. https://doi.org/10.3389/fonc.2012.00058
- Yahyapour R., Amini P., Rezapour S. et al. Radiation-induced inflammation and autoimmune diseases // Milit. Med. Res. 2018. V. 5. P. 9. https://doi.org/10.1186/s40779-018-0156-7
- Mavragani I.V., Laskaratou D.A., Frey B. et al. Key mechanisms involved in ionizing radiation-induced systemic effects. A current review // Toxicol. Res. (Camb). 2016. V. 5. № 1. P. 12–33. https://doi.org/10.1039/c5tx00222b
- Тимофеев-Ресовский Н.В., Савич А.В., Шальнов М.И. Введение в молекулярную радиобиологию (физико-химические основы). М.: Медицина, 1981. 320 с. [Timofeev-Resovskij N.V., Savich A.V., Shal’nov M.I. Vvedenie v molekuljarnuju radiobiologiju (fiziko-himicheskie osnovy). M.: Medicina, 1981. 320 p. (In Russ.)]
- Azzam E.I., Jay-Gerin J.-P., Pain D. Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury // Cancer Lett. 2012. V. 327. P. 48–60. https://doi.org/10.1016/j.canlet.2011.12.012
- Gorbunov N.V., Sharma P. Protracted oxidative altera-tions in the mechanism of hematopoietic acute radiation syndrome // Antioxidants (Basel). 2015 V. 4. № 1. P. 134–52. https://doi.org/10.3390/antiox4010134
- Долин П.И. Время жизни промежуточных состояний, возникающих при действии излучений на водные растворы // Роль перекисей и кислорода в начальных стадиях радиобиологического эффекта. М.: Изд-во АН СССР, 1960. С. 20–25. [Dolin P.I. Vremja zhizni promezhutochnyh sostojanij, voznikajushhih pri dejstvii izluchenij na vodnye rastvory // Rol’ perekisej I kisloroda v nachal’nyh stadijah radiobiolo-gicheskogo effekta. M.: Izd-vo AN USSR, 1960. P. 20–25. (InRuss.)]
- Кузин А.М. О роли образования перекисей при действии радиации на биологические объекты // Роль перекисей и кислорода в начальных стадиях радиобиологического эффекта. М.: Изд-во АН СССР, 1960. С. 3–8. [Kuzin A.M. O roli obrazovanija perekisej pri dejstvii radiacii na biologicheskie ob’ekty // Rol’ perekiseji kisloroda v nachal’nyh stadijah radiobiologicheskogo effekta. M.: Izd-vo AN USSR, 1960. P. 3–8. (In Russ.)
- Adjemian S., Oltean T., Martens S. et al. Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death // Cell Death Dis. 2020. V. 11. № 11. P. 1003. https://doi.org/10.1038/s41419-020-03209-y
- Оксидативный стресс и воспаление: патогенетическое партнерство: Монография / Под ред. О. Г. Хурцилавы, Н. Н. Плужникова, Я. А. Накатиса. СПб.: Изд-во СЗГМУ им. И. И. Мечникова, 2012. 340 с. [Oksidativnyj stress i vospalenie: patogeneticheskoe partnerstvo: Monografija / Pod red. O. G. Hurcilavy, N. N. Pluzhnikova, Ja. A. Nakatisa. SPb.: Izdatel’stvo SZGMU im. I. I. Mechnikova, 2012. 340 p. (In Russ.)]
- Мартусевич А.К., Карузин К.А. Оксидативный стресс и его роль в формировании дезадаптации и патологии // Биорадикалы и антиоксиданты. 2015. Т. 2. № 2. С. 5–18. [Martusevich A.K., Karuzin K.A. Oksidativnyj stress i ego rol' v formirovanii dezadaptacii i patologii // Bioradikaly i antioksidanty. 2015. V. 2. № 2. P. 5–18. (In Russ.)]
- Chen Y., Li Y., Huang L. et al. Antioxidative stress: inhibiting reactive oxygen species production as a cause of radioresistance and chemoresistance // Oxidat. Med. Cell. Longevity. 2021. V. 2021. P. 6620306. https://doi.org/10.1155/2021/6620306
- Kajarabille N., Latunde-Dada G.O. Programmed cell-death by ferroptosis: antioxidants as mitigators // Int. J. Mol. Sci. 2019. V. 20. № 19. P. 4968. https://doi.org/10.3390/ijms20194968
- Кузник Б.И., Линькова Н.С., Ивко О.М. Оксидативный стресс, старение и короткие пептиды // Успехи физиол. наук. 2021. Т. 52. № 2. С. 13–20. [Kuznik B.I., Linkova N.S., Ivko O.M. Oxidative stress, aging and short peptides // Progress in Physiological Science. 2021. V. 52. № 2. P. 13–20. (In Russ.)]. https://doi.org/10.31857/S0301179821020041
- Gaschlera M.M., Stockwellb B.R. Lipid peroxidation in cell death // Biochem. Biophys. Res. Commun. 2017. V. 482. № 3. P. 419–425. https://doi.org/10.1016/j.bbrc.2016.10.086
- Citrin D.E., Mitchell J.B. Mechanisms of normal tissue injury from irradiation // Semin. Radiat. Oncol. 2017. V. 27. № 4. P. 316–324. https://doi.org/10.1016/j.semradonc.2017.04.001
- Li P., Chang M. Roles of PRR-mediated signaling pathways in the regulation of oxidative stress and inflammatory diseases // Int. J. Mol. Sci. 2021. V. 19; 22. № 14. P. 7688. https://doi.org/10.3390/ijms22147688
- Rock K.L., Kono H. The inflammatory response to cell death // Ann. Rev. Pathol. Mechanisms Diseases. 2008. V. 3. P. 99–126. https://doi.org/10.1146/annurev.pathmechdis.3.121806. 151456
- Литвицкий П.Ф. Воспаление // Вопр. совр. педиатрии. 2006. Т. 6. № 3. С. 48–51 [Litvitsky P.F. Inflammation // Curr. Pediatr. 2006. V. 6. № 3. P. 48–51. (In Russ.)].
- Schaue D., McBride W.H. Links between innate immunity and normal tissue radiobiology // J. Radiat. Res. 2010. V. 173. № 4. P. 406–417.https://doi.org/10.1667/RR1931.1
- Farhood B., Ashrafizadeh M., Khodamoradi E. et al. Targeting of cellular redox metabolism for mitigation of radiation injury // Life Sci. 2020. V. 250. P. 117570. Available at: https://doi.org/ May 24, 2020.https://doi.org/10.1016/j.lfs.2020.117570.Accessed
- Hill R.P., Zaidi A., Mahmood J. et al. Investigations into the role of inflammation in normal tissue response to irradiation // Radiother. Oncol. 2011. V. 101. № 1. P. 73–79. https://doi.org/10.1016/j.radonc.2011.06.017
- Sun L., Inaba Y., Sato K. et al. Dose-dependent decrease in anti-oxidant capacity of whole blood after irradiation: A novel potential marker for biodosimetry // Sci. Rep. 2018. V. 8. P. 7425. https://doi.org/10.1038/s41598-018-25650-y
- Sun L., Inaba Y., Sogo Y. et al. Total body irradiation causes a chronic decrease in antioxidant levels // Sci. Rep. 2021. V. 11. № 1. P. 6716. https://doi.org/10.1038/s41598-021-86187-1
- Singh V.K., Beattie L.A., Seed T.M. Vitamin E: toco-pherols and tocotrienols as potential radiation countermeasures // J. Radiat. Res. 2013. V. 54. № 6. P. 973–988. https://doi.org/10.1093/jrr/rrt048
- Greenberger J., Kagan V., Bayir H. et al. Antioxidant approaches to management of ionizing irradiation injury // Antioxidants. 2015. V. 4. P. 82–101. https://doi.org/10.3390/antiox4010082
- Hofer M., Hoferová Z., Falk M. Pharmacological mo-dulation of radiation damage. Does it exist a chance for other substances than hematopoietic growth factors and cytokines? // Int. J. Mol. Sci. 2017. V. 18. № 7. P. 1385. https://doi.org/10.3390/ijms18071385
- Yang W.S., Stockwell B.R. Ferroptosis: death by lipid peroxidation // Trends Cell Biol. 2016. V. 26. № 3. P. 165–176. https://doi.org/10.1016/j.tcb.2015.10.014
- Hirschhorn T., Stockwell B.R. The development of the concept of ferroptosis // Free Radical Biol. Med. 2019. V. 133. P. 130–143. https://doi.org/10.1016/j.freeradbiomed.2018.09.043
- Galluzzi L., Vitale I., Aaronson S.A. et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 // Cell Death Differentiation. 2018. V. 25. № 3. P. 486–541. https://doi.org/10.1038/s41418-017-0012-4
- Xie Y., Hou W., Song X. et al. Ferroptosis: process and function // Cell Death Differentiation. 2016. V. 23. № 3. P. 369–379. https://doi.org/10.1038/cdd.2015.158
- Stockwell B.R., Friedmann Angeli J.P., Bayir H. et al. Ferroptosis: a regulated cell death nexus linking meta-bolism, redox biology, and disease // Cell. 2017. V. 171. № 2. P. 273–285. https://doi.org/10.1016/j.cell.2017.09.021
- Ye L.F., Chaudhary K.R., Zandkarimi F. et al. Radiation-induced lipid peroxidation triggers ferroptosis and synergizes with ferroptosis inducers // ACS Chem. Biol. 2020. V. 15. № 2. P. 469–484. https://doi.org/10.1021/acschembio.9b00939
- Zhang X., Xing X., Liu H. et al. Ionizing radiation indu-ces ferroptosis in granulocyte-macrophage hematopoietic progenitor cells of murine bone marrow // Int. J. Radiat. Biol. 2020. V. 96. № 5. P. 584–595. https://doi.org/10.1080/09553002.2020.1708993
- Zhang X., Tian M., Li X. et al. Hematopoietic protection and mechanisms of ferrostatin-1 on hematopoietic acute radiation syndrome of mice // Int. J. Radiat. Biol. 2021. V. 97. № 4. P. 464–473. https://doi.org/10.1080/09553002.2021.1876956
- Thermozier S., Hou W., Zhang X. et al. Anti-ferroptosis drug enhances total-body irradiation mitigation by drugs that block apoptosis and necroptosis // J. Radiat. Res. 2020. V. 193. № 5. P. 435–450. https://doi.org/10.1667/RR15486.1
- Cohen-Jonathan E., Bernhard E.J., McKenna W.G. How does radiation kill cells? // Curr. Opin. Chem. Biol. 1999. V. 3. № 1. P. 77–83. https://doi.org/10.1016/S1367-5931(99)80014-3
- Verheij M., Bartelink H. Radiation-induced apoptosis // Cell Tissue Res. 2000, V. 301. № 1. P. 133–42. https://doi.org/10.1007/s004410000188
- Shinomiya N. New concepts in radiation-induced apoptosis: “premitotic apoptosis” and “postmitotic apoptosis” // J. Cell Mol. Med. 2001. V. 5. № 3. P. 240–253. https://doi.org/10.1111/j.1582-4934.2001.tb00158
- Elmore S. Apoptosis: A review of programmed cell death // Toxicol. Pathol. 2007. V. 35. № 4. P. 495–516. https://doi.org/10.1080/01926230701320337
- Черешнев В.А., Цыган В.Н., Одинак М.М. и др. Фармакологическое регулирование программированной гибели клеток / Под ред. В.А. Черешнева. СПб.: Наука, 2011. 255 с. [Chereshnev V.A., Tsygan V.N., Odinak M.M. et al. Pharmacological regulation of programmed cell death / Ed. V.A. Chereshnev. St. Petersburg: Nauka, 2011. 255 p. (In Russ.)]
- Cao X., Wen P., Fu Y. et al. Radiation induces apoptosis primarily through the intrinsic pathway in mammalian cells // Cell Signal. 2019. V. 62. P. 109337. https://doi.org/10.1016/j.cellsig.2019.06.002
- Lee K.-H., Kang T.-B. The molecular links between cell death and inflammasome // Cells. 2019. V. 8. № 9. P. 1057. https://doi.org/10.3390/cells8091057
- D’Arcy M.S. Cell death: a review of the major forms of apoptosis, necrosis and autophagy // Cell Biol. Int. 2019. V. 43. № 6. P. 582–592. https://doi.org/10.1002/cbin.11137
- Kroemer G., Galluzzi L., Vandenabeele P. et al. Classification of cell death recommendations of the Nomenclature Committee on Cell Death 2009 // Cell Death Differentiat. 2009. V. 16. № 1. P. 3–11. https://doi.org/10.1038/cdd.2008.150
- Gudipaty S.A., Conner Ch.M., Rosenblatt J. et al. Unconventional ways to live and die: cell death and survi-val in development, homeostasis, and disease // Ann. Rev. Cell Develop. Biol. 2018. V. 34. P. 311–332. https://doi.org/10.1146/annurev-cellbio-100616-060748
- Lorimore S.A., Coates Ph.J., Scobie G.E. et al. Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects? // Oncogen. 2001. V. 20. P. 7085–7095. https://doi.org/10.1038/sj.onc.1204903
- Taylor R.C., Cullen S.P., Martin S.J. Apoptosis: controlled demolition at the cellular level // Nat. Rev. Mol. Cell Biol. 2008. V. 9. № 3. P. 231–241. https://doi.org/10.1038/nrm2312
- Silva M.T., do Vale A., dos Santos N.M.N. Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications // Apoptosis. 2008. V. 13. № 4. P. 463–482. https://doi.org/10.1007/s10495-008-0187-8
- Bergsbaken T., Fink S.L., Cookson B.T. Pyroptosis: host cell death and inflammation // Nat. Rev. Microbiol. 2009. V. 7. № 2. P. 99–109. https://doi.org/10.1038/nrmicro2070
- Lu F., Lan Zh., Xin Zh. et al. Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseases // J. Cell Physiol. 2020. V. 235. № 4. P. 3207–3221. https://doi.org/10.1002/jcp.29268
- Walle L.V., Lamkanfi M. Pyroptosis // Curr. Biol. 2016. V. 26. № 13. P. R568–R572. https://doi.org/10.1016/j.cub.2016.02.019
- Yu P., Zhang X., Liu N. et al. Pyroptosis: mechanisms and diseases // Signal Transduct. Target Ther. 2021. V. 6. № 1. P. 128. https://doi.org/10.1038/s41392-021-00507-5
- He W.-T., Wan H., Hu L. et al. Gasdermin D is an exe-cutor of pyroptosis and required for interleukin-1β secretion // Cell Res. 2015. V. 25. № 12. P. 1285–1298. https://doi.org/10.1038/cr.2015.139
- Stoecklein V.M., Osuka A., Ishikawa Sh. et al. Radiation exposure induces inflammasome pathway activation in immune cells // J. Immunol. 2015. V. 194. № 3. P. 1178–1189. https://doi.org/10.4049/jimmunol.1303051
- Liu Y.-G., Chen J.-K., Zhang Z.-T. et al. NLRP3 inflammasome activation mediates radiation-induced pyroptosis in bone marrow-derived macrophages // Cell Death Disease. 2017. V. 8. № 2. P. e2579. https://doi.org/10.1038/cddis.2016.460
- Liao H., Wang H., Rong X. et al. Mesenchymal stem cells attenuate radiation-induced brain injury by inhi-biting microglia pyroptosis // Biomed. Res. Inte. 2017. P. 1948985. https://doi.org/10.1155/2017/1948985
- Гемпельман Л., Лиско Г., Гофман Д. Острый лучевой синдром: изучение 9 случаев и обзор проблемы / Под ред. А. Бурназяна. М.: Изд-во Иностр. лит-ры, 1954. 290 с. [Gempel’man L., Lisko G., Gofman D. Ostryj luchevoj sindrom: izuchenie 9 sluchaev I obzor problem / Pod red. A. Burnazjana. M.: Izd-vo inostrannoj literatury, 1954. 290 p. (In Russ.)]
- McBride W.H., Chiang Chi.-Sh., Olson J.L. et al. A Sense of Danger From Radiation // Radiat. Res. 2004. V. 162. № 1. P. 1–19. https://doi.org/10.1667/rr3196
- Богданова И.М. Иммунологические механизмы сепсиса и новые подходы к его терапии // Клин. и эксперим. морфология. 2014. Т. 3. № 11. С. 52–58. [Bogdanova I.M. Immunological mechanisms of sepsis and new approaches to its treatment // Clinical and experimental morphology. 2014. V. 3. № 11. P. 52–58. (In Russ.)]
- Schaefer L. Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns // J. Biol. Chem. 2014. V. 289. № 51. P. 35237–35245. https://doi.org/10.1074/jbc.R114.619304
- Ratikan J.A., Micewicz E.D., Xie M.W. et al. Radiation takes its Toll // Cancer Lett. 2015. V. 368. № 2. P. 238–245. https://doi.org/10.1016/j.canlet.2015.03.031
- Черешнев В.А., Гусев Е.Ю. Иммунологические и патофизиологические механизмы системного воспаления // Мед. иммунология. 2012. Т. 14. № 1–2. С. 9–20. [Chereshnev V.A., Gusev E.Ju. Immunolo-gicheskie i patofiziologicheskie mehanizmy sistemnogo vospalenija // Medicinskaja immunologija. 2012. V. 14. № 1–2. P. 9–20. (In Russ.)]
- Shi Y., Evans J., Rock K. Molecular identification of a danger signal that alerts the immune system to dying cells // Nature. 2003. V. 425. P. 516–521. https://doi.org/10.1038/nature01991
- Netea M.G., Balkwill F., Honchol M. et al. A guiding map for inflammation // Nat. Immunol. 2017. V. 18. № 8. P. 826–831.https://doi.org/10.1038/ni.3790
- Тухватулин А.И., Логунов Д.Ю., Щербинин Д.Н. и др. Toll‑подобные рецепторы и их адапторные молекулы. Обзор // Биохимия. 2010. Т. 75. № 9. С. 1224–1243. [Tukhvatulin A.I., Logunov D.Y., Shcherbinin D.N. et al. Toll-like receptors and their adapter molecules // Biochemistry (Moscow). 2010. V. 75. № 9. P. 1098–1114. (In Russ.)]
- Piccinini A.M., Midwood K.S. DAMPening inflammation by modulating tlr signaling // Mediators Inflamm. 2010. P. 672395. https://doi.org/10.1155/2010/672395
- Bianchi M.E. DAMPs, PAMPs and alarmins: all we need to know about danger // J. Leukocyte Biol. 2007. V. 81. № 1. P. 1–5. https://doi.org/10.1189/jlb.0306164
- Бакунина Л.С., Литвиненко И.В., Накатис Я.А. и др. Сепсис: пожар и бунт на тонущем в шторм корабле: монография. В 3 ч. Ч. I. Триггеры воспаления. Рецепция триггеров воспаления и сигнальная трансдукция / Под ред. Н.Н. Плужникова, С.В. Чепура, О.Г. Хурцилава. СПб.: Изд-во СЗГМУ им. И.И. Мечникова, 2018. 232 с. [Bakunina L.S., Litvinenko I.V., Nakatis Y.A. et al. Sepsis: pozhar i bunt na tonuschem v shtorm korable: Recepciya trigerov vos-palenia i signal`naya transdukciya / Pod redakciej N.N. Pluzhnikova, S.V. Chepura, O.G. Xurcilava. Saint Peterburg: Izdatel`stvo SZGMU imeni I.I. Mechnikova, 2018. 232 p. (In Russ.)]
- Takeuchi O., Akira Sh. Pattern Recognition Receptors and Inflammation // Cell. 2010. V. 140. № 6. P. 805–820. https://doi.org/10.1016/j.cell.2010.01.022
- Ковальчук Л.В., Хорева М.В., Никонова А.С. Распознающие рецепторы врожденного иммунитета (NLR, RLRи CLR) // Журн. микробиологии, эпидемиологии и иммунобиологии. 2011. № 1. С. 93–100. [Koval’chuk L.V., Khoreva M.V., Nikonova A.S. Recognition receptors of innate immunity (NLR, RLR, AND CLR) // J. Microbiol. Epidemiol. Immunobiol. 2011. № 1. 93–100. (In Russ.)]
- Успенская Ю.А., Комлева Ю.К., Пожиленкова Е.А. и др. Лиганды RAGE-белков: роль в межклеточной коммуникации и патогенезе воспаления // Вестн. РАМН. 2015. Т. 70. № 6. С. 694–703. [Uspenskaya Yu.A., Komleva Yu.K., Pozhilenkova E.A. et al. Ligands of RAGE-Proteins: Role in Intercellular Communication and Pathogenesis of Inflammation // Vestnik Rossiiskoi Akademii Meditsinskikh Nauk (Annals of the Russian Academy of Medical Sciences). 2015. V. 70. № 6. P. 694–703 (In Russ.)]. https://doi.org/10.15690/vramn566
- Schaue D., Kachikwu E.L., McBride W.H. Cytokines in Radiobiological Responses: A Review // Radiat. Res. 2012. V. 178. № 6: 505–523. https://doi.org/10.1667/RR3031.1
- Janssens S., Tschopp J. Signals from within: the DNA-damage-induced NF-kappaB response // Cell Death Different. 2006. V. 13. № 5. P. 773–84. https://doi.org/10.1038/sj.cdd.4401843
- Janssens S., Tinel A., Lippens S. et al. PIDD mediates NF-κB activation in response to DNA damage // Cell. 2005. V. 123. № 6. P. 1079–1092.
- Lin Y., Bai L, Chen W. et al. The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy // Exp. Opin. Therap. Targets. 2010. V. 14. № 1. P. 45–55. https://doi.org/10.1517/14728220903431069
- Zhang Q., Lenardo M.J., Baltimore D. 30 Years of NF-κB: A blossoming of relevance to human pathobiology // Cell. 2017. V. 168. № 1–2. P. 37–57. https://doi.org/10.1016/j.cell.2016.12.012
- Di Maggio F.M., Minafra L., Forte G.I. et al. Portrait of inflammatory response to ionizing radiation treatment // J. Inflamm. (Lond). 2015. V. 12. P. 14. https://doi.org/10.1186/s12950-015-0058-3
- Pulsipher A., Savage J.R., Kennedy T.P. et al. GM-1111 reduces radiation-induced oral mucositis in mice by targeting pattern recognition receptor-mediated inflammatory signaling // PLoS One. 2021. V. 16. № 3. P. e0249343. https://doi.org/10.1371/journal.pone.0249343
- Dent P., Yacoub A., Fisher P.B. et al. MAPK pathways in radiation responses // Oncogene. 2003. V. 22. № 37. P. 5885–96. https://doi.org/10.1038/sj.onc.1206701
- Munshi A., Ramesh R. Mitogen-activated protein kina-ses and their role in radiation response // Genes Cancer. 2013. V. 4. № 9–10. P. 401–408. https://doi.org/10.1177/1947601913485414
- Meng Q., Karamfilova Zaharieva E., Sasatani M. et al. Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation // Redox Rep. 2021. V. 26. № 1. P. 160–169. https://doi.org/10.1080/13510002.2021.1971363
- Евдокимовский Э.В., Губина Н.Е., Ушакова Т.Е. и др. Изменение соотношения мтДНК/яДНК в сыворотке крови после рентгеновского облучения мышей в различных дозах // Радиац. биология. Радиоэкология. 2012. Т. 52. № 6. С. 565–571. [Evdokimovsky E.V., Gubina N.E., Ushakova T.E. et al. Changes of Mitochondrial DNA/Nuclear DNA Ratio in the Blood Serum Following X-Ray Irradiation of Mice at Various Doses // Radiation biology. Radioecology. 2012. V. 52. № 6. P. 565–571. (InRuss.)]
- Евдокимовский Э.В., Губина Н.Е., Абдуллаев С.А., и др. Изменения в уровне метилирования ДНК, а также экспрессии генов в митохондриях разных отделов головного мозга крыс, облученных протонами 150 МэВ // Мат. междунар. конф. “Современные вопросы радиационной генетики”. Дубна, 2019. С. 53–54. [Evdokimovskij Je.V., Gubina N.E., Abdullaev S.A. et al. Izmenenija v urovne metilirovanija DNK, a takzhej ekspressii genov v mitohondrijah raznyh otdelov golovnogo mozga krys, obluchennyh protonami 150 Mjev. Sovremennye voprosy radiacionnoj genetiki // Materialy rossijskoj konferencii s mezhdu-narodnym uchastiem. Dubna, 2019. P. 53–54. (In Russ.)]
- Yang L., Hu M., Lu Y. et al. Inflammasomes and the maintenance of hematopoietic homeostasis: new perspectives and opportunities // Molecules. 2021. V. 26. № 2. P. 309. https://doi.org/10.3390/molecules26020309
- Wei J., Wang H., Wang H. et al. The role of NLRP3 inflammasome activation in radiation damage // Biomed. Pharmacotherap. 2019. V. 118. P. 109217. https://doi.org/10.1016/j.biopha.2019.109217
- Huang Sh., Che J., Chu Q. et al. The Role of NLRP3 inflammasome in radiation-induced cardiovascular injury // Front. Cell Develop. Biol. 2020. V. 8. P. 140. https://doi.org/10.3389/fcell.2020.00140
- Колмычкова К.И., Желанкин А.В., Карагодин В.П. и др. Митохондрии и воспаление // Патол. физиология и эксперим. терапия. 2016. Т. 60. № 4. С. 114–121 [Kolmychkova K.I., Zhelankin A.V., Karagodin V.P. et al. Mitochondria and inflammation // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2016. V. 60. № 4. P. 114–121. (In Russ.)]
- Zhang Q., Raoof M., Chen Y. et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury // Nature. 2010. V. 464. № 7285. P. 104–107. https://doi.org/10.1038/nature08780
- Патрушев М.В., Патрушева В.Е., Касымов В.А. и др. Элиминация мтДНК из митохондрий и активация ее репликации в клетках тканей облученных мышей // Цитология. 2006. Т. 48. № 8. С. 684–691. [Patrushev M.V., Patrusheva V.E., Kasymov V.А. et al. Release of mtDNA from mitochondria and activation of its replication in tissues of irradiated mice // Tsitologiya. 2006. V. 48. № 8. P. 684–691. (In Russ.)]
- Picca A., Calvani R., Coelho-Junior H.J. et al. Cell death and inflammation: the role of mitochondria in health and disease // Cells. 2021. V. 10. № 3. P. 537. https://doi.org/10.3390/cells10030537
- De Gaetano A., Solodka K., Zanini G. et al. Molecular mechanisms of mtDNA-mediated inflammation // Cells. 2021. V. 10. № 11. P. 2898. https://doi.org/10.3390/cells10112898
- Kong C., Song W., Fu T. Systemic inflammatory response syndrome is triggered by mitochondrial damage // Mol. Med. Rep. 2022. V. 25. № 4. P. 147. https://doi.org/10.3892/mmr.2022.12663
- Riley J.S., Tait S.W.G. Mitochondrial DNA in inflammation and immunity // EMBO Rep. 2020. V. 21. № 4. P. e49799. https://doi.org/10.15252/embr.201949799
- Guo H., Callaway J.B., Ting J. P.-Y. Inflammasomes: mechanism of action, role in disease, and therapeutics // Nat. Med. 2015. V. 21. № 7. P. 677–687.
- Sharma D., Kanneganti Th.-D. The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation // J. Cell Biol. 2016. V. 213. № 6. P. 617–629. https://doi.org/10.1083/jcb.201602089
- He Y., Hara H., Núñez G. Mechanism and regulation of NLRP3 inflammasome activation // Trends Biochem. Sci. 2016. V. 41. № 12. P. 1012–1021. https://doi.org/10.1016/j.tibs.2016.09.002
- Vanaja S., Rathinam V.K., Fitzgerald K.A. Mechanisms of inflammasome activation: recent advances and no-vel insights // Trends Cell Biol. 2015. V. 25. № 5. P. 308–315. https://doi.org/10.1016/j.tcb.2014.12.009
- Man S.M., Kanneganti Th.-D. Regulation of inflammasome activation // Immunol. Rev. 2015. V. 265. № 1. P. 6–21. https://doi.org/10.1111/imr.12296
- Гариб Ф.Ю., Ризопулу А.П., Кучмий А.А., и др. Инактивация инфламмасом патогенами регулирует воспаление (обзор) // Биохимия. 2016. Т. 81. № 11. С. 1578–1592. [Garib F.Yu., Rizopulu A.P., Kuchmiy A.A. et al. Inactivation of inflammasomes by pathogens regulates inflammation // Biochemistry (Moscow). 2016. V. 81. № 11. P. 1326–1339. (In Russ.)]
- Гариб Ф.Ю., Ризопулу А.П. Инфламмасомы и воспаление // Рос. иммунол. журн. 2017. Т. 11 (20). № 4. С. 620–626. [Garib F.Yu., Rizopulu A.P. Inflammasomes and inflammation // Russian Journal of Immunology (Rossiyskiy Immunologicheskiy Zhurnal). 2017. V. 11 (20). № 4. P. 620–626. (In Russ.)]
- Богданова И.М. Инфламмасомы: внутриклеточные регуляторы противоинфекционного и воспалительного ответа в системе врожденного иммунитета // Клин. и эксперим. морфология. 2016. Т. 1. № 17. С. 63–69. [Bogdanova I.M. Inflammasomes: intracellular regulators of anti-infectious and inflammatory responses in the innate immune system // Clin. Exp. Morphology. 2016. V. 1. № 17. P. 63–69. (In Russ.)]
- Кувачева Н.В., Моргун А.В., Хилажева Е.Д. и др. Формирование инфламмасом: новые механизмы регуляции межклеточных взаимодействий и секреторной активности клеток // Сиб. мед. обозрение. 2013. № 5 (83). С. 3–10. [Kuvacheva N.V., Morgun A.V., Hilazheva E.D. Inflammasomes forming: new mechanisms of intercellular interactions regulation and secretory activity of the cells // Siberian Me-dical Review. 2013. № 5 (83). P. 3–10. (In Russ.)]
- Ghaemi-Oskouie F., Shi Y. The role of uric acid as an endogenous danger signal in immunity and inflammation // Curr. Rheumatol. Rep. 2011. V. 3. № 2. P. 160–166. https://doi.org/10.1007/s11926-011-0162-1
- Gao J., Peng Sh., Shan X. et al. Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis // Cell Death Diseases. 2019. V. 10. № 12. P. 957. https://doi.org/10.1038/s41419-019-2195-8
- Xiao J., Wang Ch., Yao J.-Ch. et al. Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells // PLoS Biol. 2020. V. 18. № 8. P. e3000807. https://doi.org/10.1371/journal.pbio.3000807
- Sohn S.-H., Lee J.M., Park S. et al. The inflammasome accelerates radiation-induced lung inflammation and fibrosis in mice // Environ. Toxicol. Pharmacol. 2015. V. 39. № 2. P. 917–926. https://doi.org/10.1016/j.etap.2015.02.019
- Цыган В.Н., Бубнов В.А., Цыган Н.В. и др. Врожденный иммунитет и активация атерогенеза // Воен.-мед. журн. 2016. Т. 337. № 3. С. 47–54. [Tsygan V.N., Bubnov V.A., Tsygan N.V. et al. The innate immunity and activation of the atherogenesis // Voenno-med. zhurn. (J. Mil. Med). 2016. V. 337. № 3. P. 47–54. (In Russ.)]
- Zhao W., Robbins M.E.C. Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications // Curr. Med. Chem. 2009. V. 16. № 2. P. 130–143. https://doi.org/10.2174/092986709787002790