Foreshadowing the Future of Genetic Engineering and Radiobiology: 100 Years From the Beginning of N.V. Timofeeff-Ressovsky’s Scientific Work

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

The year 2021 was marked with a significant date – 100 years ago, brilliant radiobiologist and geneticist N.V. Timofeeff-Ressovsky started his scientific work. Among the new directions developed by him from 1921 to 1981 were physical biology, basic principles of genetic engineering, amplifier principle, and population radiobiology. It is noteworthy that many of his ideas were developed in the former Department of Radiation Genetics and General Radiobiology of the Institute of Medical Radiology in Obninsk, which is now called the Experimental Sector of the A. Tsyb Medical Radiological Research Centrе. Our work reveals the interconnections of Timofeeff-Ressovsky’s works with the activities of his contemporaries and productive ideas of today.

About the authors

I. D. Klabukov

A. Tsyb National Medical Research Radiological Center of the Ministry of Health of the Russian Federation; Рeoples’ Friendship University of Russia (RUDN University); Obninsk Institute of Nuclear Power Engineering of the National Research Nuclear University MEPhI

Author for correspondence.
Email: ilya.klabukov@gmail.com
Russia, Obninsk; Russia, Moscow; Russia, Obninsk

A. O. Yakimova

A. Tsyb National Medical Research Radiological Center of the Ministry of Health of the Russian Federation

Email: ilya.klabukov@gmail.com
Russia, Obninsk

D. S. Baranovskii

A. Tsyb National Medical Research Radiological Center of the Ministry of Health of the Russian Federation; Рeoples’ Friendship University of Russia (RUDN University)

Email: ilya.klabukov@gmail.com
Russia, Obninsk; Russia, Moscow

E. M. Yatsenko

A. Tsyb National Medical Research Radiological Center of the Ministry of Health of the Russian Federation

Email: ilya.klabukov@gmail.com
Russia, Obninsk

V. A. Petrov

A. Tsyb National Medical Research Radiological Center of the Ministry of Health of the Russian Federation

Email: ilya.klabukov@gmail.com
Russia, Obninsk

L. P. Zhavoronkov

A. Tsyb National Medical Research Radiological Center of the Ministry of Health of the Russian Federation

Email: ilya.klabukov@gmail.com
Russia, Obninsk

S. A. Ivanov

A. Tsyb National Medical Research Radiological Center of the Ministry of Health of the Russian Federation; Рeoples’ Friendship University of Russia (RUDN University)

Email: ilya.klabukov@gmail.com
Russia, Obninsk; Russia, Moscow

P. V. Shegai

A. Tsyb National Medical Research Radiological Center of the Ministry of Health of the Russian Federation; P. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centrе of the Ministry of Health of the Russian Federation

Email: ilya.klabukov@gmail.com
Russia, Obninsk; Russia, Moscow

A. D. Kaprin

A. Tsyb National Medical Research Radiological Center of the Ministry of Health of the Russian Federation; Рeoples’ Friendship University of Russia (RUDN University); P. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centrе of the Ministry of Health of the Russian Federation

Email: ilya.klabukov@gmail.com
Russia, Obninsk; Russia, Moscow; Russia, Moscow

References

  1. Тимофеев-Ресовский Н.В. Избранные труды / Под ред. акад. О.Г. Газенко и акад. РАМН В.И. Иванова. М.: Медицина, 1996. 480 с. [Timofeev-Resovsky N.V. Selected Works / Eds Acad. O.G. Gazenko and Acad RAMS V.L. Ivanova Moskov: Izdatel’stvo Medicine, 1996. 480p. (In Russ.)]
  2. Видные отечественные ученые в области радиобиологии, радиационной медицины и безопасности (Биобиблиографический справочник) / Под общ. ред. Л.А. Ильина, А.С. Самойлова, И.Б. Ушакова. М.: ФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА России, 2021. 616 с. [Vidnye otechestvennye uchenye v oblasti radiobiologii, radiacionnoj mediciny i bezopasnosti (biobibliograficheskij spravochnik) / Eds L.A. Il’ina, A.S. Samojlova, I.B. Ushakova. M.: FGBU GNC FMBC im. A.I. Burnazjana FMBA Rossii, 2021. 616 p. (In Russ.)]
  3. Бабков В.В., Саканян Е.С. Николай Тимофеев-Ресовский / Под ред. акад. Б.С. Соколов. М.: Памятники исторической мысли, 2002. 672 с. [Babcov V.V., Sakanyan E.S. Nikolay Timofeev-Resovsky / Ed. Acad. B.S. Sokolov. Moskov: Izdatel’stvo Monuments of historical thought, 2002. 672 p. (In Russ.)]
  4. Ратнер В. А. Укус издыхающей рептилии (из архива А.А. Ляпунова) // Информ. вестник ВОГиС. 2000. Т. 4. № 13–14. С. 7. [Ratner V.A. Bite of Dying Reptille (from the archive of A.A. Lipunov) // Information Bulletin of VOGiS. 2000. V. 4. № 13–14. P. 7–7. (In Russ.)]
  5. Тимофеев-Ресовский Н.В., Свирежев Ю.М. О генетическом полиморфизме в популяциях. Экспериментально-теоретическое исследование // Генетика. 1967. Т. 3. № 10. С. 152–166. [Timofeev-Ressovsky N.V., Svirezhev Yu.M. On genetic polymorphism in populations. Experimental-theoretical study // Genetics. 1967. V. 3. № 10. P. 152–166. (In Russ.)]
  6. Zimmer K.G. N.W. Timoféeff-Ressovsky 1900–1981 // Mutation Research / Fundamental and Molecular Me-chanisms of Mutagenesis. 1982. V. 106. № 2. P. 191–193. https://doi.org/10.1016/0027-5107(82)90100-2
  7. Тимофеев-Ресовский Николай Владимирович. Беседы. Режим доступа: http://oralhistory.ru/members/timofeev-resovskiy-n-v (29.01.2023) [Timofeev-Resovskij Nikolaj Vladimirovich. Besedy. Access: http://oralhistory.ru/members/timofeev-resovskiy-n-v (29.01.2023)]
  8. Тимофеев-Ресовский Н.В. Структурные уровни биологических систем. Системные исследования. Методологические проблемы. Ежегодник. М., 1970. С. 80–91. [Timoféeff-Ressovsky N.W Structural levels of biological systems. System Research. Methodological problems: Yearbook. M., 1970. P. 80–91. (In Russ.)] https://elibrary.ru/item.asp?id=32524057
  9. Timoféeff-Ressovsky N.W., Zimmer K.G., & Delbrück. Über die Natur der Genmutation und der Genstruktur // Nachr. Ges. Wiss. Gottingen VI. N. F.1935. V. 1. P. 189–245.
  10. Schrödinger E. What is Life? The Physical Aspect of the Living Cell. Cambridge: University Press, 1944. [Русский перевод: Э. Шрёдингер. Что такое жизнь? Физический аспект живой клетки. 3-е изд. Ижевск: РХД, 2002.]
  11. Perutz M. Physics and the riddle of life // Nature. 1987. V. P. 326: 555–558. https://doi.org/10.1038/326555a0
  12. Тимофеев-Ресовский Н.В. Некоторые проблемы радиационной биогеоценологии // Из истории медицинской мысли. М., 1996. С. 416–454. [Timofeev-Resovskij N.V. Nekotorye problemy radiacionnoj biogeocenologii // Iz istorii medicinskoj mysli. Moskva, 1996. P. 416–454 (In Russ.)]
  13. Timoféeff-Ressovsky N.W., Zimmer K.G., & Delbrück. Über die Natur der Genmutation und der Genstruktur // Nachr. Ges. Wiss. Gottingen VI. N. F. 1935. V. 1. P. 189–245.
  14. Timofeeff-Ressovsky N.W. The Experimental Production of Mutations // Biological Reviews. 1934. V. 9. № 4. P. 411–457. https://doi.org/10.1111/j.1469-185x.1934.tb01255.x
  15. Jackson D.A., Symons R.H., Berg P. (1972). Biochemical method for inserting new genetic information into DNA of Simian Virus 40: circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli // Proc. Nat. Acad. Sci. 1972. V. 69. № 10. P. 2904–2909.
  16. Газенко О.Г., Тимофеев-Ресовский Н.В., Шепелев Е.Я. Учение о биосфере и космическая биология // Человек. 2000. № 4. С. 9–10. [Gazenko O.G., Timofeev-Resovsky N.W., Shepelev E.Ya. Teaching about the biosphere and space biology // Man. 2000. № 4. P. 9–10 (In Russ.)]
  17. Ratner V.A. Nikolay Vladimirovich Timofeeff-Ressovsky (1900–1981): twin of the century of genetics // Genetics. 2001. V. 158. № 3. P. 933–939.
  18. Вернадский В.И. О концентрации радия живыми организмами // Докл. АН СССР. Л., 1929. Т. 24–А. № 2. С. 33–34. [Vernadsky V.I On the concentration of radium in living organisms // DAN USSR. L., 1929. V. 24–A. № 2. P. 33–34. (In Russ.)]
  19. Карако П.С. Космические воззрения Н.В. Тимофеева-Ресовского и их место в системе русского космизма // Проблемы онто-гносеологического обоснования математических и естественных наук. 2019. Т. 10. С. 16–29. [Karako P.S. Cosmic views of N.V. Timofeev-Resovsky and their place in the system of Russian cosmism // Problems of onto-epistemolo-gical substantiation of mathematical and natural sciences. 2019. V. 10. P. 16–29. (In Russ.)]
  20. Cavalieri L.F. New Strains of Life or Death // New York Times Magazine. 22 Aug 1976. P. 8–9. https://www.nytimes.com/1976/08/22/archives/new-strains-of-lifeor-death-scientists-have-learned-to-rearrange.html
  21. Microbiome Induced Space Suit. Режим доступа: https://2021.igem.org/Team:MEPhI (дата доступа: 29.01.2023) [Microbiome Induced Space Suit. Access on: https://2021.igem.org/Team:MEPhI (29.01.2023)]

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2.

Download (835KB)
Indexing metadata
3.

Download (535KB)
Indexing metadata
4.

Download (211KB)
Indexing metadata

Copyright (c) 2023 И.Д. Клабуков, А.О. Якимова, Д.С. Барановский, Е.М. Яценко, В.А. Петров, Л.П. Жаворонков, С.А. Иванов, П.В. Шегай, А.Д. Каприн

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies