miRNA-122 as a new player in cardiovascular disease

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Identification of a new significant level of regulation of gene activity using small non-coding molecules of ribonucleic acid — miRNA — can be confidently considered as one of the most outstanding discoveries of modern science It became clear that the suppression of gene expression caused by miRNA is an extremely important universal mechanism widely involved in most intracellular signaling pathways. Current data on the role of miRNA-122 in the development of cardiovascular diseases is included in this review. miRNA-122 is positioned as a promising biological marker in cardiovascular pathology. miRNA-122 promotes inflammation, oxidative stress, and apoptosis in cardiovascular disease. Clinical and experimental studies support the pathophysiological role of miRNA-122 in fibrosis and cardiac dysfunction. Overexpression of miRNA-122 exacerbates the loss of autophagy and enhances angiotensin II-mediated inflammation, apoptosis, fibrosis, and cardiac dysfunction. miRNA-122 should be considered not only as a promising diagnostic and prognostic tool, but also as a target for modern medicine. Inhibition of miRNA-122 results in antifibrotic, antiapoptotic, anti-inflammatory, antioxidant, and pro-autophagic effects. Further study is required to evaluate the real diagnostic and therapeutic potential of miRNA-122.

作者简介

Amina Alieva

Pirogov Russian National Research Medical University (Pirogov Medical University)

编辑信件的主要联系方式.
Email: amisha_alieva@mail.ru
ORCID iD: 0000-0001-5416-8579
SPIN 代码: 2749-6427

MD, Cand. Sci. (Med.), associate professor

俄罗斯联邦, 1, Ostrovityanova street, 117997, Moscow

Natalia Teplova

Pirogov Russian National Research Medical University (Pirogov Medical University)

Email: teplova.nv@yandex.ru
ORCID iD: 0000-0002-7181-4680
SPIN 代码: 9056-1948

MD, Dr. Sci. (Med.), professor

俄罗斯联邦, 1, Ostrovityanova street, 117997, Moscow

Elena Reznik

Pirogov Russian National Research Medical University (Pirogov Medical University)

Email: elenaresnik@gmail.com
ORCID iD: 0000-0001-7479-418X
SPIN 代码: 3494-9080

MD, Dr. Sci. (Med.), professor

俄罗斯联邦, 1, Ostrovityanova street, 117997, Moscow

Irina Baykova

Pirogov Russian National Research Medical University (Pirogov Medical University)

Email: 1498553@mail.ru
ORCID iD: 0000-0003-0886-6290
SPIN 代码: 3054-8884

MD, Cand. Sci. (Med.), associate professor

俄罗斯联邦, 1, Ostrovityanova street, 117997, Moscow

Lidiya Shnakhova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: shnakhova_l_m@staff.sechenov.ru
ORCID iD: 0000-0003-3000-0987

MD

俄罗斯联邦, Moscow

Gayane Totolyan

Pirogov Russian National Research Medical University (Pirogov Medical University)

Email: tgg03@mail.ru
ORCID iD: 0000-0002-9922-5845
SPIN 代码: 1441-7740

MD, Cand. Sci. (Med.), associate professor

俄罗斯联邦, 1, Ostrovityanova street, 117997, Moscow

Ramiz Valiev

The Loginov Moscow Clinical Scientific Center

Email: radiosurgery@bk.ru
ORCID iD: 0000-0003-1613-3716
SPIN 代码: 2855-2867

MD, Cand. Sci. (Med.)

俄罗斯联邦, Moscow

Elina Skripnichenko

Pirogov Russian National Research Medical University (Pirogov Medical University)

Email: elkaskrip@gmail.com
ORCID iD: 0000-0001-6321-8419

graduate student

俄罗斯联邦, 1, Ostrovityanova street, 117997, Moscow

Irina Kotikova

Pirogov Russian National Research Medical University (Pirogov Medical University)

Email: kotikova.ia@mail.ru
ORCID iD: 0000-0001-5352-8499
SPIN 代码: 1423-7300

student

俄罗斯联邦, 1, Ostrovityanova street, 117997, Moscow

Igor Nikitin

Pirogov Russian National Research Medical University (Pirogov Medical University)

Email: igor.nikitin.64@mail.ru
ORCID iD: 0000-0003-1699-0881

MD, Dr. Sci. (Med.), professor

俄罗斯联邦, 1, Ostrovityanova street, 117997, Moscow

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2. Fig. 1. The role of miRNA-122 in cardiovascular disease: NT-proBNP— N-terminal pro b-type natriuretic peptide, ГМК — smooth muscle cells.

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