miRNA-122 as a new player in cardiovascular disease
- Authors: Alieva A.M.1, Teplova N.V.1, Reznik E.V.1, Baykova I.E.1, Shnakhova L.M.2, Totolyan G.G.1, Valiev R.K.3, Skripnichenko E.A.1, Kotikova I.A.1, Nikitin I.G.1
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Affiliations:
- Pirogov Russian National Research Medical University (Pirogov Medical University)
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- The Loginov Moscow Clinical Scientific Center
- Issue: Vol 28, No 6 (2022)
- Pages: 451-463
- Section: Reviews
- URL: https://journals.rcsi.science/0869-2106/article/view/232884
- DOI: https://doi.org/10.17816/medjrf111180
- ID: 232884
Cite item
Abstract
Identification of a new significant level of regulation of gene activity using small non-coding molecules of ribonucleic acid — miRNA — can be confidently considered as one of the most outstanding discoveries of modern science It became clear that the suppression of gene expression caused by miRNA is an extremely important universal mechanism widely involved in most intracellular signaling pathways. Current data on the role of miRNA-122 in the development of cardiovascular diseases is included in this review. miRNA-122 is positioned as a promising biological marker in cardiovascular pathology. miRNA-122 promotes inflammation, oxidative stress, and apoptosis in cardiovascular disease. Clinical and experimental studies support the pathophysiological role of miRNA-122 in fibrosis and cardiac dysfunction. Overexpression of miRNA-122 exacerbates the loss of autophagy and enhances angiotensin II-mediated inflammation, apoptosis, fibrosis, and cardiac dysfunction. miRNA-122 should be considered not only as a promising diagnostic and prognostic tool, but also as a target for modern medicine. Inhibition of miRNA-122 results in antifibrotic, antiapoptotic, anti-inflammatory, antioxidant, and pro-autophagic effects. Further study is required to evaluate the real diagnostic and therapeutic potential of miRNA-122.
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##article.viewOnOriginalSite##About the authors
Amina M. Alieva
Pirogov Russian National Research Medical University (Pirogov Medical University)
Author for correspondence.
Email: amisha_alieva@mail.ru
ORCID iD: 0000-0001-5416-8579
SPIN-code: 2749-6427
MD, Cand. Sci. (Med.), associate professor
Russian Federation, 1, Ostrovityanova street, 117997, MoscowNatalia V. Teplova
Pirogov Russian National Research Medical University (Pirogov Medical University)
Email: teplova.nv@yandex.ru
ORCID iD: 0000-0002-7181-4680
SPIN-code: 9056-1948
MD, Dr. Sci. (Med.), professor
Russian Federation, 1, Ostrovityanova street, 117997, MoscowElena V. Reznik
Pirogov Russian National Research Medical University (Pirogov Medical University)
Email: elenaresnik@gmail.com
ORCID iD: 0000-0001-7479-418X
SPIN-code: 3494-9080
MD, Dr. Sci. (Med.), professor
Russian Federation, 1, Ostrovityanova street, 117997, MoscowIrina E. Baykova
Pirogov Russian National Research Medical University (Pirogov Medical University)
Email: 1498553@mail.ru
ORCID iD: 0000-0003-0886-6290
SPIN-code: 3054-8884
MD, Cand. Sci. (Med.), associate professor
Russian Federation, 1, Ostrovityanova street, 117997, MoscowLidiya M. Shnakhova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: shnakhova_l_m@staff.sechenov.ru
ORCID iD: 0000-0003-3000-0987
MD
Russian Federation, MoscowGayane G. Totolyan
Pirogov Russian National Research Medical University (Pirogov Medical University)
Email: tgg03@mail.ru
ORCID iD: 0000-0002-9922-5845
SPIN-code: 1441-7740
MD, Cand. Sci. (Med.), associate professor
Russian Federation, 1, Ostrovityanova street, 117997, MoscowRamiz K. Valiev
The Loginov Moscow Clinical Scientific Center
Email: radiosurgery@bk.ru
ORCID iD: 0000-0003-1613-3716
SPIN-code: 2855-2867
MD, Cand. Sci. (Med.)
Russian Federation, MoscowElina A. Skripnichenko
Pirogov Russian National Research Medical University (Pirogov Medical University)
Email: elkaskrip@gmail.com
ORCID iD: 0000-0001-6321-8419
graduate student
Russian Federation, 1, Ostrovityanova street, 117997, MoscowIrina A. Kotikova
Pirogov Russian National Research Medical University (Pirogov Medical University)
Email: kotikova.ia@mail.ru
ORCID iD: 0000-0001-5352-8499
SPIN-code: 1423-7300
student
Russian Federation, 1, Ostrovityanova street, 117997, MoscowIgor G. Nikitin
Pirogov Russian National Research Medical University (Pirogov Medical University)
Email: igor.nikitin.64@mail.ru
ORCID iD: 0000-0003-1699-0881
MD, Dr. Sci. (Med.), professor
Russian Federation, 1, Ostrovityanova street, 117997, MoscowReferences
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