Diagnostic and therapeutic aspects of neuregulin-1: A review
- Authors: Alieva A.M.1, Teplova N.V.1, Reznik E.V.1, Strangul E.I.1, Baikova I.E.1, Kotikova I.A.1, Shikhova Y.A.2, Khachirova E.A.1, Valiev R.K.3, Nikitin I.G.1
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Affiliations:
- Pirogov Russian National Research Medical University (Pirogov Medical University)
- Scientific-Clinical Center №2 of the Russian Research Center for Surgery named after Academician B.V. Petrovsky
- The Loginov Moscow Clinical Scientific Center
- Issue: Vol 29, No 2 (2023)
- Pages: 127-140
- Section: Reviews
- URL: https://journals.rcsi.science/0869-2106/article/view/131871
- DOI: https://doi.org/10.17816/medjrf115277
- ID: 131871
Cite item
Abstract
In recent decades, the prospect of using a biomarker strategy for early personalized diagnosis of cardiovascular pathologies has been actively explored. The use of new markers appears promising, and the search for an “ideal” marker is actively ongoing, which will make it possible to understand various mechanisms of cardiovascular diseases. In recent years, scientists have actively focused on studying the role of neuregulin-1 as a laboratory biological marker in cardiac pathology. Neuregulins belong to a superfamily of epidermal growth factors that are synthesized by the vascular endothelium in response to ischemia, adrenergic stimulation, and oxidative stress.
Several studies have shown the potentially important diagnostic and prognostic value of assessing neuregulin-1 as a biological marker. Thus, further scientific and clinical studies will demonstrate the possibility of using this marker as an additional laboratory tool for diagnosing, risk stratifying, and predicting cardiovascular events in patients with cardiovascular pathology. The therapeutic effect of recombinant neuregulin-1 on reducing morbidity and mortality in patients with cardiac disorders require more detailed assessments.
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##article.viewOnOriginalSite##About the authors
Amina M. Alieva
Pirogov Russian National Research Medical University (Pirogov Medical University)
Email: amisha_alieva@mail.ru
ORCID iD: 0000-0001-5416-8579
SPIN-code: 2749-6427
MD, Cand. Sci. (Med.), associate professor
Russian Federation, 1 Ostrovityanova street, 117997, MoscowNatalia V. Teplova
Pirogov Russian National Research Medical University (Pirogov Medical University)
Email: teplova.nv@yandex.ru
ORCID iD: 0000-0002-7181-4680
SPIN-code: 9056-1948
MD, Dr. Sci. (Med.), professor
Russian Federation, 1 Ostrovityanova street, 117997, MoscowElena V. Reznik
Pirogov Russian National Research Medical University (Pirogov Medical University)
Email: elenaresnik@gmail.com
ORCID iD: 0000-0001-7479-418X
SPIN-code: 3494-9080
MD, Dr. Sci. (Med.), professor
Russian Federation, 1 Ostrovityanova street, 117997, MoscowElena I. Strangul
Pirogov Russian National Research Medical University (Pirogov Medical University)
Email: strangul@mail.ru
ORCID iD: 0000-0001-5928-7569
senior laboratory assistant
Russian Federation, 1 Ostrovityanova street, 117997, MoscowIrina E. Baikova
Pirogov Russian National Research Medical University (Pirogov Medical University)
Email: 1498553@mail.ru
ORCID iD: 0000-0003-0886-6290
SPIN-code: 3054-8884
MD, Cand. Sci. (Med.), assistant professor
Russian Federation, 1 Ostrovityanova street, 117997, MoscowIrina A. Kotikova
Pirogov Russian National Research Medical University (Pirogov Medical University)
Email: kotikova.ia@mail.ru
ORCID iD: 0000-0001-5352-8499
student
Russian Federation, 1 Ostrovityanova street, 117997, MoscowYuliya A. Shikhova
Scientific-Clinical Center №2 of the Russian Research Center for Surgery named after Academician B.V. Petrovsky
Email: shikyula@mail.ru
ORCID iD: 0000-0003-4688-4385
MD, Cand. Sci. (Med.)
Russian Federation, MoscowElvira A. Khachirova
Pirogov Russian National Research Medical University (Pirogov Medical University)
Email: elchik09@mail.ru
ORCID iD: 0000-0003-2523-8907
MD, Cand. Sci. (Med.)
Russian Federation, 1 Ostrovityanova street, 117997, MoscowRamiz K. Valiev
The Loginov Moscow Clinical Scientific Center
Email: radiosurgery@bk.ru
ORCID iD: 0000-0003-1613-3716
SPIN-code: 2855-2867
MD, Cand. Sci. (Med.)
Russian Federation, MoscowIgor G. Nikitin
Pirogov Russian National Research Medical University (Pirogov Medical University)
Author for correspondence.
Email: igor.nikitin.64@mail.ru
ORCID iD: 0000-0003-1699-0881
SPIN-code: 3595-1990
MD, Dr. Sci. (Med.), professor
Russian Federation, 1 Ostrovityanova street, 117997, MoscowReferences
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