THE CONTENT OF SERUM CYTOTOXINS UNDER LIVER CIRRHOSIS OF VIRAL ETIOLOGY AT VARIOUS STAGES OF COMPENSATION

The study was implemented concerning the level of interleukins 2 and 6 (IL-2 and IL-6), tumor necrosis factor alpha (TNF-α) under hepatic cirrhosis (HC) of viral etiology classes А, В, С according Child-Pugh. The purpose was to evaluate level of serum cytokinemies and their relationship under HC of viral etiology depending on class of severity according Child-Pugh and level of portal pressure. The cytokines concentration was determined using technique of solid-phase enzyme-linked immunosorbent assay. It is established that against the background of decreasing of compensation of HC occurs increasing of serum level of IL-2, IL-6 and TNF-α within the limits of reference values at the exception of level of IL-6 under HC class C. In the given category of patients, level of IL-6 exceeds reference values and is within the limits of 9,94-25,21 pg ̸ml with average concentration 14,89±4,96 pg ̸ml. It is demonstrated that quantitative ratios and degrees of relationships between cytokines are determined by compensation of cirrhosis. The correlation relationships are mostly expressed in the form of feedback between TNF-α and IL-6 (r = 0,499) in case of HC class A. and in the form of direct relation between TNF-α and IL-2 (r = 0,421) in case of HC class B. It is proved that against the background of decreasing of compensation of HC increasing is occurring of serum levels of IL-2, IL-6 and TNF-α within the limits of reference values with the exception of level of IL-6 in case of HC class C. In the given category of patients’ level of IL-6 exceeds reference values and is within limits of 9,94-25,21 pg/ml with average concentration 14,89 4,96 pg/ml.

interleukin-2, interleukin-6, tumor necrosis factor alpha, hepatic cirrhosis