Email this article THE CHARACTERISTICS OF SECRETION OF ADIPONECTIN AND ITS RELATIONSHIP WITH PARTICULAR INDICESOF METABOLISM IN MALES OF ABLE-BODIED AGE IN CASE OF OBESITY
- Authors: Karataeva O.V.1
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Affiliations:
- The Nizhegorodskaya state medical academy of Minzdrav of Russia
- Issue: Vol 23, No 6 (2017)
- Pages: 312-315
- Section: Articles
- URL: https://journals.rcsi.science/0869-2106/article/view/38428
- DOI: https://doi.org/10.18821/0869-2106-2017-23-6-312-315
- ID: 38428
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Abstract
The sampling consisted of 79 examined males of able-bodied age. The arterial hypertension stage I and II was established in 58% of them; obesity of various degree of severity was diagnosed in 63% of them; metabolic syndrome according criteria ATP-III was noted in 46.8% of examined patients. The general clinical and anthropometric examination was carried out. The laboratory analyses included estimation of lipidogram, fasting glycaemia and also hormones adiponectin and insulin with following calculation of index of insulin resistance HOMA-IR (Homeostasis Model Assessment of Insulin Resistance). The study was organized to investigate effecting of obesity on secretion of adiponectin and its relationship with indices of lipidogram and level of insulin resistance. The comparative analysis of groups with and absence of obesity established no significant difference in level of adiponectin and indices of lipidogram. the significant differences were established in the levels of basal insulin hence in value of index NOMA-IR that points to hyperinsulinemia and expressed insulin resistance in patients with obesity. The patients were separated in two groups depending on presence of manifestations of metabolic syndrome: with metabolically healthy obesity and metabolically complicated obesity. The analysis established a significant decreasing of level of adiponectin in the group of metabolically complicated obesity accompanied by insulin resistance, dyslipidemia and increased level of glycaemia. The study established no effect of degree of obesity on decreasing of level of adiponectin. The significant differences between levels of adiponectin in comparison between group without obesity and group of metabolically healthy obesity. The correlation analysis in group with obesity demonstrated back-coupling between level of adiponectin and content of total cholesterol, low density lipoproteins and coefficient of atherogenicity. The comparison of groups according median of adiponectin established significant differences in rate of development of metabolic syndrome and value of coefficient of atherogenicity.
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##article.viewOnOriginalSite##About the authors
Olga V. Karataeva
The Nizhegorodskaya state medical academy of Minzdrav of Russia
Email: olgamichaleva@mail.ru
post-graduate student of the chair of endocrinology and inner diseases the Nizhegorodskaya state medical academy of Minzdrav of Russia, 603005, Nizhniy Novgorod, Russian Federation 603005, Nizhniy Novgorod, Russian Federation
References
- Романцова Т.И. Эпидемия ожирения: очевидные и вероятные причины. Ожирение и метаболизм. 2011; (1): 5-17.
- Шляхто Е.В., Недогода С.В., Конради А.О., Баранова Е.И., Фомин В.В., Верткин А.Л. и др. Концепция новых национальных клинических рекомендаций по ожирению. Российский кардиологический журнал. 2016; (4): 7-13.
- Белоцерковцева Л.Д., Коваленко Л.В., Корнеева Е.В. Жировая ткань и её роль в развитии метаболического синдрома у женщин. Вестник СурГУ. Медицина. 2011; (1): 11-27.
- Кравчун П.Г., Кадыкова О.И., Габисония Т.Н. Роль гормонов жировой ткани в формировании метаболических нарушений у больных с сердечно-сосудистой патологией. Журнал научных публикаций аспирантов и докторантов. 2013; (1): 114-7.
- Никонова Л.В., Тишковский С.В., Гулинская О.В., Дорошкевич И.П., Янец Н.В., Давыдчик Э.В. Метаболическая активность жировой ткани и её роль в формировании инсулинорезистентности. Журнал Гродненского государственного медицинского университета. 2012; (1): 7-9.
- Косыгина А.В. Адипоцитокины в научной и клинической практике. Ожирение и метаболизм. 2011; (1): 32-9.
- Wang Y.Y., Lin S.Y., Chuang Y.H., Chen C.J., Tung K.C., Sheu W.H. Adipose proinflammatory cytokine expression through sympathetic system is associated with hyperglycemia and insulin resistance in a rat ischemic stroke model. Am. J. Physiol. Endocrinol. Metab. 2011; 300(1): E155-63
- Сметнев С.А., Мешков А.Н. Роль пептидных гормонов (адипонектин, лептин, инсулин) в патогенезе атеросклероза. Рациональная фармакотерапия в кардиологии. 2015; 11(5): 522-8.
- Парфенова Н.С., Танянский Д.А. Адипонектин: влияние на метаболические и сердечно-сосудистые нарушения. Артериальная гипертензия. 2013; 19(1): 84-96.
- Grundy S.M., Cleeman J.I., Merz C.N.B., Brewer H.B., Clark L.T., Hunninghake D.B., et al. Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. NCEP Report. Circulation. 2004; 110: 227-39
