Email this article THE METABOLIC DISORDERS IN MEMBRANE OF ERYTHROCYTES AND INSULIN-BINDING ACTIVITY OF BLOOD CELLS IN PATIENTS UNDER OBESITY AND DIABETES MELLITUS TYPE II
- Authors: Mikaelyan N.P.1, Potemkin V.V1
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Affiliations:
- The N.I. Pirogov Russian national research medical university Minzdrav of Russia
- Issue: Vol 23, No 4 (2017)
- Pages: 201-204
- Section: Articles
- URL: https://journals.rcsi.science/0869-2106/article/view/38412
- DOI: https://doi.org/10.18821/0869-2106-2017-23-4-201-204
- ID: 38412
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Abstract
The results of clinical metabolic examination of women with diabetes mellitus type II and patients with obesity degree III-IV testify increasing of level of cholesterol, triglycerides, low density lipoproteins and very low density lipoproteins and also coefficient of atherogenity in comparison with control group. These alterations permit to affirm that diabetes mellitus type II in women also as obesity is accompanied by dislipidemia of atherogenic character. At that, in patients with diabetes mellitus type II more intensive alterations of quantitative composition of lipids, including fat acid composition of blood is established. The obesity and diabetes mellitus type II are accompanied by modification of composition of free and esterified fatty acids of blood erythrocytes, increasing of peroxidation of lipids that can result in alteration of functional activity of membranes and in damage of insulin-binding activity of cyto-membranes. The disorder of metabolism of fatty acids accompanied by increasing of concentration of free radicals and decreasing of activity of enzymes of anti-oxidant defense results in decreasing of insulin-binding activity of cells and disorder of processes of glucose utilization.
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##article.viewOnOriginalSite##About the authors
Nina P. Mikaelyan
The N.I. Pirogov Russian national research medical university Minzdrav of Russia
Email: ninmik@yandex.ru
doctor of biological sciences, professor of the chair of biochemistry and molecular biology of the medical faculty the N.I. Pirogov Russian national research medical university Minzdrav of Russia, 117997, Moscow, Russian Federation 117997, Moscow, Russian Federation
V. V Potemkin
The N.I. Pirogov Russian national research medical university Minzdrav of Russia117997, Moscow, Russian Federation
References
- Шишкова В., Осыченко М. Профилактика метаболических и когнитивных нарушений при ожирении и сахарном диабете типа 2. Врач. 2011; 2(1): 31-4.
- Микаелян Н.П., Потёмкин В.В., Францева Е.Ю., Кулаева И.О. Функциональное состояние мембрано-рецепторного аппарата клеток крови при впервые выявленном сахарном диабете типа 2. Проблемы эндокринологии. 2012; 4(2): 40-1.
- Титов В.Н. Становление в филогенезе, этиология и патогенез синдрома резистентности к инсулину. Отличия от сахарного диабета второго типа. Вестник Российской академии медицинских наук. 2012; 4(1): 65-73.
- Дедов И.И. Сахарный диабет: развитие технологий в диагностике, лечении и профилактике (пленарная лекция). Сахарный диабет. 2010; (3): 6-13.
- Choudhuri S., Dutta D., Chowdhury I.H., Mitra B., Sen A., Mandal L.K. et al. Association of hyperglycemia mediated increased advanced glycation and erythrocyte antioxidant enzyme activity in different stages of diabetic retinopathy. Diabetes Res. Clin. Pract. 2013; 100(3): 376-84.
- Harris W.S., Miller M., Tighe A.P., Davidson M.H., Schaefer E.J. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis. 2008; 197(1): 12-24.
- Микаелян Н.П., Князев Ю.А., Петрухин В.А., Микаелян А.В. Инсулинорецепторное взаимодействие в лимфоцитах и эритроцитах у беременных с гестационным сахарным диабетом. Сахарный диабет. 2006; (1): 15-7
- Yagi K. A simple fluorometric assay for lipoperoxide in blood plasma. Biochem. Med. 1976; 15(2): 212-6
- Королюк М.А., Иванова Л.И., Майорова И.Г., Токарев В.Е. Методы определения активности каталазы. Лабораторное дело. 1988; 25(1): 16-9
- Folch J., Lees M., Sloane Stanley G.H. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 1957; 226(1): 497-509.
- Ichihara K., Fukubayashi Y. Preparation of fatty acid methyl esters for gas-liquid chromatography. J. Lipid Res. 2010; 51(3): 635-40.
- Новгородцева Т.П., Караман Ю.К., Жукова Н.В., Лобанова Е.Г., Антонюк М.В. Особенности состава жирных кислот крови и уровень оксилипинов у пациентов с метаболическим синдромом. Клиническая лабораторная диагностика. 2010; 10(1): 22-5
- Rodríguez-Carrizalez A.D., Castellanos-González J.A., Martínez-Romero E.C., Miller-Arrevillaga G., Villa-Hernández D., Hernández-Godínez P.P. et al. Oxidants, antioxidants and mitochondrial function in non-proliferative diabetic retinopathy. J. Diabetes. 2014; 6(2): 167-75.
- Phinney S.D. Fatty acids, inflammation, and the metabolic syndrome. Am. J. Clin. Nutr. 2005; 82(1): 1151-2.
