THE SIGNIFICANCE OF HIGH-SENSITIVE TROPONIN I UNDER VARIOUS FORMS OF INFECTIOUS ENDOCARDITIS


Cite item

Full Text

Abstract

The study was carried out to analyze dynamics of highly sensitive Troponin I in patients with infectious endocarditis with the purpose of specifying its role in evaluation of myocardium condition and prognosis of disease. The sampling included 241 patients being on treatment in the S.P. Botkin municipal clinical hospital. The article presents characteristics of disease at actual stage, clinical laboratory and instrumental comparisons permitted to establish features and patterns of alterations of hsTnI in patients with primary and secondary infectious endocarditis. The relationship is established between increasing of indicator and clinical expression of infectious toxic syndrome, presence of complications, multi-functional alterations of myocardium and functional class of cardiac insufficiency. It is demonstrated that absence of positive dynamics of marker against the background of therapy is a unfavorable prognostic indication and increases a risk of lethal outcome.The obtained results testify undeniable involvement of cardiac muscle into development of pathological process under infectious endocarditis that alongside with valvular pathology determines severity of cardiac insufficiency and prognosis of disease.

About the authors

T. A Fedorova

The institute of professional education of the I.M. Sechenov first Moscow state medical university of Minzdrav of Russia

119991, Moscow, Russian Federation

Serafima Ya. Tazina

The institute of professional education of the I.M. Sechenov first Moscow state medical university of Minzdrav of Russia

Email: tazin.re@yandex.ru
candidate of medical sciences, associate professor of the chair of therapy the institute of professional education of the I.M. Sechenov first Moscow state medical university of Minzdrav of Russia, 119991, Moscow, Russian Federation 119991, Moscow, Russian Federation

A. N Gerasimov

The institute of professional education of the I.M. Sechenov first Moscow state medical university of Minzdrav of Russia

119991, Moscow, Russian Federation

N. A Semenenko

The institute of professional education of the I.M. Sechenov first Moscow state medical university of Minzdrav of Russia

119991, Moscow, Russian Federation

References

  1. Jerome J.F., Sally C.S., Amanda F.P., Vivian H.C., Vance G.F. Endocarditis trends in the united States demonstrate increasing rates of Staphylococcus aureus: 1999-2008. Arch. Intern. Med. 2012; 172(4): 363-5.
  2. Dayer M.J., Jones S., Prendergast B., Baddour M.L., Lockhart P.B., Thornhill M.H. et al. Incidence of infective endocarditis in England, 2000-13: a secular trend, interrupted time-series analysis. Lancet. 2015; 385(9974): 1219-28.
  3. Тюрин В.П. Инфекционный эндокардит - сохраняющиеся проблемы диагностики и лечения. В кн.: Тезисы докладов XII Московской ассамблеи «Здоровье столицы». М.: 2013; 108-9
  4. Fernández Guerrero M.L., Álvarez B., Manzarbeitia F., Renedo G. Infective endocarditis at autopsy: a review of pathologic manifestations and clinical correlates. Medicine (Baltimore). 2012; 91(3): 152-64.
  5. Murdoch D.R., Corey G.R., Hoen B., Miró J.M., Fowler V.G., Bayer A.S. et al. Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century. Arch. Intern. Med. 2009; 169(5): 463-73.
  6. Федорова Т.А., Тазина С.Я., Семененко Н.А. Роль маркеров воспаления и дисфункции миокарда в диагностике, оценке течения и прогноза при инфекционном эндокардите. Клиническая геронтология. 2014; (6): 12-7

Copyright (c) 2017 Eco-Vector


 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies