The morbidity of obliterating atherosclerosis of arteries of lower extremities in workers of enterprise of nuclear industry


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Abstract

The purpose. The evaluation of indices of morbidity of arteriosclerosis obliterans of arteries of lower extremities in cohort of workers exposed to professional chronic radiation. Material and methods. The retrospective cohort study included 22 377 workers of enterprise of nuclear industry "Maiak" with verified diagnosis of arteriosclerosis obliterans of arteries of lower extremities. The "crude" and standardized indices of morbidity were calculated. The indirect technique of standardization was applied for standardization of indices. The results. In the studied cohort of workers, at the end of period of observation (December 31 2008), 938 cases of arteriosclerosis obliterans of arteries of lower extremities were registered. It is demonstrated that morbidity of arteriosclerosis obliterans of arteries of lower extremities in studied cohort of workers statistically significant depended on gender, attained age, status of smoking, alcohol consumption (in males) and body mass index (in females). The morbidity of arteriosclerosis obliterans of arteries of lower extremities is statistically significant higher in males exposed to chronic external gamma-radiation in total dose higher than 1.0 grays and/or internal alpha-radiation from incorporated plutonium in total dose absorbed by liver dose more than 0.025 grays. Conclusion. The morbidity of arteriosclerosis obliterans of arteries of lower extremities in cohort of workers exposed to professional chronic radiation depended on both non-radiation and radiation factors.

About the authors

Tamara V. Azizova

The Yuzhno-Ural'skiy institute of biophysics of the Federal medical biological agency of Russia

Email: clinic@subi.su
candidate of medical sciences, deputy director the Yuzhno-Ural'skiy' institute of biophysics of the Federal medical biological agency of Russia 456780, Ozersk

K. V Kuznetsova

The Yuzhno-Ural'skiy institute of biophysics of the Federal medical biological agency of Russia

456780, Ozersk

M. V Bannikova

The Yuzhno-Ural'skiy institute of biophysics of the Federal medical biological agency of Russia

456780, Ozersk

M. V Sumina

The Yuzhno-Ural'skiy institute of biophysics of the Federal medical biological agency of Russia

456780, Ozersk

Ya. P Bagaeva

The central medical sanitary department №71 of the Federal medical biological agency of Russia

456780 Ozersk, Russian Rederation

E. V Azizova

The central medical sanitary department №71 of the Federal medical biological agency of Russia

456780 Ozersk, Russian Rederation

N. P Fotyeva

The central medical sanitary department №71 of the Federal medical biological agency of Russia

456780 Ozersk, Russian Rederation

L. N Krupenina

The central medical sanitary department №71 of the Federal medical biological agency of Russia

456780 Ozersk, Russian Rederation

References

  1. Бокерия Л.А., Темрезов М.Б., Борсов М.Х., Коваленко В.И. Прямая реваскуляризация - метод выбора в лечении больных с критической ишемией нижних конечностей. Российский медицинский журнал. 2011; (6): 23-6.
  2. Суковатых Б.С., Беликов Л.Н., Итинсон А.И., Щербаков А.Н., Князев В.В., Магомедалиева К.С. Лечение критической ишемии нижних конечностей у больных пожилого и старческого возраста с тяжелыми соматическими заболеваниями. Хирургия. Журнал имени Н.И. Пирогова. 2007; (8): 12-6.
  3. Resnick H.E., Lindsay R.S., McDermott M.M., Devereux R.B., Jones K.L., Fabsitz R.R. et al. Relationship of high and low ankle brachial index to all-cause and cardiovascular disease mortality. The Strong Heart Study. Circulation. 2004; 109(6): 733-9.
  4. Шулутко А.М., Семикова В.И. Облитерирующие заболевания артерий нижних конечностей. Методическое пособие для студентов старших курсов, интернов, ординаторов и практикующих врачей. М.: Первый московский государственный медицинский университет им. И.М. Сеченова; 2010.
  5. Kannel W.B., McGee D.L. Update on some epidemiologic features of intermittent claudication: the Framingham Study. J. Am. Geriatr. Soc. 1985; 33: 13-8.
  6. Norgren L., Hiatt W.R., Dormandy J.A., Nehler M.R., Harris K.A., Fowkes F.G. et al. Inter-society consensus for the management of peripheral arterial disease. Eur. J. Vasc. Endovasc. Surg. 2007; 33(Suppl. 1): 1-75.
  7. Fowkes F.G., Housley E., Cawood E.H., Macintyre C.C., Ruckley C.V., Prescott R.J. Edinburgh Artery Study: prevalence of asymptomatic and symptomatic peripheral arterial disease in the general population. Int. J. Epidemiol. 1991; 20(2): 384-92.
  8. United Nations Scientific Committee on the effects of Atomic Radiation (UNSCEAR). Effects of lonizing Radiation. UNSCEAR 2006 Report. Volume I. Report to the General Assembly Scientific Annexes A and B. New York: United Nations; 2008: 16.
  9. Azizova T.V., Haylock R.G., Moseeva M.B., Bannikova M.V., Grigoryeva E.S. Cerebrovascular diseases incidence and mortality in an extended Mayak worker cohort 1948-1982. Radiat. Res. 2014; 182(5): 529-44.
  10. Azizova T.V., Grigoryeva E.S., Haylock R.G., Pikulina M.V., Moseeva M.B. Ischeamic heart disease incidence and mortality in an extended cohort of Mayak workers first employed in 1948-1982. Br. J. Radiol. 2015; 88(1054): 20150169.
  11. Azizova T.V., Day R.D., Wald N., Muirhead C.R., O'Hagan J.A., Sumina M.V. et al. The «Clinic» medical-dosimetric database of Mayak production association workers: structure, characteristics and prospects of utilization. Health Phys. 2008; 94(5): 449-58.
  12. Koshurnikova N.A., Shilnikova N.S., Okatenko P.V., Kreslov V.V., Bolotnikova M.G., Sokolnikov M.E. et al. Characteristics of the cohort of workers at the Mayak nuclear complex. Radiat. Res. 1999; 152(4): 352-63.
  13. Vasilenko E.K., Scherpelz R.I., Gorelov M.V., Strom D.J., Smetanin M.Yu. External Dosimetry Reconstruction for Mayak Workers (2010) AAHP Special Session Health. Salt Lake City; 2010.
  14. Khokhryakov V.V., Khokhryakov V.F., Suslova K.G., Vostrotin V.V., Vvedensky V.E., Sokolova A.B. et al. Mayak Worker Dosimetry System 2008 (MWDS-2008): Assessment of internal dose from measurement results of plutonium activity in urine. Health Phys. 2013; 104(4): 366-78.
  15. Мерков А.М., Поляков Л.Е. Санитарная статистика (пособие для врачей). М.: Атомиздат; 1975.
  16. Диагностика и коррекция нарушений липидного обмена с целью профилактики и лечения атеросклероза (Российские рекомендации). Кардиоваскулярная терапия и профилактика. 2004; 6(Suppl. 3): 133-44.
  17. Criqui M.H. Peripheral arterial disease-epidemiological aspects. Vasc. Med. 2001; 6: 3-7.
  18. Fowler B., Jamrozik K., Norman P., Allen Y. Prevalence of peripheral arterial disease: persistence of excess risk in former smokers. Aust. N.Z. J. Public. Health. 2002; 26(3): 219-24.
  19. Оганов Р.Г., Шальнова С.А., Калинина А.М., Деев А.Д., Глазачев О.С., Гусев Е.И. и др. Новый способ оценки индивидуального сердечно-сосудистого суммарного риска для населения. Кардиология. 2008; (5): 87-91.
  20. Smith F.B., Lowe G.D., Lee A.J., Rumley A., Leng G.C., Fowkes F.G. Smoking, hemorheologic factors, and progression of peripheral arterial disease in patients with claudication. J. Vasc. Surg. 1998; 28: 129-35.
  21. Fowkes F.G., Housley E., Riemersma R.A., Macintyre C.C., Cawood E.H., Prescott R.J. et al. Smoking, lipids, glucose intolerance, and blood pressure as risk factors for peripheral atherosclerosis compared with ischemic heart disease in the Edinburgh Artery Study. Am. J. Epidemiol. 1992; 135: 331-40.

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