Email this article The algorithm of verification of risk of reactions of hypersensitivity to medicinal remedies in peri-operational period
- Authors: Jukova D.G.1, Fedenko E.S2, Yudin A.A1,3, Lebedeva N.V1, Nikitin A.E1, Loshkareva E.O4
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Affiliations:
- The central clinical hospital of the Russian academy of sciences
- The institute of immunology of the Federal medical biological agency of Russia
- The N.I. Pirogov Russian national research medical university Minzdrav of Russia
- N.I. Pirogov Russian national research medical university Minzdrav of Russia
- Issue: Vol 21, No 2 (2015)
- Pages: 16-22
- Section: Articles
- URL: https://journals.rcsi.science/0869-2106/article/view/38237
- DOI: https://doi.org/10.17816/rmj38237
- ID: 38237
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Abstract
The article presents the algorithm of identification of risk of reactions of hypersensitivity to medicinal remedies in perioperational period. The method includes clinical laboratory techniques and such allergenic tests as test of inhibition of natural emigration of leukocytes, sub lingual and dosage provocative test with evaluation of eosinophilia in peripheral blood and nasal secretion, increasing of basic level of tryptase (to detect hypersensitivity to anesthetics, antibiotics, nonsteroid anti-inflammatory remedies), application, prick- and intra-cutaneous tests (to detect hypersensitivity to anesthesia remedies, muscle relaxants, opioid analgesics, rentgenocontrast substances, vancomycin), prick-test with latex allergen. In 2010-2012, according to developed algorithm, in the central clinical hospital of the Russian academy of sciences 20 healthy volunteers were examined. The maximal concentrations of working solutions for cutaneous testing without irritation effect were selected. The absence of false positive results of tests and non-specific histamine liberation is demonstrated.
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##article.viewOnOriginalSite##About the authors
Dar'ya G. Jukova
The central clinical hospital of the Russian academy of sciences
Email: zulyaevan@mail.ru
doctor 117593 Moscow, Russia
E. S Fedenko
The institute of immunology of the Federal medical biological agency of Russia117593 Moscow, Russia
A. A Yudin
The central clinical hospital of the Russian academy of sciences; The N.I. Pirogov Russian national research medical university Minzdrav of Russia117593 Moscow, Russia
N. V Lebedeva
The central clinical hospital of the Russian academy of sciences117593 Moscow, Russia
A. E Nikitin
The central clinical hospital of the Russian academy of sciences117593 Moscow, Russia
E. O Loshkareva
N.I. Pirogov Russian national research medical university Minzdrav of Russia117997 Moscow, Russia
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