The markers of inflammation and their diagnostic and prognostic significance under infectious endocarditis


Cite item

Full Text

Abstract

The article presents the analysis of dynamics of markers of inflammation (C-reactive protein, tumor necrosis factor (α)) and procalcitonin in 66 patients with infectious endocarditis during six months of monitoring. The carried out study and clinical laboratory comparison made it possible to reveal consistent dynamics of indicators among patients with different course of disease at its various stages. The alterations of concentration of indicators are established in dynamics determining unfavorable prognosis under infectious endocarditis. The high sensitivity and informativeness of tumor necrosis factor (α) is established at all stages of course of disease.

About the authors

Tatyana Alekseevna Fedorova

The I.M. Sechenov first Moscow medical university

Кафедра терапии ФППОВ Moscow, Russia

Nanalija Aleksandrovna Semenenko

The I.M. Sechenov first Moscow medical university

Email: natascha1125@mail.ru
Кафедра терапии ФППОВ Moscow, Russia

Serafima Yakovlevna Tazina

The I.M. Sechenov first Moscow medical university

Кафедра терапии ФППОВ Moscow, Russia

Aleksandr Polyevich Roiytman

The Russian medical academy of post-graduate education

кафедра лабораторной диагностики Moscow, Russia

Tatjana Vladimirovna Kim

The I.M. Sechenov first Moscow medical university

Кафедра терапии ФППОВ Moscow, Russia

Natalia Igorevna Stefanenko

The I.M. Sechenov first Moscow medical university

Кафедра терапии ФППОВ Moscow, Russia

References

  1. Дробышева В. П. Инфекционный эндокардит: клиника, диагностика, лечение: Дис.. д-ра мед. наук. Новосибирск; 2003.
  2. Николаевский Е. Н. Клинико-морфологические варианты течения, диагностика и лечение инфекционного поражения эндокарда: Автореф. дис.. д-ра мед. наук. СПб.; 2004.
  3. Тюрин В. П. Инфекционные эндокардиты. М.: ГЭОТАР-Мед; 2012.
  4. Mueller С., Huber P., Laifer G., Mueller В., Perruchoud А. Р. Procalcitonin and the early diagnosis of infective endocarditis. Circulation. 2004; 109 (14): 1707—10.
  5. Watkin R. W., Harper L. V., Vernallis A. B., Lang S., Lambert P. A. et al. Proinflammatory cytokines IL6, TNFalpha, IL1beta, procalcitonin, lipopolysaccharide binding protein and C-reactive protein in infective endocarditis. J. Infect. 2007; 55 (3): 220—5.
  6. Wicher J., Bienvenu J., Monneret G. Procalcitonin as an acute phase marker. Ann. Clin. Biochem. 2001; 38: 483—93.
  7. Widmer E., Que Y. A., Entenza J. M., Moreillon P. New concepts in the pathophysiology of infective endocarditis. Curr. Infect. Dis. Rep. 2006; 8 (4); 271—9.

Copyright (c) 2013 Eco-Vector


 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies