Effect of serotonin adipinate on gastric vagal reactions


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Abstract

The interaction of serotonin-reactive structures that regulated gastric contractions with the parasympathetic part of the autonomic nervous system was studied. Acute experiments were carried out on 35 rabbits under surgical anesthesia, mechanical ventilation, bilateral vagotomy. Gastric mechanical and electrical activities were recorded. During the experiment, the peripheral segment of the vagus nerve was irritated in intact animals and on continuous exposure to serotonin adipinate. Serotonin was ascertained to enhance gastric vagal stimulatory reactions, by increasing both the magnitude of stimulatory reactions and their duration. It is concluded that there is a functional interaction of serotonin-reactive structures that regulate gastric motility with the parasympathetic part of the autonomic nervous system.

About the authors

V M Smirnov

Российский государственный медицинский университет, Москва

Кафедра нормальной физиологии; Российский государственный медицинский университет, Москва

Dmitriy Sergeevich Sveshnikov

Российский государственный медицинский университет, Москва

Email: dmsveshnikov@gmail.com
Кафедра нормальной физиологии, канд. мед. наук, доц. каф. нормальной физиологии РГМУ; Российский государственный медицинский университет, Москва

I L Myasnikov

Российский государственный медицинский университет, Москва

Кафедра нормальной физиологии; Российский государственный медицинский университет, Москва

A V Kuchuk

Российский государственный медицинский университет, Москва

Кафедра нормальной физиологии; Российский государственный медицинский университет, Москва

V M Smirnov

D S Sveshnikov

I L Myasnikov

A V Kuchuk

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