Genetic markers for insulin resistance in gestational diabetes mellitus


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Abstract

KCNJ, TCF7L2, PPARG2, ADIPOQ, ADIPOR, and ADIPOR2 gene polymorphisms and hormonal and metabolic markers (immunoreactive insulin, proinsulin, C-peptide, glycemia, lipid spectrum, leptin, glycated hemoglobin) were determined in 185 patients with gestational diabetes mellitus (GDM); of them 80 patients were diagnosed as having GDM during current pregnancy; GDM was diagnosed in 105 patients 4-19 years (14.6±3.8 years) ago.
Analysis of the distribution of the frequencies of alleles and genotypes of polymorphic markers in the study genes in healthy versus GDM pregnant women showed a significant increase in the frequency of Lys/Lys genotype of the polymorphic marker Glu23Lys in the KCNJ11 gene, a significant association of the pro and ala alleles of the polymorphic marker pro12ala in the PPARG2 gene and the A and T alleles and AA, AT, TT genotypes of the polymorphic marker A219T in the ADIPOR2 gene with GDM. The findings indicate the genetic features of GDM, which are associated with both abnormal sensitivity to insulin and its impaired secretion.

About the authors

Tat'yana Vasil'evna Sebko

Кафедра акушерства и гинекологии Московского факультета ГОУ ВПО РГМУ Росздрава

канд. мед. наук, доц. каф; Кафедра акушерства и гинекологии Московского факультета ГОУ ВПО РГМУ Росздрава

Yu E Dobrokhotova

Кафедра акушерства и гинекологии Московского факультета ГОУ ВПО РГМУ Росздрава

Кафедра акушерства и гинекологии Московского факультета ГОУ ВПО РГМУ Росздрава

T A Ivanova

Кафедра акушерства и гинекологии Московского факультета ГОУ ВПО РГМУ Росздрава

Кафедра акушерства и гинекологии Московского факультета ГОУ ВПО РГМУ Росздрава

V V Nosikov

Государственный научный центр генетики Российской Федерации

Государственный научный центр генетики Российской Федерации

T A Osipova

ООО "ЭФИС"

ООО "ЭФИС"

V S Potapov

Государственный научный центр генетики Российской Федерации

Государственный научный центр генетики Российской Федерации

T V Sebko

Yu E Dobrokhotova

T A Ivanova

V V Nosikov

T A Osipova

V S Potapov

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