Current perspective on the problem of autoimmune gastritis

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅存取

详细

Currently, there is an increase in the prevalence of autoimmune diseases. In particular, against the background of a decrease in the incidence of Helicobacter pylori associated gastritis, the number of patients with autoimmune gastritis increases. This is an autoimmune disease in which the destruction of the acid-producing gastric mucosa occurs due to the loss of parietal cells with their replacement by atrophic and metaplastic tissue, which leads to impaired absorption of iron, vitamin B12, deficiency states, anemia, neurological disorders and the development of malignant tumors. It is not fully known what triggers aggression. It is assumed that the autoimmune process can occur due to the interaction of genetic and environmental factors. In addition, the relationship between H. pylori and the development of autoimmune gastritis has not been fully studied.

Diagnosis of autoimmune gastritis is based on serological markers, but its leading method is esophagogastroduodenoscopy with biopsy. Several endoscopic signs allow one to suspect autoimmune gastritis: reverse atrophy; the presence of islets of preserved acid-producing mucosa; viscous mucus; protrusions in the body of the stomach, which are currently called "white spheres"; glomus formations, which are a proliferation of enterochromaffin-like cells. Atrophy of the mucous membrane of the body of the stomach is detected in biopsy material; three stages of inflammation of the mucous membrane of the body of the stomach can also be observed. Patients with autoimmune gastritis have an increased risk of developing malignant neoplasms, namely type 1 neuroendocrine tumors and adenocarcinoma. Therefore, regular monitoring is necessary for the early detection of these pathologies. However, the monitoring intervals have not been definitively determined. Most sources indicate the need for gastroscopy once every 1–3 years.

作者简介

Nikita Shcherbachenya

Pirogov City Clinical Hospital No. 1; DocMed Clinic of Evidence-Based Medicine

编辑信件的主要联系方式.
Email: endoscopy1995@mail.ru
ORCID iD: 0009-0001-7414-3819
俄罗斯联邦, Moscow; Moscow

Konstantin Vasilenko

Pirogov City Clinical Hospital No. 1

Email: kostikva1980@gmail.com
ORCID iD: 0000-0001-6669-7419

MD, Cand. Sci. (Medicine)

俄罗斯联邦, Moscow

参考

  1. Baker RE, Mahmud AS, Miller IF, et al. Infectious disease in an era of global change. Nat Rev Microbiol. 2022;20(4):193–205. doi: 10.1038/s41579-021-00639-z EDN: RPHUQI
  2. Vojdani A. A potential link between environmental triggers and autoimmunity. Autoimmune Dis. 2014;2014:437231. doi: 10.1155/2014/437231 EDN: PNQNAT
  3. Conrad N, Misra S, Verbakel JY, et al. Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK. Lancet. 2023;401(10391):1878–1890. doi: 10.1016/S0140-6736(23)00457-9 EDN: ZSASGO
  4. Castellana C, Eusebi LH, Dajti E, et al. Autoimmune atrophic gastritis: a clinical review. Cancers (Basel). 2024;16(7):1310. doi: 10.3390/cancers16071310 EDN: AQAHOJ
  5. Miceli E, Lenti MV, Padula D, et al. Common features of patients with autoimmune atrophic gastritis. Clin Gastroenterol Hepatol. 2012;10(7):812–814. doi: 10.1016/j.cgh.2012.02.018
  6. Li Y, Choi H, Leung K, et al. Global prevalence of Helicobacter pylori infection between 1980 and 2022: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2023;8(6):553–564. doi: 10.1016/S2468-1253(23)00070-5 EDN: TLYPOS
  7. Bordin D, Morozov S, Plavnik R, et al. Helicobacter pylori infection prevalence in ambulatory settings in 2017–2019 in Russia: The data of real-world national multicenter trial. Helicobacter. 2022;27(5):e12924. doi: 10.1111/hel.12924 EDN: KWJQSN
  8. Rustgi SD, Bijlani P, Shah SC. Autoimmune gastritis, with or without pernicious anemia: epidemiology, risk factors, and clinical management. Therap Adv Gastroenterol. 2021;14:17562848211038771. doi: 10.1177/17562848211038771 EDN: NHBIQL
  9. Kamada T, Maruyama Y, Monobe Y, Haruma K. Endoscopic features and clinical importance of autoimmune gastritis. Dig Endosc. 2022;34(4):700–713. doi: 10.1111/den.14175 EDN: NIPCPE
  10. Carmel R. Prevalence of undiagnosed pernicious anemia in the elderly. Arch Intern Med. 1996;156(10):1097–100. doi: 10.3748/wjg.15.5121
  11. Babior BM, Williams WJ. Erythrocyte disorders: anemias related to disturbance of DNA synthesis (megaloblastic anemias). Hematology. 1990;4:453–481.
  12. Kishino M, Nonaka K. Endoscopic features of autoimmune gastritis: focus on typical images and early images. J Clin Med. 2022;11(12):3523. doi: 10.3390/jcm11123523 EDN: APWFWO
  13. Park JY, Cornish TC, Lam-Himlin D, et al. Gastric lesions in patients with autoimmune metaplastic atrophic gastritis (AMAG) in a tertiary care setting. Am J Surg Pathol. 2010;34(11):1591–1598. doi: 10.1097/PAS.0b013e3181f623af
  14. Lahner E, Dilaghi E, Cingolani S, et al. Gender-sex differences in autoimmune atrophic gastritis. Transl Res. 2022;248:1–10. doi: 10.1016/j.trsl.2022.04.006 EDN: VKZAEK
  15. Miceli E, Vanoli A, Lenti MV, et al. Natural history of autoimmune atrophic gastritis: a prospective, single centre, long-term experience. Aliment Pharmacol Ther. 2019;50(11-12):1172–1180. doi: 10.1111/apt.15540
  16. Rugge M, Genta RM, Malfertheiner P, et al. RE.GA.IN.: the Real-world Gastritis Initiative-updating the updates. Gut. 2024;73(3):407–441. doi: 10.1136/gutjnl-2023-331164 EDN: RZCUAX
  17. Zhang H, Jin Z, Cui R, et al. Autoimmune metaplastic atrophic gastritis in chinese: a study of 320 patients at a large tertiary medical center. Scand J Gastroenterol. 2017;52(2):150–156. doi: 10.1080/00365521.2016.1236397
  18. Kalkan Ç, Soykan I. Polyautoimmunity in autoimmune gastritis. Eur J Intern Med. 2016;31:79–83. doi: 10.1016/j.ejim.2016.03.025
  19. Lenti MV, Miceli E, Cococcia S, et al. Determinants of diagnostic delay in autoimmune atrophic gastritis. Aliment Pharmacol Ther. 2019;50(2):167–175. doi: 10.1111/apt.15317
  20. Arango MT, Perricone C, Kivity S, et al. HLA-DRB1 the notorious gene in the mosaic of autoimmunity. Immunol Res. 2017;65(1):82–98. doi: 10.1007/s12026-016-8817-7 EDN: UAZHIU
  21. Lash R, Lauwers G, Odze R, et al. Inflammatory disorders of the stomach. In: Surgical pathology of the GI tract, liver, biliary tract, and pancreas. 2009. P. 293–295. doi: 10.1016/B978-141604059-0.50015-1 EDN: YWKBOD
  22. Kulnigg-Dabsch S. Autoimmune gastritis. Autoimmungastritis. Wien Med Wochenschr. 2016;166(13-14):424–430. doi: 10.1007/s10354-016-0515-5 EDN: SGXQPO
  23. Amedei A, Bergman MP, Appelmelk BJ, et al. Molecular mimicry between Helicobacter pylori antigens and H+, K+ — adenosine triphosphatase in human gastric autoimmunity. J Exp Med. 2003;198(8):1147–1156. doi: 10.1084/jem.20030530
  24. De Re V, Repetto O, De Zorzi M, et al. Polymorphism in toll-like receptors and Helicobacter Pylori Motility in autoimmune atrophic gastritis and gastric cancer. Cancers (Basel). 2019;11(5):648. doi: 10.3390/cancers11050648
  25. Ohana M, Okazaki K, Oshima C, et al. Inhibitory effects of Helicobacter pylori infection on murine autoimmune gastritis. Gut. 2003;52(8):1102–1110. doi: 10.1136/gut.52.8.1102
  26. Nishizawa T, Yoshida S, Watanabe H, et al. Clue of diagnosis for autoimmune gastritis. Digestion. 2021;102(6):903–910. doi: 10.1159/000516624 EDN: EWIDIW
  27. Terao S, Suzuki S, Yaita H, et al. Multicenter study of autoimmune gastritis in Japan: Clinical and endoscopic characteristics. Dig Endosc. 2020;32(3):364–372. doi: 10.1111/den.13500
  28. Chan JC, Liu HS, Kho BC, et al. Pattern of thyroid autoimmunity in chinese patients with pernicious anemia. Am J Med Sci. 2009;337(6):432–437. doi: 10.1097/MAJ.0b013e31819c0ecf
  29. De Block CE, De Leeuw IH, Van Gaal LF. Autoimmune gastritis in type 1 diabetes: a clinically oriented review. J Clin Endocrinol Metab. 2008;93(2):363–371. doi: 10.1210/jc.2007-2134
  30. Singh S, Chakole S, Agrawal S, et al. A comprehensive review of upper gastrointestinal symptom management in autoimmune gastritis: current insights and future directions. Cureus. 2023;15(8):e43418. doi: 10.7759/cureus.43418
  31. Carabotti M, Lahner E, Esposito G, et al. Upper gastrointestinal symptoms in autoimmune gastritis: A cross-sectional study. Medicine (Baltimore). 2017;96(1):e5784. doi: 10.1097/MD.0000000000005784
  32. Iwai W, Abe Y, Iijima K, et al. Gastric hypochlorhydria is associated with an exacerbation of dyspeptic symptoms in female patients. J Gastroenterol. 2013;48(2):214–221. doi: 10.1007/s00535-012-0634-8 EDN: JVKNBE
  33. Kalkan Ç, Soykan I, Soydal Ç, et al. Assessment of gastric emptying in patients with autoimmune gastritis. Dig Dis Sci. 2016;61(6):1597–1602. doi: 10.1007/s10620-015-4021-1 EDN: CGWBED
  34. Tenca A, Massironi S, Pugliese D, et al. Gastro-esophageal reflux and antisecretory drugs use among patients with chronic autoimmune atrophic gastritis: a study with pH-impedance monitoring. Neurogas-troenterol Motil. 2016;28(2):274–280. doi: 10.1111/nmo.12723
  35. Shipton MJ, Thachil J. Vitamin B12 deficiency — A 21st century perspective. Clin Med (Lond). 2015;15(2):145–150. doi: 10.7861/clinmedicine.15-2-145
  36. Conti L, Annibale B, Lahner E. Autoimmune gastritis and gastric microbiota. Microorganisms. 2020;8(11):1827. doi: 10.3390/microorganisms8111827 EDN: DLEEIZ
  37. Kriķe P, Appel MS, Shums Z, et al. Autoimmune gastritis serological biomarkers in gastric cancer patients. Eur J Cancer Prev. 2024;33(1):29–36. doi: 10.1097/CEJ.0000000000000826 EDN: YWLVHC
  38. Huang YK, Yu JC, Kang WM, et al. Significance of serum pepsinogens as a biomarker for gastric cancer and atrophic gastritis screening: a systematic review and meta-analysis. PLoS One. 2015;10(11):e0142080. doi: 10.1371/journal.pone.0142080 EDN: WTBGMJ
  39. Zagari RM, Rabitti S, Greenwood DC, et al. Systematic review with meta-analysis: diagnostic performance of the combination of pepsinogen, gastrin-17 and anti-Helicobacter pylori antibodies serum assays for the diagnosis of atrophic gastritis. Aliment Pharmacol Ther. 2017;46(7):657–667. doi: 10.1111/apt.14248 EDN: YFQBWK
  40. Kurokawa K, Maruyama M. Study of the gastric mucosal atrophic pattern and the complication of gastric cancer in pernicious anemia patiens and their family members. Gastroenterological Endoscopy. 1981;23(1):66–77. doi: 10.11280/gee1973b.23.66
  41. Krasinskas AM, Abraham SC, Metz DC, Furth EE. Oxyntic mucosa pseudopolyps: a presentation of atrophic autoimmune gastritis. Am J Surg Pathol. 2003;27(2):236–241. doi: 10.1097/00000478-200302000-00013
  42. Furuta T, Baba S, Yamade M, et al. High incidence of autoimmune gastritis in patients misdiagnosed with two or more failures of H. pylori eradication. Aliment Pharmacol Ther. 2018;48(3):370–377. doi: 10.1111/apt.14849
  43. Doyama H, Yoshida N, Tsuyama S, et al. The "white globe appearance" (WGA): a novel marker for a correct diagnosis of early gastric cancer by magnifying endoscopy with narrow-band imaging (M-NBI). Endosc Int Open. 2015;3(2):E120–E124. doi: 10.1055/s-0034-1391026
  44. Iwamuro M, Tanaka T, Kanzaki H, et al. Two cases of white globe appearance in autoimmune atrophic gastritis. Case Rep Gastrointest Med. 2018;2018:7091520. doi: 10.1155/2018/7091520
  45. Drapkina OM, Kashin SV, Kuvaev RO, et al. Modern algorithm of diagnostics and management of patients with chronic atrophic gastritis and intestinal metaplasia of the stomach. Russian Journal of Preventive Medicine and Public Health. 2023;26(1):7–10. doi: 10.17116/profmed2023260117 EDN: KURNXC
  46. Greenson JK, Lauwers GY, Montgomery EA, et al. Diagnostic pathology: gastrointestinal. 3rd ed. Amsterdam: Elsevier; 2019. P. 140v143. doi: 10.3390/gidisord1010011
  47. Itsuno M, Watanabe H, Iwafuchi M, et al. Multiple carcinoids and endocrine cell micronests in type A gastritis. Their morphology, histogenesis, and natural history. Cancer. 1989;63(5):881–890. doi: 10.1002/1097-0142(19890301)63:5<881::aid-cncr2820630515>3.0.co;2-k
  48. Maruyama Y, Yoshii S, Kageoka M. Features of magnifying endoscopic findings in type A gastritis. Stomach and Intestine. 2018;53:1516–1521.
  49. Arai J, Niikura R, Hayakawa Y, et al. Clinicopathological features of gastric cancer with autoimmune gastritis. Biomedicines. 2022;10(4):884. doi: 10.3390/biomedicines10040884
  50. Zhang H, Nie X, Song Z, et al. Hyperplastic polyps arising in autoimmune metaplastic atrophic gastritis patients: is this a distinct clinicopathological entity? Scand J Gastroenterol. 2018;53(10-11):1186–1193. doi: 10.1080/00365521.2018.1514420
  51. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol. 1996;20(10):1161–1181. doi: 10.1097/00000478-199610000-00001
  52. Pimentel-Nunes P, Libânio D, Marcos-Pinto R, et al. Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), Euro-pean Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019. Endoscopy. 2019;51(4):365–388. doi: 10.1055/a-0859-1883 EDN: KTPOEN
  53. Zhou Y, Li HY, Zhang JJ, et al. Operative link on gastritis assessment stage is an appropriate predictor of early gastric cancer. World J Gastroenterol. 2016;22(13):3670–3678. doi: 10.3748/wjg.v22.i13.3670
  54. Hall SN, Appelman HD. Autoimmune gastritis. Arch Pathol Lab Med. 2019;143(11):1327–1331. doi: 10.5858/arpa.2019-0345-RA
  55. Nehme F, Rowe K, Palko W, et al. Autoimmune metaplastic atrophic gastritis and association with neuroendocrine tumors of the stomach. Clin J Gastroenterol. 2020;13(3):299–307. doi: 10.1007/s12328-019-01074-7 EDN: AVNFRJ
  56. Dilaghi E, Dottori L, Pivetta G, et al. Incidence and predictors of gastric neoplastic lesions in corpus-restricted atrophic gastritis: a single-center cohort study. Am J Gastroenterol. 2023;118(12):2157–2165. doi: 10.14309/ajg.0000000000002327 EDN: KLTBGR
  57. Boyce M, Thomsen L. Gastric neuroendocrine tumors: prevalence in Europe, USA, and Japan, and rationale for treatment with a gastrin/CCK2 receptor antagonist. Scand J Gastroenterol. 2015;50(5):550–559. doi: 10.3109/00365521.2015.1009941
  58. Rugge M, Bricca L, Guzzinati S, et al. Autoimmune gastritis: long-term natural history in naïve Helicobacter pylori-negative patients. Gut. 2023;72(1):30–38. doi: 10.1136/gutjnl-2022-327827 EDN: EKWJPK
  59. Miceli E, Lenti MV, Gentile A, et al. Long-term natural history of autoimmune gastritis: results from a prospective monocentric series. Am J Gastroenterol. 2024;119(5):837–845. doi: 10.14309/ajg.0000000000002619 EDN: ADSLNP
  60. Shah SC, Piazuelo MB, Kuipers EJ, Li D. AGA clinical practice update on the diagnosis and management of atrophic gastritis: expert review. Gastroenterology. 2021;161(4):1325–1332.e7. doi: 10.1053/j.gastro.2021.06.078 EDN: JWYTUB
  61. Ivashkin VT, Maev IV, Lapina TL, et al. Clinical recommendations of Russian Gastroenterological Association and RENDO Endoscopic Society on diagnosis and treatment of gastritis and duodenitis. Rossijskij zhurnal gastrojenterologii, gepatologii, koloproktologii. 2021;31(4):70–99. doi: 10.22416/1382-4376-2021-31-4-70-99 EDN: CTXEBF

补充文件

附件文件
动作
1. JATS XML
2. Fig. 1. Diffuse atrophy of the gastric body mucosa when examined in inversion (a) and direct projection (b). © Eco-Vector, 2025.

下载 (196KB)
3. Fig. 2. Endoscopic view of “reverse” atrophy. Atrophic changes mucosa of the body of the stomach with preserved mucosa of the antral section. © Eco-Vector, 2025.

下载 (108KB)
4. Fig. 3. Endoscopic view of preserved acid-producing areas of the gastric body mucosa. © Eco-Vector, 2025.

下载 (155KB)
5. Fig. 4. Viscous secretion on the surface of mucosa in autoimmune gastritis. © Eco-Vector, 2025.

下载 (159KB)
6. Fig. 5. White globe appearance on the surface of mucosa in white light (a) and in narrow-band mode (b). © Eco-Vector, 2025.

下载 (163KB)
7. Fig. 6. Glomus-like lesions of the stomach (a), glomus-like lesions with white globe appearance and areas of foveolar hyperplasia (b). © Eco-Vector, 2025.

下载 (157KB)
8. Fig. 7. Picture of “cast-of skin appearance” — reticular capillary network without gland openings. © Eco-Vector, 2025.

下载 (109KB)
9. Fig. 8. “Circular wrinkled pattern” in the antral part of the stomach. © Eco-Vector, 2025.

下载 (68KB)
10. Fig. 9. Multiple hyperplastic polyps of the gastric body in autoimmune gastritis. © Eco-Vector, 2025.

下载 (81KB)
11. Fig. 10. Neuroendocrine tumors of the stomach in LCI (linked color imaging) mode (a, c) and in BLI (blue laser imaging) mode (b). © Eco-Vector, 2025.

下载 (165KB)

版权所有 © Eco-Vector, 2025

Creative Commons License
此作品已接受知识共享署名-非商业性使用-禁止演绎 4.0国际许可协议的许可。
 


Согласие на обработку персональных данных с помощью сервиса «Яндекс.Метрика»

1. Я (далее – «Пользователь» или «Субъект персональных данных»), осуществляя использование сайта https://journals.rcsi.science/ (далее – «Сайт»), подтверждая свою полную дееспособность даю согласие на обработку персональных данных с использованием средств автоматизации Оператору - федеральному государственному бюджетному учреждению «Российский центр научной информации» (РЦНИ), далее – «Оператор», расположенному по адресу: 119991, г. Москва, Ленинский просп., д.32А, со следующими условиями.

2. Категории обрабатываемых данных: файлы «cookies» (куки-файлы). Файлы «cookie» – это небольшой текстовый файл, который веб-сервер может хранить в браузере Пользователя. Данные файлы веб-сервер загружает на устройство Пользователя при посещении им Сайта. При каждом следующем посещении Пользователем Сайта «cookie» файлы отправляются на Сайт Оператора. Данные файлы позволяют Сайту распознавать устройство Пользователя. Содержимое такого файла может как относиться, так и не относиться к персональным данным, в зависимости от того, содержит ли такой файл персональные данные или содержит обезличенные технические данные.

3. Цель обработки персональных данных: анализ пользовательской активности с помощью сервиса «Яндекс.Метрика».

4. Категории субъектов персональных данных: все Пользователи Сайта, которые дали согласие на обработку файлов «cookie».

5. Способы обработки: сбор, запись, систематизация, накопление, хранение, уточнение (обновление, изменение), извлечение, использование, передача (доступ, предоставление), блокирование, удаление, уничтожение персональных данных.

6. Срок обработки и хранения: до получения от Субъекта персональных данных требования о прекращении обработки/отзыва согласия.

7. Способ отзыва: заявление об отзыве в письменном виде путём его направления на адрес электронной почты Оператора: info@rcsi.science или путем письменного обращения по юридическому адресу: 119991, г. Москва, Ленинский просп., д.32А

8. Субъект персональных данных вправе запретить своему оборудованию прием этих данных или ограничить прием этих данных. При отказе от получения таких данных или при ограничении приема данных некоторые функции Сайта могут работать некорректно. Субъект персональных данных обязуется сам настроить свое оборудование таким способом, чтобы оно обеспечивало адекватный его желаниям режим работы и уровень защиты данных файлов «cookie», Оператор не предоставляет технологических и правовых консультаций на темы подобного характера.

9. Порядок уничтожения персональных данных при достижении цели их обработки или при наступлении иных законных оснований определяется Оператором в соответствии с законодательством Российской Федерации.

10. Я согласен/согласна квалифицировать в качестве своей простой электронной подписи под настоящим Согласием и под Политикой обработки персональных данных выполнение мною следующего действия на сайте: https://journals.rcsi.science/ нажатие мною на интерфейсе с текстом: «Сайт использует сервис «Яндекс.Метрика» (который использует файлы «cookie») на элемент с текстом «Принять и продолжить».