Facial nerve neuropathy during the COVID-19 pandemic: clinical features, acupuncture treatment approaches
- Authors: Andreeva G.O.1, Odinak M.M.1, Litvinenko E.V.1, Lobzin V.Y.1,2, Shishkina E.V.3
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Affiliations:
- Military Medical Academy named after S.M. Kirov
- St Petersburg University
- City Consultative and Diagnostic Center No. 1, Saint Peterburg
- Issue: Vol 30, No 3 (2024)
- Pages: 218-227
- Section: Original Research Articles
- URL: https://journals.rcsi.science/0869-2106/article/view/262446
- DOI: https://doi.org/10.17816/medjrf629544
- ID: 262446
Cite item
Abstract
BACKGROUND: Facial nerve neuropathy (FNN) is a common mononeuropathy in the general stage of development of the peripheral nervous system. During the novel coronavirus disease (COVID-19) pandemic, the incidence of facial neuropathy increased from 1.3% in 2019 to 3.5% in 2020. Acute isolated neuropathy of the facial nerve may be the first and only manifestation of various infectious diseases, including COVID-19. Several experts showed that the mechanisms of facial neuropathy development after a coronavirus infection is associated with neuroinflammation.
Accepted therapeutic algorithms do not always lead to the expected results. Acupuncture potentially plays a key role in the treatment of this disease. In several cases, its superiority over drug treatment for FNN has been noted. No Russian studies on the treatment of post-COVID FNN were found.
AIM: This study aimed to study the clinical features of the course of FNN after COVID-19, develop reflexology approaches to treatment, and compare the course of FNN between patients with a history of coronavirus infection and those without a history of COVID-19 infection.
MATERIALS AND METHODS: The study group (after COVID-19) consisted of 16 patients with FNN (13 men, 3 women). The comparison group included 21 patients with FNN without a history of COVID-19 (15 men, 6 women). For a comprehensive patient assessment, clinical, neurological, and electroneuromyographic examination data were used.
RESULTS: The treatment results of 16 patients with FNN that developed up to 12 weeks after suffering from COVID-19 were analyzed. The onset of the disease was accompanied by an arterial hypertension episode, which was observed for the first time in two patients. Nerve fiber damage was mixed and severe (>52%). The dynamics of clinical and electrophysiological parameters in the study group (after COVID-19) were significantly slower compared to that of the group without a history of COVID.
CONCLUSION: FNN that develops after COVID-19 is characterized by severe nerve fibers damage and a long course. Reflexology is an effective and safe method as part of complex therapy.
Full Text
##article.viewOnOriginalSite##About the authors
Galina O. Andreeva
Military Medical Academy named after S.M. Kirov
Author for correspondence.
Email: galinandreev@yandex.ru
ORCID iD: 0000-0002-0350-3063
SPIN-code: 7128-6905
ResearcherId: I-4820-2016
MD, Dr. Sci. (Medicine)
Russian Federation, Saint PetersburgMiroslav M. Odinak
Military Medical Academy named after S.M. Kirov
Email: odinak@rambler.ru
ORCID iD: 0000-0002-7314-7711
SPIN-code: 1155-9732
Scopus Author ID: 7003327776
ResearcherId: I-6024-2016
MD, Dr. Sci. (Medicine), professor, corresponding member of the Russian Academy of Sciences
Russian Federation, Saint PetersburgElena V. Litvinenko
Military Medical Academy named after S.M. Kirov
Email: elenalitv@list.ru
ORCID iD: 0000-0002-2907-3129
SPIN-code: 5900-4225
MD, Cand. Sci. (Medicine)
Russian Federation, Saint PetersburgVladimir Y. Lobzin
Military Medical Academy named after S.M. Kirov; St Petersburg University
Email: vladimirlobzin@mail.ru
ORCID iD: 0000-0003-3109-8795
SPIN-code: 7779-3569
Scopus Author ID: 57203881632
ResearcherId: I-4819-2016
MD, Dr. Sci. (Medicine), professor
Russian Federation, Saint Peterburg; Saint PeterburgEl'vira V. Shishkina
City Consultative and Diagnostic Center No. 1, Saint Peterburg
Email: elllia@mail.ru
Russian Federation, Saint Peterburg
References
- Zammit M, Markey A, Webb C. A rise in facial nerve palsies during the coronavirus disease 2019 pandemic. J Laryngol Otol. doi: 10.1017/S0022215120002121
- Odinak MM, Litvinenko IV, editors. Nervous diseases: a textbook for medical students. Saint Petersburg: SpecLit; 2020. (In Russ).
- Finsterer J, Scorza FA, Scorza C, Fiorini A. COVID-19 associated cranial nerve neuropathy: asystematic review. Bosn J Basic Med Sci. 2022;22(1):39–45. doi: 10.17305/bjbms.2021.6341
- Islamoglu Y, Celik B, Kiris M. Facial paralys is as the only symptom of COVID-19: aprospectivestudy. Am J Otolaryngol. 2021;42(4):102956. doi: 10.1016/j.amjoto.2021.102956
- Wu Y, Xu X, Chen Z, et al. Nervous system involvement a fterinfection with COVID-19 and other corona viruses. Brain Behav Immun. 2020;87:18–22. doi: 10.1016/j.bbi.2020.03.031
- Belopasov VV, Yachou Y, Samoilova EM, Baklaushev VP. The nervous system damage in COVID-19. Journal of Clinical Practice. 2020;11(2):60–80. EDN: JLSSLO doi: 10.17816/clinpract34851
- Litvinenko IV, Lobzin VY, Pushkarev VA, Skripchenko NV. Infectious hypothesis of neurodegenerative diseases. What can await us after the COVID-19 pandemic? Russian Neurological Journal. 2022;27(3):64–73. EDN: AVNYIM doi: 10.30629/2658-7947-2022-27-3-64-73
- Vlasova TI, Spirina MA, Arsentieva EV, et al. Pathogenetic mechanisms of neurological post-COVID syndrome and the basis of its pathogenetic treatment and prevention (literature review). University Proceedings. Volga Region. Medical Sciences. 2021;(4):129–142. EDN: NSWGUJ doi: 10.21685/2072-3032-2021-4-11
- Zhang R, Wu T, Wang R, et al. Compare the efficacy of acupuncture with drugs in the treatment of Bell’s palsy: a systematic review and meta-analysis of RCTs. Medicine (Baltimore). 2019;98(19):e15566. doi: 10.1097/MD.0000000000015566
- House JW, Brackmann DE. Facial nerve grading system. Otolaryngol Head Neck Surg. 1985;93(2):146–147. doi: 10.1177/019459988509300202
- Junkerov VI, Grigoriev SG, Rezvantsev MV. Mathematical and statistical processing of medical research data. 3d edition. Saint Petersburg: VMedA; 2011. 318 p. (In Russ). EDN: XRYZWX
- https://www.nice.org.uk/ [Internet]. National Institute for Health and Care Excellence. COVID-19 rapid guideline: managing the long-term effects of COVID-19 [updated 2024 March 10]. Available from: https://www.nice.org.uk/guidance/ng188
- Singh D. Practical encyclopedia of oriental therapy. Acupuncture and moxotherapy. Moscow: AST; 1997. 464 p. (In Russ).
- Dubrovin D, Upur H. Theory and practice of classical Chinese medicine. Volume 1. Fundamentals of Chinese medicine. Saint Petersburg: Gumanitarnaja akademija; 2021. 596 p. (In Russ).
- Tykočinskaja ED. Basics of acupuncture. Moscow: Medicina; 1979. (In Russ).
- Hecker HU, Stivling A, Peke ET, Kastner J. Acupuncture: a practical guide / trans. from English. 2nd edition. Moscow: MEDpress-inform; 2021. (In Russ).
- Seon C, Lee DH, Kwon BI, et al. Neural mechanisms of acupuncture for peripheral facial nerve palsy: a protocol for systematic review and metaanalysis. Medicine (Baltimore). 2023;102(18):e33642. doi: 10.1097/MD.0000000000033642
- Andreeva GO. The new acupuncture technique in treatment of facial paralysis. Vestnik of Saint Petersburg University. Medicine. 2010;(4):36–41. EDN: NDLDIV
- Finsterer J, Scorza FA. Guillain-barre syndromein 220 patients with COVID-19. Egypt J Neurol Psychiatr Neurosurg. 2021;57(1):55. doi: 10.1186/s41983-021-00310-7
- Cabrera Muras A, Carmona-Abellán MM, Collía Fernández A, et al. Bilateral facial nerve palsy associated with COVID-19 and Epstein–Barr virus co-infection. Eur J Neurol. 2021;28(1):358–360. doi: 10.1111/ene.14561
- Helbok R, Beer R, Löscher W, et al. Guillain–Barre syndrome in a patient with antibodies against SARS-COV-2. Eur J Neurol. 2020;27(9):1754–1756. doi: 10.1111/ene.14388