Immunology of post-COVID syndrome
- Authors: Sсherbak S.G.1,2, Sarana A.M.2,3, Vologzhanin D.A.1,2, Kamilova T.A.1, Golota A.S.1, Makarenko S.V.1,2
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Affiliations:
- Saint-Petersburg City Hospital № 40 of Kurortny District
- St Petersburg University
- Health Committee of Saint Petersburg
- Issue: Vol 29, No 1 (2023)
- Pages: 43-58
- Section: Reviews
- URL: https://journals.rcsi.science/0869-2106/article/view/131861
- DOI: https://doi.org/10.17816/medjrf133829
- ID: 131861
Cite item
Abstract
COVID-19, the disease caused by SARS-CoV-2, has diverse long-term consequences of varying severity after recovery from the acute phase. As survivorship and therefore the number of individuals with “long COVID” continue to increase, the prevalence, origins, and mechanisms of post-acute sequelae manifestation must be critically elucidated. The inappropriate and unique inflammatory response in the acute phase of COVID-19 causes severe respiratory symptoms, which can be subsequently accompanied by multiple-organ damage, affecting the brain, heart, kidneys, etc. This review examines the role of an unregulated antigen-specific immune response to COVID-19 in the onset and development of its consequences. We discuss the potential role of virus persistence in tissue reservoirs, unresolved inflammation, cytokine hyperproduction, tissue damage, and molecular mimicry and autoimmunity in the pathogenesis of post-COVID syndrome — the induction and maintenance of imbalanced immune responses after the resolution of acute COVID-19.
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##article.viewOnOriginalSite##About the authors
Sergey G. Sсherbak
Saint-Petersburg City Hospital № 40 of Kurortny District; St Petersburg University
Email: b40@zdrav.spb.ru
ORCID iD: 0000-0001-5036-1259
SPIN-code: 1537-9822
MD, Dr. Sci. (Med.), professor
Russian Federation, Saint Petersburg; Saint PetersburgAndrey M. Sarana
St Petersburg University; Health Committee of Saint Petersburg
Email: asarana@mail.ru
ORCID iD: 0000-0003-3198-8990
SPIN-code: 7922-2751
MD, Cand. Sci. (Med.), associate professor
Russian Federation, Saint Petersburg; Saint PetersburgDmitry A. Vologzhanin
Saint-Petersburg City Hospital № 40 of Kurortny District; St Petersburg University
Email: volog@bk.ru
ORCID iD: 0000-0002-1176-794X
SPIN-code: 7922-7302
MD, Dr. Sci. (Med.)
Russian Federation, Saint Petersburg; Saint PetersburgTatyana A. Kamilova
Saint-Petersburg City Hospital № 40 of Kurortny District
Email: kamilovaspb@mail.ru
ORCID iD: 0000-0001-6360-132X
SPIN-code: 2922-4404
Cand. Sci. (Biol.)
Russian Federation, Saint PetersburgAleksandr S. Golota
Saint-Petersburg City Hospital № 40 of Kurortny District
Author for correspondence.
Email: golotaa@yahoo.com
ORCID iD: 0000-0002-5632-3963
SPIN-code: 7234-7870
MD, Cand. Sci. (Med.), associate professor
Russian Federation, 9B, Borisova street, 197706, Sestroretsk, Saint PetersburgStanislav V. Makarenko
Saint-Petersburg City Hospital № 40 of Kurortny District; St Petersburg University
Email: st.makarenko@gmail.com
ORCID iD: 0000-0002-1595-6668
SPIN-code: 8114-3984
Russian Federation, Saint Petersburg; Saint Petersburg
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